Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease

James Eaden; Paul Hughes; Guilhem Collier; Graham Norquay; Nicholas Weatherly; Matthew Austin; Laurie Smith; Jim Lithgow; Andrew Swift; Stephen Renshaw; Maya Buch; Colm Leonard; Sarah Skeoch; Nazia Chaudhuri; Geoff Parker; Stephen Bianchi; Jim Wild

doi:10.1183/13993003.congress-2019.PA3158

Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease

James Eaden
, Paul Hughes
, Guilhem Collier
, Graham Norquay
, Nicholas Weatherly
, Matthew Austin
, Laurie Smith
, Jim Lithgow
, Andrew Swift
, Stephen Renshaw
, Maya Buch
, Colm Leonard
, Sarah Skeoch
, Nazia Chaudhuri
, Geoff Parker
, Stephen Bianchi
, Jim Wild

Research output: Contribution to journal › Conference article › peer-review

Abstract

Introduction: Hyperpolarised 129-xenon (129Xe) MR spectroscopy (MRS) can be used as a quantitative marker of gas exchange in interstitial lung disease (ILD). The ratio of the uptake of 129Xe in the red blood cells to the tissue/plasma (RBC:TP) has been shown to be reduced by 70% in idiopathic pulmonary fibrosis (IPF) patients when compared with healthy volunteers (Kaushik, S.S. et al. J Appl Physiol 2014; 117:577-585). In IPF, a significant decline in 129Xe RBC:TP over 12 months has been demonstrated but no significant change in DLCO or KCO (Weatherley, N.D. et al. Thorax 2018 [Epub ahead of print]).

Aim: To compare longitudinal changes in 129Xe RBC:TP with changes in FVC and DLCO between ILD subtypes.

Methods: A prospective, multicentre study of ILD patients including drug induced ILD (DI-ILD), hypersensitivity pneumonitis (HP), IPF and connective tissue disease ILD (CTD-ILD). Hyperpolarised 129Xe MRS was performed on a 1.5 T scanner.

Results: To date, 18 patients (5 DI-ILD, 5 HP, 6 IPF, 2 CTD-ILD) have undergone 129Xe MRS on two separate visits (6 weeks apart for DI-ILD/HP and 6 months apart for IPF/CTD-ILD). There was a significant difference in longitudinal change in RBC:TP between the HP and IPF groups (p=0.022). Median change in RBC:TP in the HP and IPF groups was 0.022 and -0.023 respectively. There was no significant difference in longitudinal change in FVC% predicted (p=0.79) or DLCO% predicted (p=0.39) between the ILD subtypes.

Conclusions: Our findings demonstrate that 129Xe RBC:TP has sensitivity to longitudinal change with significant differences between IPF and HP patients, whilst FVC and DLCO showed no change, suggesting that RBC:TP is more sensitive to change than PFTs in ILD.

Original language	English
Article number	PA3158
Journal	European Respiratory Journal
Volume	54
Issue number	Suppl 63
DOIs	https://doi.org/10.1183/13993003.congress-2019.PA3158
Publication status	Published online - 21 Nov 2019

Bibliographical note

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

Access to Document

10.1183/13993003.congress-2019.PA3158

Cite this

Eaden, J., Hughes, P., Collier, G., Norquay, G., Weatherly, N., Austin, M., Smith, L., Lithgow, J., Swift, A., Renshaw, S., Buch, M., Leonard, C., Skeoch, S., Chaudhuri, N., Parker, G., Bianchi, S., & Wild, J. (2019). Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease. European Respiratory Journal, 54(Suppl 63), Article PA3158. Advance online publication. https://doi.org/10.1183/13993003.congress-2019.PA3158

@article{6b394ecf479f4c1d88a8c7510839be67,

title = "Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease",

abstract = "Introduction: Hyperpolarised 129-xenon (129Xe) MR spectroscopy (MRS) can be used as a quantitative marker of gas exchange in interstitial lung disease (ILD). The ratio of the uptake of 129Xe in the red blood cells to the tissue/plasma (RBC:TP) has been shown to be reduced by 70\% in idiopathic pulmonary fibrosis (IPF) patients when compared with healthy volunteers (Kaushik, S.S. et al. J Appl Physiol 2014; 117:577-585). In IPF, a significant decline in 129Xe RBC:TP over 12 months has been demonstrated but no significant change in DLCO or KCO (Weatherley, N.D. et al. Thorax 2018 [Epub ahead of print]). Aim: To compare longitudinal changes in 129Xe RBC:TP with changes in FVC and DLCO between ILD subtypes. Methods: A prospective, multicentre study of ILD patients including drug induced ILD (DI-ILD), hypersensitivity pneumonitis (HP), IPF and connective tissue disease ILD (CTD-ILD). Hyperpolarised 129Xe MRS was performed on a 1.5 T scanner. Results: To date, 18 patients (5 DI-ILD, 5 HP, 6 IPF, 2 CTD-ILD) have undergone 129Xe MRS on two separate visits (6 weeks apart for DI-ILD/HP and 6 months apart for IPF/CTD-ILD). There was a significant difference in longitudinal change in RBC:TP between the HP and IPF groups (p=0.022). Median change in RBC:TP in the HP and IPF groups was 0.022 and -0.023 respectively. There was no significant difference in longitudinal change in FVC\% predicted (p=0.79) or DLCO\% predicted (p=0.39) between the ILD subtypes. Conclusions: Our findings demonstrate that 129Xe RBC:TP has sensitivity to longitudinal change with significant differences between IPF and HP patients, whilst FVC and DLCO showed no change, suggesting that RBC:TP is more sensitive to change than PFTs in ILD.",

author = "James Eaden and Paul Hughes and Guilhem Collier and Graham Norquay and Nicholas Weatherly and Matthew Austin and Laurie Smith and Jim Lithgow and Andrew Swift and Stephen Renshaw and Maya Buch and Colm Leonard and Sarah Skeoch and Nazia Chaudhuri and Geoff Parker and Stephen Bianchi and Jim Wild",

note = "This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).",

year = "2019",

month = nov,

day = "21",

doi = "10.1183/13993003.congress-2019.PA3158",

language = "English",

volume = "54",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "Suppl 63",

}

Eaden, J, Hughes, P, Collier, G, Norquay, G, Weatherly, N, Austin, M, Smith, L, Lithgow, J, Swift, A, Renshaw, S, Buch, M, Leonard, C, Skeoch, S, Chaudhuri, N, Parker, G, Bianchi, S & Wild, J 2019, 'Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease', European Respiratory Journal, vol. 54, no. Suppl 63, PA3158. https://doi.org/10.1183/13993003.congress-2019.PA3158

TY - JOUR

T1 - Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease

AU - Eaden, James

AU - Hughes, Paul

AU - Collier, Guilhem

AU - Norquay, Graham

AU - Weatherly, Nicholas

AU - Austin, Matthew

AU - Smith, Laurie

AU - Lithgow, Jim

AU - Swift, Andrew

AU - Renshaw, Stephen

AU - Buch, Maya

AU - Leonard, Colm

AU - Skeoch, Sarah

AU - Chaudhuri, Nazia

AU - Parker, Geoff

AU - Bianchi, Stephen

AU - Wild, Jim

N1 - This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

PY - 2019/11/21

Y1 - 2019/11/21

N2 - Introduction: Hyperpolarised 129-xenon (129Xe) MR spectroscopy (MRS) can be used as a quantitative marker of gas exchange in interstitial lung disease (ILD). The ratio of the uptake of 129Xe in the red blood cells to the tissue/plasma (RBC:TP) has been shown to be reduced by 70% in idiopathic pulmonary fibrosis (IPF) patients when compared with healthy volunteers (Kaushik, S.S. et al. J Appl Physiol 2014; 117:577-585). In IPF, a significant decline in 129Xe RBC:TP over 12 months has been demonstrated but no significant change in DLCO or KCO (Weatherley, N.D. et al. Thorax 2018 [Epub ahead of print]). Aim: To compare longitudinal changes in 129Xe RBC:TP with changes in FVC and DLCO between ILD subtypes. Methods: A prospective, multicentre study of ILD patients including drug induced ILD (DI-ILD), hypersensitivity pneumonitis (HP), IPF and connective tissue disease ILD (CTD-ILD). Hyperpolarised 129Xe MRS was performed on a 1.5 T scanner. Results: To date, 18 patients (5 DI-ILD, 5 HP, 6 IPF, 2 CTD-ILD) have undergone 129Xe MRS on two separate visits (6 weeks apart for DI-ILD/HP and 6 months apart for IPF/CTD-ILD). There was a significant difference in longitudinal change in RBC:TP between the HP and IPF groups (p=0.022). Median change in RBC:TP in the HP and IPF groups was 0.022 and -0.023 respectively. There was no significant difference in longitudinal change in FVC% predicted (p=0.79) or DLCO% predicted (p=0.39) between the ILD subtypes. Conclusions: Our findings demonstrate that 129Xe RBC:TP has sensitivity to longitudinal change with significant differences between IPF and HP patients, whilst FVC and DLCO showed no change, suggesting that RBC:TP is more sensitive to change than PFTs in ILD.

AB - Introduction: Hyperpolarised 129-xenon (129Xe) MR spectroscopy (MRS) can be used as a quantitative marker of gas exchange in interstitial lung disease (ILD). The ratio of the uptake of 129Xe in the red blood cells to the tissue/plasma (RBC:TP) has been shown to be reduced by 70% in idiopathic pulmonary fibrosis (IPF) patients when compared with healthy volunteers (Kaushik, S.S. et al. J Appl Physiol 2014; 117:577-585). In IPF, a significant decline in 129Xe RBC:TP over 12 months has been demonstrated but no significant change in DLCO or KCO (Weatherley, N.D. et al. Thorax 2018 [Epub ahead of print]). Aim: To compare longitudinal changes in 129Xe RBC:TP with changes in FVC and DLCO between ILD subtypes. Methods: A prospective, multicentre study of ILD patients including drug induced ILD (DI-ILD), hypersensitivity pneumonitis (HP), IPF and connective tissue disease ILD (CTD-ILD). Hyperpolarised 129Xe MRS was performed on a 1.5 T scanner. Results: To date, 18 patients (5 DI-ILD, 5 HP, 6 IPF, 2 CTD-ILD) have undergone 129Xe MRS on two separate visits (6 weeks apart for DI-ILD/HP and 6 months apart for IPF/CTD-ILD). There was a significant difference in longitudinal change in RBC:TP between the HP and IPF groups (p=0.022). Median change in RBC:TP in the HP and IPF groups was 0.022 and -0.023 respectively. There was no significant difference in longitudinal change in FVC% predicted (p=0.79) or DLCO% predicted (p=0.39) between the ILD subtypes. Conclusions: Our findings demonstrate that 129Xe RBC:TP has sensitivity to longitudinal change with significant differences between IPF and HP patients, whilst FVC and DLCO showed no change, suggesting that RBC:TP is more sensitive to change than PFTs in ILD.

U2 - 10.1183/13993003.congress-2019.PA3158

DO - 10.1183/13993003.congress-2019.PA3158

M3 - Conference article

SN - 0903-1936

VL - 54

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - Suppl 63

M1 - PA3158

ER -

Longitudinal change in hyperpolarised 129-xenon MR spectroscopy in interstitial lung disease

Abstract

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