L'utilisation de biomarqueurs dans la SLA est-elle d'actualité ?

Translated title of the contribution: What are the applications of biomarkers in ALS today?

Hélène Blasco, Philippe Corcia, Pierre François Pradat

Research output: Contribution to journalShort surveypeer-review

1 Citation (Scopus)


Numerous biomarkers studies in ALS used targeted and non-targeted approaches, to help for the diagnosis, the prognosis or to identify new pathophysiological ways. The emerging approaches such as "omics" studies are very promising, but the practical and technical limits do not enable their optimization. Even if some biomarkers such as cystatin C or glutamate are highlighted in ALS, to date, no biomarker is currently used in routine practice. Diffusion-based neuroimaging has emerged as a tool to identify the involvement of the central neuron, but a recent meta-analysis shows a poor sensitivity and specificity. Spinal cord imaging has the advantage of simultaneoulsy investigating both the corticospinal tract and the peripheral motor neurons in the anterior horns of the spinal cord. Its interest to provide biomarkers in ALS is illustrated by recent studies that used a multiparametric approach.

Translated title of the contributionWhat are the applications of biomarkers in ALS today?
Original languageFrench
Pages (from-to)569-579
Number of pages11
JournalPresse Medicale
Issue number5
Publication statusPublished (in print/issue) - 1 Jan 2014


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