Low-Grade Systemic Inflammation is Associated with Domain-Specific Cognitive Performance and Cognitive Decline in Older Adults: Data from The TUDA Study

Adam H. Dyer; H McNulty; Aoife Caffrey; Shane Gordon; Eamon Laird; L. Hoey; Catherine Hughes; M Ward; JJ Strain; Maurice O'Kane; Fergal Tracey; Anne M. Molloy; Conal Cunningham; Kevin McCarroll

doi:10.1016/j.neurobiolaging.2023.11.008

Low-Grade Systemic Inflammation is Associated with Domain-Specific Cognitive Performance and Cognitive Decline in Older Adults: Data from The TUDA Study

Adam H. Dyer, H McNulty, Aoife Caffrey, Shane Gordon, Eamon Laird, L. Hoey, Catherine Hughes, M Ward, JJ Strain, Maurice O'Kane, Fergal Tracey, Anne M. Molloy, Conal Cunningham, Kevin McCarroll

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Abstract

Studies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS]). Higher IL-6 (OR: 1.33; 1.06, 1.66, p = 0.01),
TNF-α (OR: 1.35; 1.09, 1.67, p = 0.01) and IL-6:IL-10 Ratio (OR: 1.43; 1.17, 1.74, p = 0.001) were cross-sectionally associated with impaired global RBANS performance. For specific cognitive domains, greatest effect sizes were observed between higher TNF-α levels and poorer visual-spatial and attention performance. In a subset of participants (n = 725; 69.8 ± 5.5 years; 67.0% female) with repeat assessment performed at a median of 5.4 years, only higher baseline IL-6:IL-10 ratio was associated with impaired incident overall, immediate memory and visual-spatial performance. Associations were stronger in females, but not modified by age or APOE genotype.

Original language	English
Pages (from-to)	94-105
Number of pages	12
Journal	Neurobiology of Aging
Volume	134
Early online date	28 Nov 2023
DOIs	https://doi.org/10.1016/j.neurobiolaging.2023.11.008
Publication status	Published (in print/issue) - 2 Dec 2023

Bibliographical note

Funding Information:
The Trinity Ulster Department of Agriculture ( TUDA ) study was supported by government funding from the Irish Department of Agriculture, Food and the Marine and Health Research Board (under the Food Institutional Research Measure) and from the Northern Ireland Department for Employment and Learning (under its Strengthening the All-Island Research Base initiative). AHD is supported by the Meath Foundation at Tallaght University Hospital , the Wellcome-HRB Clinical Research Facility at St James's Hospital, Dublin, Ireland and has been awarded an Irish Clinical Academic Training (ICAT ) Fellowship the Irish Clinical Academic Training (ICAT) Programme, supported by the Wellcome Trust and the Health Research Board (Grant Number 203930/B/16/Z ), the Health Service Executive , National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland.

Publisher Copyright:
© 2023 Elsevier Inc.

Keywords

Inflammation
Inflammaging
Cognitive Impairment
Neuropsychological
Cytokine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neurobiolaging.2023.11.008

Cite this

Dyer, A. H., McNulty, H., Caffrey, A., Gordon, S., Laird, E., Hoey, L., Hughes, C., Ward, M., Strain, JJ., O'Kane, M., Tracey, F., Molloy, A. M., Cunningham, C., & McCarroll, K. (2023). Low-Grade Systemic Inflammation is Associated with Domain-Specific Cognitive Performance and Cognitive Decline in Older Adults: Data from The TUDA Study. Neurobiology of Aging, 134, 94-105. https://doi.org/10.1016/j.neurobiolaging.2023.11.008

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title = "Low-Grade Systemic Inflammation is Associated with Domain-Specific Cognitive Performance and Cognitive Decline in Older Adults: Data from The TUDA Study",

abstract = "Studies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS]). Higher IL-6 (OR: 1.33; 1.06, 1.66, p = 0.01),TNF-α (OR: 1.35; 1.09, 1.67, p = 0.01) and IL-6:IL-10 Ratio (OR: 1.43; 1.17, 1.74, p = 0.001) were cross-sectionally associated with impaired global RBANS performance. For specific cognitive domains, greatest effect sizes were observed between higher TNF-α levels and poorer visual-spatial and attention performance. In a subset of participants (n = 725; 69.8 ± 5.5 years; 67.0% female) with repeat assessment performed at a median of 5.4 years, only higher baseline IL-6:IL-10 ratio was associated with impaired incident overall, immediate memory and visual-spatial performance. Associations were stronger in females, but not modified by age or APOE genotype.",

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note = "Funding Information: The Trinity Ulster Department of Agriculture ( TUDA ) study was supported by government funding from the Irish Department of Agriculture, Food and the Marine and Health Research Board (under the Food Institutional Research Measure) and from the Northern Ireland Department for Employment and Learning (under its Strengthening the All-Island Research Base initiative). AHD is supported by the Meath Foundation at Tallaght University Hospital , the Wellcome-HRB Clinical Research Facility at St James's Hospital, Dublin, Ireland and has been awarded an Irish Clinical Academic Training (ICAT ) Fellowship the Irish Clinical Academic Training (ICAT) Programme, supported by the Wellcome Trust and the Health Research Board (Grant Number 203930/B/16/Z ), the Health Service Executive , National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

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Dyer, AH, McNulty, H , Caffrey, A, Gordon, S, Laird, E, Hoey, L , Hughes, C , Ward, M , Strain, JJ, O'Kane, M, Tracey, F, Molloy, AM, Cunningham, C & McCarroll, K 2023, 'Low-Grade Systemic Inflammation is Associated with Domain-Specific Cognitive Performance and Cognitive Decline in Older Adults: Data from The TUDA Study', Neurobiology of Aging, vol. 134, pp. 94-105. https://doi.org/10.1016/j.neurobiolaging.2023.11.008

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AU - Dyer, Adam H.

AU - McNulty, H

AU - Caffrey, Aoife

AU - Gordon, Shane

AU - Laird, Eamon

AU - Hoey, L.

AU - Hughes, Catherine

AU - Ward, M

AU - Strain, JJ

AU - O'Kane, Maurice

AU - Tracey, Fergal

AU - Molloy, Anne M.

AU - Cunningham, Conal

AU - McCarroll, Kevin

N1 - Funding Information: The Trinity Ulster Department of Agriculture ( TUDA ) study was supported by government funding from the Irish Department of Agriculture, Food and the Marine and Health Research Board (under the Food Institutional Research Measure) and from the Northern Ireland Department for Employment and Learning (under its Strengthening the All-Island Research Base initiative). AHD is supported by the Meath Foundation at Tallaght University Hospital , the Wellcome-HRB Clinical Research Facility at St James's Hospital, Dublin, Ireland and has been awarded an Irish Clinical Academic Training (ICAT ) Fellowship the Irish Clinical Academic Training (ICAT) Programme, supported by the Wellcome Trust and the Health Research Board (Grant Number 203930/B/16/Z ), the Health Service Executive , National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland. Publisher Copyright: © 2023 Elsevier Inc.

PY - 2023/12/2

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N2 - Studies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS]). Higher IL-6 (OR: 1.33; 1.06, 1.66, p = 0.01),TNF-α (OR: 1.35; 1.09, 1.67, p = 0.01) and IL-6:IL-10 Ratio (OR: 1.43; 1.17, 1.74, p = 0.001) were cross-sectionally associated with impaired global RBANS performance. For specific cognitive domains, greatest effect sizes were observed between higher TNF-α levels and poorer visual-spatial and attention performance. In a subset of participants (n = 725; 69.8 ± 5.5 years; 67.0% female) with repeat assessment performed at a median of 5.4 years, only higher baseline IL-6:IL-10 ratio was associated with impaired incident overall, immediate memory and visual-spatial performance. Associations were stronger in females, but not modified by age or APOE genotype.

AB - Studies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS]). Higher IL-6 (OR: 1.33; 1.06, 1.66, p = 0.01),TNF-α (OR: 1.35; 1.09, 1.67, p = 0.01) and IL-6:IL-10 Ratio (OR: 1.43; 1.17, 1.74, p = 0.001) were cross-sectionally associated with impaired global RBANS performance. For specific cognitive domains, greatest effect sizes were observed between higher TNF-α levels and poorer visual-spatial and attention performance. In a subset of participants (n = 725; 69.8 ± 5.5 years; 67.0% female) with repeat assessment performed at a median of 5.4 years, only higher baseline IL-6:IL-10 ratio was associated with impaired incident overall, immediate memory and visual-spatial performance. Associations were stronger in females, but not modified by age or APOE genotype.

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KW - Inflammaging

KW - Cognitive Impairment

KW - Neuropsychological

KW - Cytokine

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ER -

Low-Grade Systemic Inflammation is Associated with Domain-Specific Cognitive Performance and Cognitive Decline in Older Adults: Data from The TUDA Study

Abstract

Bibliographical note

Keywords

UN SDGs

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