Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

DW Porter, Peter Flatt, Christian Holscher, Victor Gault

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P
LanguageEnglish
Pages678-684
JournalInternational Journal of Obesity
Volume37
Issue number5
DOIs
Publication statusPublished - 5 Jun 2013

Fingerprint

Neuronal Plasticity
Glucagon-Like Peptide 1
Long-Term Potentiation
High Fat Diet
Cognition
Obesity
Learning
Gene Expression
Liraglutide

Cite this

@article{beebebd752914eafaed4ad3c46e7238e,
title = "Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.",
abstract = "Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P",
author = "DW Porter and Peter Flatt and Christian Holscher and Victor Gault",
year = "2013",
month = "6",
day = "5",
doi = "10.1038/ijo.2012.91",
language = "English",
volume = "37",
pages = "678--684",
journal = "International Journal of Obesity",
issn = "0307-0565",
number = "5",

}

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice. / Porter, DW; Flatt, Peter; Holscher, Christian; Gault, Victor.

In: International Journal of Obesity, Vol. 37, No. 5, 05.06.2013, p. 678-684.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

AU - Porter, DW

AU - Flatt, Peter

AU - Holscher, Christian

AU - Gault, Victor

PY - 2013/6/5

Y1 - 2013/6/5

N2 - Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P

AB - Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P

U2 - 10.1038/ijo.2012.91

DO - 10.1038/ijo.2012.91

M3 - Article

VL - 37

SP - 678

EP - 684

JO - International Journal of Obesity

T2 - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 5

ER -