Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

DW Porter; Peter Flatt; Christian Holscher; Victor Gault

doi:10.1038/ijo.2012.91

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

DW Porter, Peter Flatt, Christian Holscher, Victor Gault

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P

Original language	English
Pages (from-to)	678-684
Journal	International Journal of Obesity
Volume	37
Issue number	5
DOIs	https://doi.org/10.1038/ijo.2012.91
Publication status	Published (in print/issue) - 5 Jun 2013

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10.1038/ijo.2012.91

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abstract = "Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P",

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AU - Flatt, Peter

AU - Holscher, Christian

AU - Gault, Victor

PY - 2013/6/5

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AB - Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P

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JF - International Journal of Obesity

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Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

Abstract

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