Lasered Graphene Microheaters Modified with Phase-Change Composites: New Approach to Smart Patch Drug Delivery

Victoria Gilpin, Deetchaya Surandhiran, Cameron Scott, Amy Devine, Jill Cundell, Chris IR Gill, L. Kirsty Pourshahidi, J Davis

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Abstract

The combination of paraffin wax and O,O′-bis(2-aminopropyl) polypropylene glycol–block–polyethylene glycol–block–polypropylene glycol was used as a phase-change material (PCM) for the controlled delivery of curcumin. The PCM was combined with a graphene-based heater derived from the laser scribing of polyimide film. This assembly provides a new approach to a smart patch through which release can be electronically controlled, allowing repetitive dosing. Rather than relying on passive diffusion, delivery is induced and terminated through the controlled heating of the PCM with transfer only occurring when the PCM transitions from solid to liquid. The material properties of the device and release characteristics of the strategy under repetitive dosing are critically assessed. The delivery yield of curcumin was found to be 3.5 µg (4.5 µg/cm2) per 3 min thermal cycle.
Original languageEnglish
Article number1132
Pages (from-to)e1132
Number of pages14
JournalMicromachines
Volume13
Issue number7
DOIs
Publication statusPublished - 18 Jul 2022

Bibliographical note

The research was support by the Department for the Economy Northern Ireland.

Keywords

  • curcumin
  • laser- induced graphene(LIG)
  • smart patch
  • thermal activation
  • drug delivery
  • phase-change material
  • laser-induced graphene (LIG)

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