Longitudinal study of spherical refractive error in infantilenystagmus syndrome

Natasha Healey, Julie McClelland, Kathryn Saunders, Jonathan Jackson

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Purpose: To explore the onset and progression of spherical refractive error in a population with infantile nystagmus syndrome.Methods: Retrospective refractive error data were obtained from 147 medical records of children with infantile nystagmus syndrome (albinism n=98; idiopathic infantile nystagmus n=49), attending a low vision clinic in Northern Ireland, over a 24 year period (1986-2010). Data were categorised by age to allow for comparisons with published studies. A prospective group of participants with INS (n=22 [albinism n=18, idiopathic infantile nystagmus n=4]) (aged 0-4 years) were also recruited. Cycloplegic streak retinoscopy was performed biannually, over a three year period. Spherical equivalent refractive error and most ametropic meridian were analysed.Results: The mean spherical equivalent refractive errors for albinism and idiopathic infantile nystagmus groups (across all age categories) were hypermetropic, with highest levels demonstrated by the participants with albinism aged 1≤4 years (Mann-Whitney U test, p=0.013). Mean most ametropic meridian was highest in the albinism group aged 1≤12 years (Mann-Whitney U test, p
Original languageEnglish
Pages (from-to)369-375
JournalOphthalmic and Physiological Optics
Issue number3
Publication statusPublished (in print/issue) - 22 Jan 2014


  • nystagmus
  • emmetropisation
  • vision
  • refractive error
  • children


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