Lactonic Sophorolipids Increase Tumor Burden in Apcmin+/- Mice

CA MITCHELL, R Marchant, Ibrahim Banat, Helen Lydon, Breedge Callaghan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Sophorolipids (SL) are amphiphilic biosurfactant molecules consisting of a disaccharidesophorose with one fatty acid at the C1 position and optional acetylation at the C6’and C6”positions. They exist in a closed ring lactonic (LSL) or open acidic (ASL) structure Sophorolipidsare produced in crude mixtures in economically viable amounts by the yeast Starmerellabombicola and used in a variety of consumer products. Varying levels of antiproliferativeand anti-cancer activity of crude sophorolipid mixtures are described in a number of tumor cell lines in vitro. However, significant inter-study variation exists in the composition of sophorolipid species as well as other biologically active compounds in these mixtures, which makes interpretation of in vitro and in vivo studies difficult.We produced a 96% pure C18:1 lactonic sophorolipid that dose-dependently reduces the viability of colorectal cancer, as well as normal human colonic and lung cell lines in vitro. Oral administration of vehicle-only; or lactonic sophorolipids (50 mg/kg for 70 days), toApcmin+/- mice resulted in an increase in the number (55.5 ± 3.3 vs 70.50 ± 7.8: p <0.05)and size (modal size 2mm vs 4mm) of intestinal polyps. Lactonic administration resulted in a systematic effect via reduced hematocrit (49.5 ± 1.0 vs 28.2 ± 2.0 vs: p
LanguageEnglish
JournalPLoS ONE
Volume11
DOIs
Publication statusPublished - 6 Jun 2016

Fingerprint

sophorolipids
Tumor Burden
Tumors
neoplasms
mice
Intestinal Polyps
Cells
Acetylation
Consumer products
Tumor Cell Line
Hematocrit
Yeast
Oral Administration
cell lines
Colorectal Neoplasms
biosurfactants
Fatty Acids
Yeasts
acetylation
Cell Line

Keywords

  • Sophorolipids
  • Acidic
  • Colorectal cancer
  • Apcmin+/-
  • Caco-2 cells
  • HT29 cells
  • apoptosis
  • spleen
  • cancer treatment
  • mouse models
  • gastrointestinal tract

Cite this

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Lactonic Sophorolipids Increase Tumor Burden in Apcmin+/- Mice. / MITCHELL, CA; Marchant, R; Banat, Ibrahim; Lydon, Helen; Callaghan, Breedge.

In: PLoS ONE, Vol. 11, 06.06.2016.

Research output: Contribution to journalArticle

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