Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis

Jennifer Deane, Mary C Rea, Fiona Fouhy, Catherine Stanton, R Paul Ross, Barry J Plant

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1 Citation (Scopus)

    Abstract

    Since the commercialization of antibiotics in the 1940s, life expectancy has increased in parallel with their discovery. However, concerns regarding the collateral effects of antibiotic therapy on gut microbiota composition and functionality within the host have come to the fore. Antibiotic therapy disrupts the normal ecology of the gut microbiome, resulting in altered composition, and in some cases function. Cystic fibrosis (CF) is an ideal candidate group in which to examine antibiotic effects on the gut microbiota. Chronic antibiotic use, along with the typical high-fat CF diet, cystic fibrosis transmembrane conductance regulator malfunction itself, pancreatic enzyme supplementation, and suppression of gastric acid, play a key role in defining the unique composition of the CF intestinal microbiota. Most available studies focus on the short-term effects of an antibiotic course of limited duration (eg, 7 days) and the pattern of recovery after such treatments. Here we discuss the specific effects of different antibiotic families on the gut microbiota. We examine the multidrug-resistant, Clostridium difficile, and antibiotic-associated diarrhea risk and prevalence associated with chronic antibiotic use. We review the success to date of probiotics to ameliorate CF symptomology. Finally, we explore alternative therapies for infection control currently under research.
    LanguageEnglish
    Title of host publicationThe brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota
    PublisherElsevier
    Pages223-259
    Volume1
    ISBN (Print)978-0-12-802304-4
    DOIs
    Publication statusAccepted/In press - 1 May 2016

    Fingerprint

    Cystic Fibrosis
    Anti-Bacterial Agents
    Health
    Population
    Gastrointestinal Microbiome
    Cystic Fibrosis Transmembrane Conductance Regulator
    Clostridium difficile
    Gastric Acid
    Probiotics
    Complementary Therapies
    Infection Control
    Life Expectancy
    Ecology
    Diarrhea
    Therapeutics
    Fats
    Diet
    Enzymes
    Research

    Keywords

    • Antibiotics
    • C. difficile
    • Cystic fibrosis
    • Gut microbiota
    • Multidrug resistance
    • Probiotics

    Cite this

    Deane, J., Rea, M. C., Fouhy, F., Stanton, C., Ross, R. P., & Plant, B. J. (Accepted/In press). Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis. In The brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota (Vol. 1, pp. 223-259). Elsevier. https://doi.org/10.1016/B978-0-12-802304-4.00011-6
    Deane, Jennifer ; Rea, Mary C ; Fouhy, Fiona ; Stanton, Catherine ; Ross, R Paul ; Plant, Barry J. / Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis. The brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota. Vol. 1 Elsevier, 2016. pp. 223-259
    @inbook{8555443f3a23401baac10df96fa500ae,
    title = "Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis",
    abstract = "Since the commercialization of antibiotics in the 1940s, life expectancy has increased in parallel with their discovery. However, concerns regarding the collateral effects of antibiotic therapy on gut microbiota composition and functionality within the host have come to the fore. Antibiotic therapy disrupts the normal ecology of the gut microbiome, resulting in altered composition, and in some cases function. Cystic fibrosis (CF) is an ideal candidate group in which to examine antibiotic effects on the gut microbiota. Chronic antibiotic use, along with the typical high-fat CF diet, cystic fibrosis transmembrane conductance regulator malfunction itself, pancreatic enzyme supplementation, and suppression of gastric acid, play a key role in defining the unique composition of the CF intestinal microbiota. Most available studies focus on the short-term effects of an antibiotic course of limited duration (eg, 7 days) and the pattern of recovery after such treatments. Here we discuss the specific effects of different antibiotic families on the gut microbiota. We examine the multidrug-resistant, Clostridium difficile, and antibiotic-associated diarrhea risk and prevalence associated with chronic antibiotic use. We review the success to date of probiotics to ameliorate CF symptomology. Finally, we explore alternative therapies for infection control currently under research.",
    keywords = "Antibiotics, C. difficile, Cystic fibrosis, Gut microbiota, Multidrug resistance, Probiotics",
    author = "Jennifer Deane and Rea, {Mary C} and Fiona Fouhy and Catherine Stanton and Ross, {R Paul} and Plant, {Barry J}",
    year = "2016",
    month = "5",
    day = "1",
    doi = "10.1016/B978-0-12-802304-4.00011-6",
    language = "English",
    isbn = "978-0-12-802304-4",
    volume = "1",
    pages = "223--259",
    booktitle = "The brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota",
    publisher = "Elsevier",
    address = "Netherlands",

    }

    Deane, J, Rea, MC, Fouhy, F, Stanton, C, Ross, RP & Plant, BJ 2016, Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis. in The brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota. vol. 1, Elsevier, pp. 223-259. https://doi.org/10.1016/B978-0-12-802304-4.00011-6

    Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis. / Deane, Jennifer; Rea, Mary C; Fouhy, Fiona; Stanton, Catherine; Ross, R Paul; Plant, Barry J.

    The brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota. Vol. 1 Elsevier, 2016. p. 223-259.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    TY - CHAP

    T1 - Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis

    AU - Deane, Jennifer

    AU - Rea, Mary C

    AU - Fouhy, Fiona

    AU - Stanton, Catherine

    AU - Ross, R Paul

    AU - Plant, Barry J

    PY - 2016/5/1

    Y1 - 2016/5/1

    N2 - Since the commercialization of antibiotics in the 1940s, life expectancy has increased in parallel with their discovery. However, concerns regarding the collateral effects of antibiotic therapy on gut microbiota composition and functionality within the host have come to the fore. Antibiotic therapy disrupts the normal ecology of the gut microbiome, resulting in altered composition, and in some cases function. Cystic fibrosis (CF) is an ideal candidate group in which to examine antibiotic effects on the gut microbiota. Chronic antibiotic use, along with the typical high-fat CF diet, cystic fibrosis transmembrane conductance regulator malfunction itself, pancreatic enzyme supplementation, and suppression of gastric acid, play a key role in defining the unique composition of the CF intestinal microbiota. Most available studies focus on the short-term effects of an antibiotic course of limited duration (eg, 7 days) and the pattern of recovery after such treatments. Here we discuss the specific effects of different antibiotic families on the gut microbiota. We examine the multidrug-resistant, Clostridium difficile, and antibiotic-associated diarrhea risk and prevalence associated with chronic antibiotic use. We review the success to date of probiotics to ameliorate CF symptomology. Finally, we explore alternative therapies for infection control currently under research.

    AB - Since the commercialization of antibiotics in the 1940s, life expectancy has increased in parallel with their discovery. However, concerns regarding the collateral effects of antibiotic therapy on gut microbiota composition and functionality within the host have come to the fore. Antibiotic therapy disrupts the normal ecology of the gut microbiome, resulting in altered composition, and in some cases function. Cystic fibrosis (CF) is an ideal candidate group in which to examine antibiotic effects on the gut microbiota. Chronic antibiotic use, along with the typical high-fat CF diet, cystic fibrosis transmembrane conductance regulator malfunction itself, pancreatic enzyme supplementation, and suppression of gastric acid, play a key role in defining the unique composition of the CF intestinal microbiota. Most available studies focus on the short-term effects of an antibiotic course of limited duration (eg, 7 days) and the pattern of recovery after such treatments. Here we discuss the specific effects of different antibiotic families on the gut microbiota. We examine the multidrug-resistant, Clostridium difficile, and antibiotic-associated diarrhea risk and prevalence associated with chronic antibiotic use. We review the success to date of probiotics to ameliorate CF symptomology. Finally, we explore alternative therapies for infection control currently under research.

    KW - Antibiotics

    KW - C. difficile

    KW - Cystic fibrosis

    KW - Gut microbiota

    KW - Multidrug resistance

    KW - Probiotics

    U2 - 10.1016/B978-0-12-802304-4.00011-6

    DO - 10.1016/B978-0-12-802304-4.00011-6

    M3 - Chapter

    SN - 978-0-12-802304-4

    VL - 1

    SP - 223

    EP - 259

    BT - The brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota

    PB - Elsevier

    ER -

    Deane J, Rea MC, Fouhy F, Stanton C, Ross RP, Plant BJ. Long-Term Implications of Antibiotic Use on Gut Health and Microbiota in Populations Including Patients With Cystic Fibrosis. In The brain-gut axis- Dietary, Probiotic, and Prebiotic Interventions on the Microbiota. Vol. 1. Elsevier. 2016. p. 223-259 https://doi.org/10.1016/B978-0-12-802304-4.00011-6