Longitudinal point prevalence survey of antibacterial use in Northern Ireland using the European Surveillance of Antimicrobial Consumption (ESAC) PPS and Global-PPS tool

G.M. Al-Taani, M. Scott, D. Farren, F. Gilmore, B. McCullagh, C. Hibberd, A. McCorry, A. Versporten, H. Goossens, P. Zarb, M.A. Aldeyab

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Antimicrobial resistance is a limiting factor for the success of the treatment of infectious diseases and is associated with increased morbidity and cost. The present study aims to evaluate prescribing patterns of antimicrobials and quantify progress in relation to targets for quality improvement in the prescription of antimicrobials in Northern Ireland's secondary care sector using three repetitive point prevalence surveys (PPS) over a 6-year period: The European Surveillance of Antimicrobial Consumption (ESAC-PPS) in 2009 and 2011 and the Global-PPS on Antimicrobial Consumption and Resistance in 2015. Out of 3605 patients surveyed over the three time points, 1239 (34.4%) were treated with an antibiotic, the most frequently prescribed antibiotic groups were a combination of penicillins, including β-lactamase inhibitors. Compliance with hospital antibiotic policies in 2009, 2011 and 2015 were 54.5%, 71.5% and 79.9%, respectively. Likewise, an indication for treatment was recorded in patient notes 88.5%, 87.7% and 90.6% in 2009, 2011 and 2015, respectively, and surgical prophylactic antibiotic prescriptions for >24 h was 3.9%, 3.2% and 0.7% in 2009, 2011 and 2015, respectively. Treatment based on biomarker data was used in 61.5% of cases. In conclusion, a general trend in the improvement of key antimicrobial-related quality indicators was noted. The PPS tool provided a convenient, inexpensive surveillance system of antimicrobial consumption and should be considered an essential component to establish and maintain informed antibiotic stewardship in hospitals. © 2018 Cambridge University Press.
LanguageEnglish
Pages985-990
Number of pages6
JournalEpidemiology and Infection
Volume146
Issue number8
Early online date25 Apr 2018
DOIs
Publication statusPublished - Jun 2018

Fingerprint

Northern Ireland
Anti-Bacterial Agents
Prescriptions
Secondary Care
Quality Improvement
Penicillins
Communicable Diseases
Therapeutics
Biomarkers
Surveys and Questionnaires
Morbidity
Costs and Cost Analysis

Keywords

  • antimicrobial consumption
  • benchmarking
  • ESAC PPS
  • Global PPS
  • pharmacoepidemiology

Cite this

Al-Taani, G.M. ; Scott, M. ; Farren, D. ; Gilmore, F. ; McCullagh, B. ; Hibberd, C. ; McCorry, A. ; Versporten, A. ; Goossens, H. ; Zarb, P. ; Aldeyab, M.A. / Longitudinal point prevalence survey of antibacterial use in Northern Ireland using the European Surveillance of Antimicrobial Consumption (ESAC) PPS and Global-PPS tool. In: Epidemiology and Infection. 2018 ; Vol. 146, No. 8. pp. 985-990.
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title = "Longitudinal point prevalence survey of antibacterial use in Northern Ireland using the European Surveillance of Antimicrobial Consumption (ESAC) PPS and Global-PPS tool",
abstract = "Antimicrobial resistance is a limiting factor for the success of the treatment of infectious diseases and is associated with increased morbidity and cost. The present study aims to evaluate prescribing patterns of antimicrobials and quantify progress in relation to targets for quality improvement in the prescription of antimicrobials in Northern Ireland's secondary care sector using three repetitive point prevalence surveys (PPS) over a 6-year period: The European Surveillance of Antimicrobial Consumption (ESAC-PPS) in 2009 and 2011 and the Global-PPS on Antimicrobial Consumption and Resistance in 2015. Out of 3605 patients surveyed over the three time points, 1239 (34.4{\%}) were treated with an antibiotic, the most frequently prescribed antibiotic groups were a combination of penicillins, including β-lactamase inhibitors. Compliance with hospital antibiotic policies in 2009, 2011 and 2015 were 54.5{\%}, 71.5{\%} and 79.9{\%}, respectively. Likewise, an indication for treatment was recorded in patient notes 88.5{\%}, 87.7{\%} and 90.6{\%} in 2009, 2011 and 2015, respectively, and surgical prophylactic antibiotic prescriptions for >24 h was 3.9{\%}, 3.2{\%} and 0.7{\%} in 2009, 2011 and 2015, respectively. Treatment based on biomarker data was used in 61.5{\%} of cases. In conclusion, a general trend in the improvement of key antimicrobial-related quality indicators was noted. The PPS tool provided a convenient, inexpensive surveillance system of antimicrobial consumption and should be considered an essential component to establish and maintain informed antibiotic stewardship in hospitals. {\circledC} 2018 Cambridge University Press.",
keywords = "antimicrobial consumption, benchmarking, ESAC PPS, Global PPS, pharmacoepidemiology",
author = "G.M. Al-Taani and M. Scott and D. Farren and F. Gilmore and B. McCullagh and C. Hibberd and A. McCorry and A. Versporten and H. Goossens and P. Zarb and M.A. Aldeyab",
note = "Export Date: 15 September 2018 CODEN: EPINE Correspondence Address: Aldeyab, M.A.; School of Pharmacy and Pharmaceutical Sciences, Ulster UniversityUnited Kingdom; email: m.aldeyab@ulster.ac.uk References: Amadeo, B., European Surveillance of Antibiotic Consumption (ESAC) point prevalence survey 2008: Paediatric antimicrobial prescribing in 32 hospitals of 21 European countries (2010) Journal of Antimicrobial Chemotherapy, 65, pp. 2247-2252; Robert, J., Point prevalence survey of antibiotic use in French hospitals in 2009 (2012) Journal of Antimicrobial Chemotherapy, 67, pp. 1020-1026; Lipsitch, M., Bergstrom, C., Levin, B., The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions (2000) Proceedings of the National Academy of Sciences of the United States of America, 97, pp. 1938-1943; Heritage, J., Reducing inappropriate antibiotics prescribing: The role of online commentary on physical examination findings (2010) Patient Education and Counseling, 81, pp. 119-125; Goossens, H., Outpatient antibiotic use in Europe and association with resistance: A cross-national database study (2005) The Lancet, 365, pp. 579-587; Costelloe, C., Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: Systematic review and meta-analysis (2010) British Medical Journal, 340, p. c2096; Struelens, M., The epidemiology of antimicrobial resistance in hospital acquired infections: Problems and possible solutions (1998) British Medical Journal, 317, pp. 652-654; Ansari, F., The European Surveillance of Antimicrobial Consumption (ESAC) point-prevalence survey of antibacterial use in 20 European hospitals in 2006 (2009) Clinical Infectious Diseases, 49, pp. 1496-1504; Zarb, P., Identification of targets for quality improvement in antimicrobial prescribing: The web-based ESAC Point Prevalence Survey 2009 (2011) Journal of Antimicrobial Chemotherapy, 66, pp. 443-449; Willemsen, I., Appropriateness of antimicrobial therapy measured by repeated prevalence surveys (2007) Antimicrobial Agents and Chemotherapy, 51, pp. 864-867; Retamar, P., Evaluating the quality of antimicrobial prescribing: Is standardisation possible? Enfermedades Infecciosas y Microbiologi{\'a} (2013) Cl{\'i}nica, 31, pp. 25-30; Skoog, G., Repeated nationwide point-prevalence surveys of antimicrobial use in Swedish hospitals: Data for actions 2003-2010 (2016) Eurosurveillance, 21, pp. 13-21; Usluer, G., Ozgunes, I., Leblebicioglu, H., A multicenter pointprevalence study: Antimicrobial prescription frequencies in hospitalized patients in Turkey (2005) Annals of Clinical Microbiology and Antimicrobials, 4, p. 16; Versporten, A., The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: Developing hospital-quality indicators of antibiotic prescribing for children (2016) Journal of Antimicrobial Chemotherapy, 71, pp. 1106-1117; Štefkoviov{\'a}, M.E., Point prevalence study of antimicrobial usage in acute care hospitals in the Slovak Republic (2016) Journal of Hospital Infection, 93, pp. 403-409; Bantar, C., A hospital wide intervention program to optimize the quality of antibiotic use: Impact on prescribing practice, antibiotic consumption, cost savings, bacterial resistance (2003) Clinical Infectious Diseases, 37, pp. 180-186; Wise, E., Antimicrobial resistance: Is a major threat to public health (1998) British Medical Journal, 317, p. 609; Aldeyab, M.A., A point prevalence survey of antibiotic prescriptions: Benchmarking and patterns of use (2011) British Journal of Clinical Pharmacology, 71, pp. 293-296; Hohmann, C., Adherence to guidelines for antibiotic prophylaxis in surgery patients in German hospitals: A multicentre evaluation involving pharmacy interns (2012) Infection, 40, pp. 131-137; Tourmousoglou, C.E., Adherence to guidelines for antibiotic prophylaxis in general surgery: A critical appraisal (2008) Journal of Antimicrobial Chemotherapy, 61, pp. 214-218; Bratzler, D.W., Houck, P.M., Antimicrobial prophylaxis for surgery: An advisory statement from the National Surgical Infection Prevention Project (2005) American Journal of Surgery, 189, pp. 395-404. , Workgroup SIPGW; Aldeyab, M.A., Impact of an enhanced antibiotic stewardship on reducing methicillin-resistant Staphylococcus aureus in primary and secondary healthcare settings (2013) Epidemiology and Infection, 5, pp. 1-7; Aldeyab, M.A., A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool (2012) Epidemiology and Infection, 140, pp. 1714-1720",
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Al-Taani, GM, Scott, M, Farren, D, Gilmore, F, McCullagh, B, Hibberd, C, McCorry, A, Versporten, A, Goossens, H, Zarb, P & Aldeyab, MA 2018, 'Longitudinal point prevalence survey of antibacterial use in Northern Ireland using the European Surveillance of Antimicrobial Consumption (ESAC) PPS and Global-PPS tool', Epidemiology and Infection, vol. 146, no. 8, pp. 985-990. https://doi.org/10.1017/S095026881800095X

Longitudinal point prevalence survey of antibacterial use in Northern Ireland using the European Surveillance of Antimicrobial Consumption (ESAC) PPS and Global-PPS tool. / Al-Taani, G.M.; Scott, M.; Farren, D.; Gilmore, F.; McCullagh, B.; Hibberd, C.; McCorry, A.; Versporten, A.; Goossens, H.; Zarb, P.; Aldeyab, M.A.

In: Epidemiology and Infection, Vol. 146, No. 8, 06.2018, p. 985-990.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Longitudinal point prevalence survey of antibacterial use in Northern Ireland using the European Surveillance of Antimicrobial Consumption (ESAC) PPS and Global-PPS tool

AU - Al-Taani, G.M.

AU - Scott, M.

AU - Farren, D.

AU - Gilmore, F.

AU - McCullagh, B.

AU - Hibberd, C.

AU - McCorry, A.

AU - Versporten, A.

AU - Goossens, H.

AU - Zarb, P.

AU - Aldeyab, M.A.

N1 - Export Date: 15 September 2018 CODEN: EPINE Correspondence Address: Aldeyab, M.A.; School of Pharmacy and Pharmaceutical Sciences, Ulster UniversityUnited Kingdom; email: m.aldeyab@ulster.ac.uk References: Amadeo, B., European Surveillance of Antibiotic Consumption (ESAC) point prevalence survey 2008: Paediatric antimicrobial prescribing in 32 hospitals of 21 European countries (2010) Journal of Antimicrobial Chemotherapy, 65, pp. 2247-2252; Robert, J., Point prevalence survey of antibiotic use in French hospitals in 2009 (2012) Journal of Antimicrobial Chemotherapy, 67, pp. 1020-1026; Lipsitch, M., Bergstrom, C., Levin, B., The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions (2000) Proceedings of the National Academy of Sciences of the United States of America, 97, pp. 1938-1943; Heritage, J., Reducing inappropriate antibiotics prescribing: The role of online commentary on physical examination findings (2010) Patient Education and Counseling, 81, pp. 119-125; Goossens, H., Outpatient antibiotic use in Europe and association with resistance: A cross-national database study (2005) The Lancet, 365, pp. 579-587; Costelloe, C., Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: Systematic review and meta-analysis (2010) British Medical Journal, 340, p. c2096; Struelens, M., The epidemiology of antimicrobial resistance in hospital acquired infections: Problems and possible solutions (1998) British Medical Journal, 317, pp. 652-654; Ansari, F., The European Surveillance of Antimicrobial Consumption (ESAC) point-prevalence survey of antibacterial use in 20 European hospitals in 2006 (2009) Clinical Infectious Diseases, 49, pp. 1496-1504; Zarb, P., Identification of targets for quality improvement in antimicrobial prescribing: The web-based ESAC Point Prevalence Survey 2009 (2011) Journal of Antimicrobial Chemotherapy, 66, pp. 443-449; Willemsen, I., Appropriateness of antimicrobial therapy measured by repeated prevalence surveys (2007) Antimicrobial Agents and Chemotherapy, 51, pp. 864-867; Retamar, P., Evaluating the quality of antimicrobial prescribing: Is standardisation possible? Enfermedades Infecciosas y Microbiologiá (2013) Clínica, 31, pp. 25-30; Skoog, G., Repeated nationwide point-prevalence surveys of antimicrobial use in Swedish hospitals: Data for actions 2003-2010 (2016) Eurosurveillance, 21, pp. 13-21; Usluer, G., Ozgunes, I., Leblebicioglu, H., A multicenter pointprevalence study: Antimicrobial prescription frequencies in hospitalized patients in Turkey (2005) Annals of Clinical Microbiology and Antimicrobials, 4, p. 16; Versporten, A., The Worldwide Antibiotic Resistance and Prescribing in European Children (ARPEC) point prevalence survey: Developing hospital-quality indicators of antibiotic prescribing for children (2016) Journal of Antimicrobial Chemotherapy, 71, pp. 1106-1117; Štefkoviová, M.E., Point prevalence study of antimicrobial usage in acute care hospitals in the Slovak Republic (2016) Journal of Hospital Infection, 93, pp. 403-409; Bantar, C., A hospital wide intervention program to optimize the quality of antibiotic use: Impact on prescribing practice, antibiotic consumption, cost savings, bacterial resistance (2003) Clinical Infectious Diseases, 37, pp. 180-186; Wise, E., Antimicrobial resistance: Is a major threat to public health (1998) British Medical Journal, 317, p. 609; Aldeyab, M.A., A point prevalence survey of antibiotic prescriptions: Benchmarking and patterns of use (2011) British Journal of Clinical Pharmacology, 71, pp. 293-296; Hohmann, C., Adherence to guidelines for antibiotic prophylaxis in surgery patients in German hospitals: A multicentre evaluation involving pharmacy interns (2012) Infection, 40, pp. 131-137; Tourmousoglou, C.E., Adherence to guidelines for antibiotic prophylaxis in general surgery: A critical appraisal (2008) Journal of Antimicrobial Chemotherapy, 61, pp. 214-218; Bratzler, D.W., Houck, P.M., Antimicrobial prophylaxis for surgery: An advisory statement from the National Surgical Infection Prevention Project (2005) American Journal of Surgery, 189, pp. 395-404. , Workgroup SIPGW; Aldeyab, M.A., Impact of an enhanced antibiotic stewardship on reducing methicillin-resistant Staphylococcus aureus in primary and secondary healthcare settings (2013) Epidemiology and Infection, 5, pp. 1-7; Aldeyab, M.A., A point prevalence survey of antibiotic use in four acute-care teaching hospitals utilizing the European Surveillance of Antimicrobial Consumption (ESAC) audit tool (2012) Epidemiology and Infection, 140, pp. 1714-1720

PY - 2018/6

Y1 - 2018/6

N2 - Antimicrobial resistance is a limiting factor for the success of the treatment of infectious diseases and is associated with increased morbidity and cost. The present study aims to evaluate prescribing patterns of antimicrobials and quantify progress in relation to targets for quality improvement in the prescription of antimicrobials in Northern Ireland's secondary care sector using three repetitive point prevalence surveys (PPS) over a 6-year period: The European Surveillance of Antimicrobial Consumption (ESAC-PPS) in 2009 and 2011 and the Global-PPS on Antimicrobial Consumption and Resistance in 2015. Out of 3605 patients surveyed over the three time points, 1239 (34.4%) were treated with an antibiotic, the most frequently prescribed antibiotic groups were a combination of penicillins, including β-lactamase inhibitors. Compliance with hospital antibiotic policies in 2009, 2011 and 2015 were 54.5%, 71.5% and 79.9%, respectively. Likewise, an indication for treatment was recorded in patient notes 88.5%, 87.7% and 90.6% in 2009, 2011 and 2015, respectively, and surgical prophylactic antibiotic prescriptions for >24 h was 3.9%, 3.2% and 0.7% in 2009, 2011 and 2015, respectively. Treatment based on biomarker data was used in 61.5% of cases. In conclusion, a general trend in the improvement of key antimicrobial-related quality indicators was noted. The PPS tool provided a convenient, inexpensive surveillance system of antimicrobial consumption and should be considered an essential component to establish and maintain informed antibiotic stewardship in hospitals. © 2018 Cambridge University Press.

AB - Antimicrobial resistance is a limiting factor for the success of the treatment of infectious diseases and is associated with increased morbidity and cost. The present study aims to evaluate prescribing patterns of antimicrobials and quantify progress in relation to targets for quality improvement in the prescription of antimicrobials in Northern Ireland's secondary care sector using three repetitive point prevalence surveys (PPS) over a 6-year period: The European Surveillance of Antimicrobial Consumption (ESAC-PPS) in 2009 and 2011 and the Global-PPS on Antimicrobial Consumption and Resistance in 2015. Out of 3605 patients surveyed over the three time points, 1239 (34.4%) were treated with an antibiotic, the most frequently prescribed antibiotic groups were a combination of penicillins, including β-lactamase inhibitors. Compliance with hospital antibiotic policies in 2009, 2011 and 2015 were 54.5%, 71.5% and 79.9%, respectively. Likewise, an indication for treatment was recorded in patient notes 88.5%, 87.7% and 90.6% in 2009, 2011 and 2015, respectively, and surgical prophylactic antibiotic prescriptions for >24 h was 3.9%, 3.2% and 0.7% in 2009, 2011 and 2015, respectively. Treatment based on biomarker data was used in 61.5% of cases. In conclusion, a general trend in the improvement of key antimicrobial-related quality indicators was noted. The PPS tool provided a convenient, inexpensive surveillance system of antimicrobial consumption and should be considered an essential component to establish and maintain informed antibiotic stewardship in hospitals. © 2018 Cambridge University Press.

KW - antimicrobial consumption

KW - benchmarking

KW - ESAC PPS

KW - Global PPS

KW - pharmacoepidemiology

U2 - 10.1017/S095026881800095X

DO - 10.1017/S095026881800095X

M3 - Article

VL - 146

SP - 985

EP - 990

JO - Epidemiology and Infection

T2 - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 8

ER -