Longitudinal retinal changes in children and young adults from the Northern Ireland Childhood Errors of Refraction (NICER) Study

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Aims: The purpose of this study is to investigate the longitudinal changes of cup-to-disc (CD) and arteriole-to-venule (A/V) ratios over time in children and to investigate the influence changes in refractive error and body composition may have on these parameters.
Materials and Methods: Images were captured at Phase 1 of the NICER study when participants were aged 6-7 and 12-13 years. The follow-up images were taken nine years later on the same children aged 15-16 and 21-22 years using the same image capture technique. In addition, image quality, cup depth and peripapillary atrophy were noted. The CD and A/V ratios were measured using ImageJ software using standardized retinal imaging measures. Measures of height and waist circumference were obtained and BMIs calculated. 
Results: No statistically significant differences were found for CD or A/V ratios between Phases 1 and 4 (all p>0.05) for either cohort. There was no statistically significant difference in change in CD or A/V ratios between refractive groups or between body composition categories for either cohort (ANOVA all p>0.05). Additionally, linear regression analysis showed no association between change in CD or A/V ratios with change in refractive error, axial length or BMI for both younger and older cohorts.
Conclusion: There was no statistically significant change in CD ratio over time for the younger or older cohort (average CD ratio of 0.28 across both cohorts at both time points). No statistically significant change occurred with A/V ratios over time for either cohort. The average A/V ratio for cohorts was approximately 0.79 (4:5 A/V) which is different to the typically described 2:3 relationship often reported. There was no significant correlation between changes in CD or A/V ratios with changing refractive error or changing axial length indicating that growth of retinal structures is at a similar rate to maintain constant ratios. Changes in BMI with time were not reflected in changes in A/V ratio in either cohort.
LanguageEnglish
Title of host publicationNorthern Ireland Clinical Research Network
Publication statusPublished - 15 Mar 2019

Fingerprint

Northern Ireland
Venules
Arterioles
Young Adult
Refractive Errors
Body Composition
Waist Circumference
Atrophy
Linear Models
Analysis of Variance
Software
Regression Analysis

Keywords

  • retina
  • optic disc
  • Retinal Vessels/pathology
  • refractive error
  • Children

Cite this

@inproceedings{203001b3bc804ee9b105de6548bdf6a2,
title = "Longitudinal retinal changes in children and young adults from the Northern Ireland Childhood Errors of Refraction (NICER) Study",
abstract = "Aims: The purpose of this study is to investigate the longitudinal changes of cup-to-disc (CD) and arteriole-to-venule (A/V) ratios over time in children and to investigate the influence changes in refractive error and body composition may have on these parameters.Materials and Methods: Images were captured at Phase 1 of the NICER study when participants were aged 6-7 and 12-13 years. The follow-up images were taken nine years later on the same children aged 15-16 and 21-22 years using the same image capture technique. In addition, image quality, cup depth and peripapillary atrophy were noted. The CD and A/V ratios were measured using ImageJ software using standardized retinal imaging measures. Measures of height and waist circumference were obtained and BMIs calculated. Results: No statistically significant differences were found for CD or A/V ratios between Phases 1 and 4 (all p>0.05) for either cohort. There was no statistically significant difference in change in CD or A/V ratios between refractive groups or between body composition categories for either cohort (ANOVA all p>0.05). Additionally, linear regression analysis showed no association between change in CD or A/V ratios with change in refractive error, axial length or BMI for both younger and older cohorts.Conclusion: There was no statistically significant change in CD ratio over time for the younger or older cohort (average CD ratio of 0.28 across both cohorts at both time points). No statistically significant change occurred with A/V ratios over time for either cohort. The average A/V ratio for cohorts was approximately 0.79 (4:5 A/V) which is different to the typically described 2:3 relationship often reported. There was no significant correlation between changes in CD or A/V ratios with changing refractive error or changing axial length indicating that growth of retinal structures is at a similar rate to maintain constant ratios. Changes in BMI with time were not reflected in changes in A/V ratio in either cohort.",
keywords = "retina, optic disc, Retinal Vessels/pathology, refractive error, Children",
author = "Tijana Radman and Julie McClelland and Saunders, {Kathryn J} and Lesley Doyle and Karen Breslin and Sara McCullough",
year = "2019",
month = "3",
day = "15",
language = "English",
booktitle = "Northern Ireland Clinical Research Network",

}

Longitudinal retinal changes in children and young adults from the Northern Ireland Childhood Errors of Refraction (NICER) Study. / Radman, Tijana; McClelland, Julie; Saunders, Kathryn J; Doyle, Lesley; Breslin, Karen; McCullough, Sara.

Northern Ireland Clinical Research Network . 2019.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Longitudinal retinal changes in children and young adults from the Northern Ireland Childhood Errors of Refraction (NICER) Study

AU - Radman, Tijana

AU - McClelland, Julie

AU - Saunders, Kathryn J

AU - Doyle, Lesley

AU - Breslin, Karen

AU - McCullough, Sara

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Aims: The purpose of this study is to investigate the longitudinal changes of cup-to-disc (CD) and arteriole-to-venule (A/V) ratios over time in children and to investigate the influence changes in refractive error and body composition may have on these parameters.Materials and Methods: Images were captured at Phase 1 of the NICER study when participants were aged 6-7 and 12-13 years. The follow-up images were taken nine years later on the same children aged 15-16 and 21-22 years using the same image capture technique. In addition, image quality, cup depth and peripapillary atrophy were noted. The CD and A/V ratios were measured using ImageJ software using standardized retinal imaging measures. Measures of height and waist circumference were obtained and BMIs calculated. Results: No statistically significant differences were found for CD or A/V ratios between Phases 1 and 4 (all p>0.05) for either cohort. There was no statistically significant difference in change in CD or A/V ratios between refractive groups or between body composition categories for either cohort (ANOVA all p>0.05). Additionally, linear regression analysis showed no association between change in CD or A/V ratios with change in refractive error, axial length or BMI for both younger and older cohorts.Conclusion: There was no statistically significant change in CD ratio over time for the younger or older cohort (average CD ratio of 0.28 across both cohorts at both time points). No statistically significant change occurred with A/V ratios over time for either cohort. The average A/V ratio for cohorts was approximately 0.79 (4:5 A/V) which is different to the typically described 2:3 relationship often reported. There was no significant correlation between changes in CD or A/V ratios with changing refractive error or changing axial length indicating that growth of retinal structures is at a similar rate to maintain constant ratios. Changes in BMI with time were not reflected in changes in A/V ratio in either cohort.

AB - Aims: The purpose of this study is to investigate the longitudinal changes of cup-to-disc (CD) and arteriole-to-venule (A/V) ratios over time in children and to investigate the influence changes in refractive error and body composition may have on these parameters.Materials and Methods: Images were captured at Phase 1 of the NICER study when participants were aged 6-7 and 12-13 years. The follow-up images were taken nine years later on the same children aged 15-16 and 21-22 years using the same image capture technique. In addition, image quality, cup depth and peripapillary atrophy were noted. The CD and A/V ratios were measured using ImageJ software using standardized retinal imaging measures. Measures of height and waist circumference were obtained and BMIs calculated. Results: No statistically significant differences were found for CD or A/V ratios between Phases 1 and 4 (all p>0.05) for either cohort. There was no statistically significant difference in change in CD or A/V ratios between refractive groups or between body composition categories for either cohort (ANOVA all p>0.05). Additionally, linear regression analysis showed no association between change in CD or A/V ratios with change in refractive error, axial length or BMI for both younger and older cohorts.Conclusion: There was no statistically significant change in CD ratio over time for the younger or older cohort (average CD ratio of 0.28 across both cohorts at both time points). No statistically significant change occurred with A/V ratios over time for either cohort. The average A/V ratio for cohorts was approximately 0.79 (4:5 A/V) which is different to the typically described 2:3 relationship often reported. There was no significant correlation between changes in CD or A/V ratios with changing refractive error or changing axial length indicating that growth of retinal structures is at a similar rate to maintain constant ratios. Changes in BMI with time were not reflected in changes in A/V ratio in either cohort.

KW - retina

KW - optic disc

KW - Retinal Vessels/pathology

KW - refractive error

KW - Children

M3 - Conference contribution

BT - Northern Ireland Clinical Research Network

ER -