Low frequency spectral analysis of ventricular fibrillation

E. J.F. Carlisle, W.George Kernohan, JD Allen, JMCC Anderson, A.A.J. Adgey

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Is the frequency of ventricular fibrillation (VF) in the human the same as in the dog, and does the dominant frequency of VF depend on the aetiology of this arrhythmia?  In 4 groups of 4 dogs the dominant frequency of the first 40 seconds of VF was measured using a Bruel and Kjaer spectrum analyzer {0-100 Hz).  For spontaneous VF following coronary artery occlusion (snare technique), the mean dominant frequency was 12.3 ±SEM 0.5 Hz. In reperfusion VF after coronary artery occlusion for 1 hour, the dominant frequency was 11.9±0.5 Hz.  The frequency of VF induced electrically after coronary artery occlusion for 1 hour was 11.4±0.4 Hz (no significant difference between the 3 groups). The frequency of glycoside-induced VF was 6.8±1.4 Hz which was significantly lower than that for the first 3 groups (p<0.02). In all 4 groups the frequency of VF fell significantly over 3 minutes (p<0.02).  The mean dominant frequency of the first 8 seconds of VF did not differ significantly in 13 patients with inferior infarction {6.5±0.2 Hz) from that in 7 patients with anterior infarction (6.5±0.3 Hz), nor did it vary significantly with time from the onset of symptoms of acute ischaemia to VF. In 1 patient, the frequency of VF fell from 6.0 Hz to 3.8 Hz after 90 seconds.  In 2 patients where VF followed directly periods of ventricular tachycardia, low frequencies of VF were recorded (3.75, 4.25 Hz).  The electro- physiological mechanisms of a dominant frequency in VF are not known.  Spectral analysis of VF in the dog does not differentiate myocardial ischaemia from reperfusion or electrically induced VF, but may in cardiac glycoside intoxication.  The higher dominant frequency of VF in the dog than in the human points to limitations of the use of this animal model in the study of VF.
Original languageEnglish
Title of host publicationX World Congress of cardiology
Place of PublicationWashington DC
Pages291
Number of pages1
Publication statusPublished - 14 Sep 1986
EventX World Congress of Cardiology - Washington, United States
Duration: 14 Sep 198619 Sep 1986

Conference

ConferenceX World Congress of Cardiology
Country/TerritoryUnited States
CityWashington
Period14/09/8619/09/86

Bibliographical note

Kernohan contributed signal analysis and advised on methods

Keywords

  • ventricular fibrillation

Fingerprint

Dive into the research topics of 'Low frequency spectral analysis of ventricular fibrillation'. Together they form a unique fingerprint.

Cite this