Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice.

DW Porter, Peter Flatt, Christian Holscher, Victor Gault

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P
Original languageEnglish
Pages (from-to)678-684
JournalInternational Journal of Obesity
Volume37
Issue number5
DOIs
Publication statusPublished - 5 Jun 2013

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