Liposome mimicking polymersomes; A comparative study of the merits of polymersomes in terms of formulation and stability

Noorjahan Aibani, Talat Khan, Bridgeen Callan

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34 Citations (Scopus)
145 Downloads (Pure)


The past few decades have seen a significant rise in research into alternative polymer based nanosized unilamellar drug delivery systems, termed polymersomes. The reported benefits of polymersomes over the more traditional liposomes include increased stability, higher encapsulation efficacies, better adaptability and reduced water permeation due to an increased bilayer thickness. Together, these advantages render them suitable for a plethora of therapies. The work presented in this manuscript creates and compares four such drug delivery systems, two based on the traditional liposome and two prepared from amphiphilic polymers. From there we assess these systems in terms of size, stability, encapsulation efficiency, drug release, cellular toxicity and cellular uptake. We can confirm from this comprehensive investigation that the multi-functional synthetic polymersomes are undoubtedly a future contender in this expanding field of nanomedicines. Their ability to encapsulate a cocktail of different compounds, high stability as well as their ease of adaptability will ensure that they feature prominently in the future of advanced drug delivery systems.
Original languageEnglish
Article number100040
Pages (from-to)100040
Number of pages9
JournalInternational Journal of Pharmaceutics X
Early online date31 Dec 2019
Publication statusPublished (in print/issue) - 31 Dec 2020

Bibliographical note

Funding Information:
TNK and NA would like to thank Ulster University for their Vice-Chancellor research studentships

Publisher Copyright:
© 2019

Copyright 2020 Elsevier B.V., All rights reserved.


  • Polymersomes
  • Liposomes
  • Amphiphilic polymers
  • Comparative study
  • In-vitro investigation


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