Lower Cathelicidin Concentrations In Irish Athletes Compared To Healthy Controls: A Role For Vitamin D?

Joshua J Todd, Emeir M McSorley, L. Kirsty Pourshahidi, Sharon M Madigan, Eamon L Laird, Ruth R Weir, Martin Healy, Pamela J Magee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The biologically active vitamin D metabolite (1[alpha]-dihydroxyvitamin D) has been linked to regulation of human cathelicidin antimicrobial peptide (LL-37) in vitro. Recent studies in athletes indicate that vitamin D inadequacy is associated with lower concentrations of LL-37 and that this may increase risk of upper respiratory tract infection (URTI). PURPOSE: To compare circulating LL-37 concentrations between athletes and healthy controls and to establish if total 25-hydroxyvitamin D (25[OH]D) was a significant determinant of this antimicrobial peptide.METHODS: A total of 221 stored, fasted plasma samples from male and female athletes (elite rugby n=12, elite boxing n=12, Gaelic football n=77) and age and sex-matched healthy controls (n=120) were analysed in duplicate for LL-37 concentrations using an enzyme-linked immunosorbent assay. Total 25(OH)D concentrations were quantified by liquid chromatography-tandem mass spectrometry as part of the previous studies. Comparison of 25(OH)D and LL-37 concentrations between athletes and controls was made using Mann-Whitney U tests. Linear regression was used to test if 25(OH)D concentration was a significant determinant of LL-37 concentration after adjusting for season of sampling.RESULTS: Median [IQR] 25(OH)D concentrations were 49.76[39.37] and 28.90[23.55] nmol/L for athletes and healthy controls respectively, P
Original languageEnglish
Title of host publicationUnknown Host Publication
PublisherWolters Kluwer
Pages341
Number of pages1
Volume48
DOIs
Publication statusE-pub ahead of print - 31 May 2016
EventAmerican College of Sports Medicine (ACSM) Annual Meeting 2016 - Boston, Massachusetts
Duration: 31 May 2016 → …

Conference

ConferenceAmerican College of Sports Medicine (ACSM) Annual Meeting 2016
Period31/05/16 → …

Keywords

  • Vitamin D
  • Cathelicidin

Fingerprint Dive into the research topics of 'Lower Cathelicidin Concentrations In Irish Athletes Compared To Healthy Controls: A Role For Vitamin D?'. Together they form a unique fingerprint.

Cite this