TY - JOUR
T1 - Letter to the editor: CURRENT BIOLOGICAL AND PHARMACOLOGICAL UPDATES ON WOGONIN
AU - Rawat, Sarita
AU - Gupta, Gaurav
AU - Pathak, Sachchidanand
AU - Singh, Santosh Kumar
AU - Singh, Himmat
AU - Mishra, Anurag
AU - Gilhotra, Ritu
AU - Aljabali, Alaa A. A.
AU - Dureja, Harish
AU - Tambuwala, Murtaza M.
AU - Chellappan, Dinesh K.
AU - Dua, Kamal
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5/13
Y1 - 2020/5/13
N2 - Wogonin (5, 7-Dihydroxy-8-methoxy flavone) is a traditional naturally occurring flavonoid derived from the root extract of Chinese medicine, named Scutellaria baicalensis Georgi. Wogonin contains various biological properties which include allergic diseases, anti-cancer therapy, and anti-inflammatory activities. Wogonin also shows the effects of removing toxins and cleansing the heart (Ancuceanu et al., 2019[1]). The anticancer therapeutic activity of wogonin has been shown by the regulation of different cell signaling pathways, which includes protein kinase B pathway (serine-threonine kinase) and AMP-activated protein kinase pathways (Bei et al., 2020[2]). Wogonin also shows positive therapeutic anticancer effects in breast cancer by inhibiting the 5-LO/BLT2/ERK/IL-8/MMP-9 signaling cascade and establishes a major pharmacological anticancer activity (Bibi et al., 2019[3]). Current biological and pharmacological updates on wogonin have been reviewed (Table 1(Tab. 1); References in Table 1: Du et al., 2019[4]; Ewendt and Foller, 2019[5]; Fang et al., 2019[6]; Gao et al., 2019[7]; Gharari et al., 2020[8]; Hanioka et al., 2020[9]; Hong et al., 2020[10]; Huang et al., 2020[11]; Jiang et al., 2019[12]; Jiao et al., 2019[13]; Khan and Kamal, 2019[14][15]; Khushdil et al., 2019[16]; Kim et al., 2019[17]; Kong et al., 2019[18]; Liang et al., 2019[19]; Liau et al., 2019[20]; Luo et al., 2019[21]; Oomen et al., 2020[22]; Tan et al., 2019[23]; Wang and Cui, 2019[24]; Wang et al., 2019[25][26]; Wang et al., 2020[27]; Xing et al., 2019[28][29]; Zhang et al., 2019[30]).
AB - Wogonin (5, 7-Dihydroxy-8-methoxy flavone) is a traditional naturally occurring flavonoid derived from the root extract of Chinese medicine, named Scutellaria baicalensis Georgi. Wogonin contains various biological properties which include allergic diseases, anti-cancer therapy, and anti-inflammatory activities. Wogonin also shows the effects of removing toxins and cleansing the heart (Ancuceanu et al., 2019[1]). The anticancer therapeutic activity of wogonin has been shown by the regulation of different cell signaling pathways, which includes protein kinase B pathway (serine-threonine kinase) and AMP-activated protein kinase pathways (Bei et al., 2020[2]). Wogonin also shows positive therapeutic anticancer effects in breast cancer by inhibiting the 5-LO/BLT2/ERK/IL-8/MMP-9 signaling cascade and establishes a major pharmacological anticancer activity (Bibi et al., 2019[3]). Current biological and pharmacological updates on wogonin have been reviewed (Table 1(Tab. 1); References in Table 1: Du et al., 2019[4]; Ewendt and Foller, 2019[5]; Fang et al., 2019[6]; Gao et al., 2019[7]; Gharari et al., 2020[8]; Hanioka et al., 2020[9]; Hong et al., 2020[10]; Huang et al., 2020[11]; Jiang et al., 2019[12]; Jiao et al., 2019[13]; Khan and Kamal, 2019[14][15]; Khushdil et al., 2019[16]; Kim et al., 2019[17]; Kong et al., 2019[18]; Liang et al., 2019[19]; Liau et al., 2019[20]; Luo et al., 2019[21]; Oomen et al., 2020[22]; Tan et al., 2019[23]; Wang and Cui, 2019[24]; Wang et al., 2019[25][26]; Wang et al., 2020[27]; Xing et al., 2019[28][29]; Zhang et al., 2019[30]).
UR - http://www.scopus.com/inward/record.url?scp=85096845969&partnerID=8YFLogxK
U2 - 10.17179/excli2020-1967
DO - 10.17179/excli2020-1967
M3 - Letter
SN - 1611-2156
VL - 19
SP - 635
EP - 640
JO - EXCLI
JF - EXCLI
ER -