Kinetics and thermodynamics of G-quadruplexes.

Julien Gros; Mateus Webba da Silva; Anne De Cian; Samir Amrane; Frederic Rosu; Anne Bourdoncle; Barbara Sacca; Patrizia Alberti; Laurent Lacroix; Jean-Louis Mergny

doi:10.1093/nass/49.1.61

Kinetics and thermodynamics of G-quadruplexes.

Julien Gros
, Mateus Webba da Silva
, Anne De Cian
, Samir Amrane
, Frederic Rosu
, Anne Bourdoncle
, Barbara Sacca
, Patrizia Alberti
, Laurent Lacroix
, Jean-Louis Mergny

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine. Results were compared with the canonical TG4T and TG5T tetramers: we demonstrate huge differences (up to 105-fold) in the association constants of these quadruplexes depending on primary sequence.

Original language	English
Pages (from-to)	61-62
Number of pages	2
Journal	Nucleic Acids Symposium Series (Online)
Volume	49
Issue number	1
DOIs	https://doi.org/10.1093/nass/49.1.61
Publication status	Published (in print/issue) - 1 Sept 2005

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10.1093/nass/49.1.61

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title = "Kinetics and thermodynamics of G-quadruplexes.",

abstract = "The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine. Results were compared with the canonical TG4T and TG5T tetramers: we demonstrate huge differences (up to 105-fold) in the association constants of these quadruplexes depending on primary sequence.",

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AU - Gros, Julien

AU - Webba da Silva, Mateus

AU - De Cian, Anne

AU - Amrane, Samir

AU - Rosu, Frederic

AU - Bourdoncle, Anne

AU - Sacca, Barbara

AU - Alberti, Patrizia

AU - Lacroix, Laurent

AU - Mergny, Jean-Louis

PY - 2005/9/1

Y1 - 2005/9/1

N2 - The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine. Results were compared with the canonical TG4T and TG5T tetramers: we demonstrate huge differences (up to 105-fold) in the association constants of these quadruplexes depending on primary sequence.

AB - The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However, rather than being a hindrance, this kinetic inertia allows us to study association and dissociation processes independently. General rules have been extended to longer DNA motifs or sequences containing modified bases such as 8-oxo or 7-deaza guanine. Results were compared with the canonical TG4T and TG5T tetramers: we demonstrate huge differences (up to 105-fold) in the association constants of these quadruplexes depending on primary sequence.

U2 - 10.1093/nass/49.1.61

DO - 10.1093/nass/49.1.61

M3 - Article

SN - 1746-8272

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EP - 62

JO - Nucleic Acids Symposium Series (Online)

JF - Nucleic Acids Symposium Series (Online)

IS - 1

ER -

Kinetics and thermodynamics of G-quadruplexes.

Abstract

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