Low-dose vitamin B-6 lowers fasting plasma homocysteine levels in healthy elderly persons who are folate and riboflavin replete

MC McKinley, H McNulty, J McPartlin, JJ Strain, K Pentieva, M Ward, DG Weir, JM Scott

Research output: Contribution to journalArticle

Abstract

Background: Current data suggest that physiologic doses of vitamin B-6 have no significant homocysteine-lowering effect. It is possible that an effect of vitamin B-6 was missed in previous trials because of a much greater effect of folic acid, vitamin B-12, or both.Objective: The aim of this study was to investigate the effect of low-dose vitamin B-6 supplementation on fasting total homocysteine (tHcy) concentrations in healthy elderly persons who were made replete with folate and riboflavin.
LanguageEnglish
Pages759-764
JournalAmerican Journal of Clinical Nutrition
Volume73
Publication statusPublished - 2001

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Vitamin B 6
Riboflavin
Homocysteine
Folic Acid
Fasting
Vitamin B 12

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Cite this

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abstract = "Background: Current data suggest that physiologic doses of vitamin B-6 have no significant homocysteine-lowering effect. It is possible that an effect of vitamin B-6 was missed in previous trials because of a much greater effect of folic acid, vitamin B-12, or both.Objective: The aim of this study was to investigate the effect of low-dose vitamin B-6 supplementation on fasting total homocysteine (tHcy) concentrations in healthy elderly persons who were made replete with folate and riboflavin.",
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T1 - Low-dose vitamin B-6 lowers fasting plasma homocysteine levels in healthy elderly persons who are folate and riboflavin replete

AU - McKinley, MC

AU - McNulty, H

AU - McPartlin, J

AU - Strain, JJ

AU - Pentieva, K

AU - Ward, M

AU - Weir, DG

AU - Scott, JM

PY - 2001

Y1 - 2001

N2 - Background: Current data suggest that physiologic doses of vitamin B-6 have no significant homocysteine-lowering effect. It is possible that an effect of vitamin B-6 was missed in previous trials because of a much greater effect of folic acid, vitamin B-12, or both.Objective: The aim of this study was to investigate the effect of low-dose vitamin B-6 supplementation on fasting total homocysteine (tHcy) concentrations in healthy elderly persons who were made replete with folate and riboflavin.

AB - Background: Current data suggest that physiologic doses of vitamin B-6 have no significant homocysteine-lowering effect. It is possible that an effect of vitamin B-6 was missed in previous trials because of a much greater effect of folic acid, vitamin B-12, or both.Objective: The aim of this study was to investigate the effect of low-dose vitamin B-6 supplementation on fasting total homocysteine (tHcy) concentrations in healthy elderly persons who were made replete with folate and riboflavin.

KW - n/a

M3 - Article

VL - 73

SP - 759

EP - 764

JO - American Journal of Clinical Nutrition

T2 - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

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