Abstract
| Language | English |
|---|---|
| Title of host publication | Unknown Host Publication |
| Pages | 341 |
| Number of pages | 1 |
| Volume | 48 |
| DOIs | |
| Publication status | E-pub ahead of print - 31 May 2016 |
| Event | American College of Sports Medicine (ACSM) Annual Meeting 2016 - Boston, Massachusetts Duration: 31 May 2016 → … |
Conference
| Conference | American College of Sports Medicine (ACSM) Annual Meeting 2016 |
|---|---|
| Period | 31/05/16 → … |
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Keywords
- Vitamin D
- Cathelicidin
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Lower Cathelicidin Concentrations In Irish Athletes Compared To Healthy Controls: A Role For Vitamin D? / Todd, Joshua J; McSorley, Emeir M; Pourshahidi, L. Kirsty; Madigan, Sharon M; Laird, Eamon L; Weir, Ruth R; Healy, Martin; Magee, Pamela J.
Unknown Host Publication. Vol. 48 2016. p. 341.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Lower Cathelicidin Concentrations In Irish Athletes Compared To Healthy Controls: A Role For Vitamin D?
AU - Todd, Joshua J
AU - McSorley, Emeir M
AU - Pourshahidi, L. Kirsty
AU - Madigan, Sharon M
AU - Laird, Eamon L
AU - Weir, Ruth R
AU - Healy, Martin
AU - Magee, Pamela J
PY - 2016/5/31
Y1 - 2016/5/31
N2 - The biologically active vitamin D metabolite (1[alpha]-dihydroxyvitamin D) has been linked to regulation of human cathelicidin antimicrobial peptide (LL-37) in vitro. Recent studies in athletes indicate that vitamin D inadequacy is associated with lower concentrations of LL-37 and that this may increase risk of upper respiratory tract infection (URTI). PURPOSE: To compare circulating LL-37 concentrations between athletes and healthy controls and to establish if total 25-hydroxyvitamin D (25[OH]D) was a significant determinant of this antimicrobial peptide.METHODS: A total of 221 stored, fasted plasma samples from male and female athletes (elite rugby n=12, elite boxing n=12, Gaelic football n=77) and age and sex-matched healthy controls (n=120) were analysed in duplicate for LL-37 concentrations using an enzyme-linked immunosorbent assay. Total 25(OH)D concentrations were quantified by liquid chromatography-tandem mass spectrometry as part of the previous studies. Comparison of 25(OH)D and LL-37 concentrations between athletes and controls was made using Mann-Whitney U tests. Linear regression was used to test if 25(OH)D concentration was a significant determinant of LL-37 concentration after adjusting for season of sampling.RESULTS: Median [IQR] 25(OH)D concentrations were 49.76[39.37] and 28.90[23.55] nmol/L for athletes and healthy controls respectively, P
AB - The biologically active vitamin D metabolite (1[alpha]-dihydroxyvitamin D) has been linked to regulation of human cathelicidin antimicrobial peptide (LL-37) in vitro. Recent studies in athletes indicate that vitamin D inadequacy is associated with lower concentrations of LL-37 and that this may increase risk of upper respiratory tract infection (URTI). PURPOSE: To compare circulating LL-37 concentrations between athletes and healthy controls and to establish if total 25-hydroxyvitamin D (25[OH]D) was a significant determinant of this antimicrobial peptide.METHODS: A total of 221 stored, fasted plasma samples from male and female athletes (elite rugby n=12, elite boxing n=12, Gaelic football n=77) and age and sex-matched healthy controls (n=120) were analysed in duplicate for LL-37 concentrations using an enzyme-linked immunosorbent assay. Total 25(OH)D concentrations were quantified by liquid chromatography-tandem mass spectrometry as part of the previous studies. Comparison of 25(OH)D and LL-37 concentrations between athletes and controls was made using Mann-Whitney U tests. Linear regression was used to test if 25(OH)D concentration was a significant determinant of LL-37 concentration after adjusting for season of sampling.RESULTS: Median [IQR] 25(OH)D concentrations were 49.76[39.37] and 28.90[23.55] nmol/L for athletes and healthy controls respectively, P
KW - Vitamin D
KW - Cathelicidin
U2 - 10.1249/01.mss.0000486035.92181.14
DO - 10.1249/01.mss.0000486035.92181.14
M3 - Conference contribution
VL - 48
SP - 341
BT - Unknown Host Publication
ER -