Juvenile idiopathic arthritis: Synovial predictors of outcome

Laura Pascoli, Sarah Blelock, Catherine McAllister, Susan Clarke, David Gibson, Madeleine Rooney

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Background: Juvenile idiopathic arthritis runs an unpredictable course. Childrenwith oligoarticular disease may respond well to intra-articular steroids or haverecurrent episodes of synovitis. Children with polyarticular disease may respond toMethotrexate or require steroids and/or biologics. Currently there are no reliablepredictors of outcome in early disease, which leads to sub-optimal treatment.Methods: We are currently undertaking a five-year prospective study of childrenwith newly diagnosed and untreated JIA. All have knee involvement. At outset,we obtain synovial biopsies (N¼5) under ultrasound guidance. We then recorddetailed clinical, functional, radiological and laboratory data every 3/12 for twoyears. We are correlating outcomes at one and two years with synovial findingsrecorded at outset. Here we report on those children whom to date we havefollowed for one year.Results: Of the first 30 children, 18 had oligoarticular disease. Their diseaseactivity score fell from a mean of 3.54 to 1.12 at one year. Ten had a single episodeof swelling of the index joint while eight had 2 or more episodes.Twelve had polyarticular disease. All but two were improved at one year.The mean ESR fell from 44 to 13, and CRP from 33 to 5. Haemoglobin rose froma mean of 10.6 mg/dl to 12.5 mg/dl. The CHAQ improved in all but two.We found significantly more synovial pathology in the poly compared with oligopatients, with mean vessel score 6.9 vs. 2.6 (p
    LanguageEnglish
    Title of host publicationUnknown Host Publication
    Pagesii26
    Number of pages1
    Volume47
    Publication statusPublished - 2008
    EventBritish Society for Rheumatology - Liverpool
    Duration: 1 Jan 2008 → …

    Conference

    ConferenceBritish Society for Rheumatology
    Period1/01/08 → …

    Fingerprint

    Juvenile Arthritis
    Joints
    Steroids
    Synovitis
    Biological Products
    Knee
    Hemoglobins
    Prospective Studies
    Pathology
    Biopsy

    Keywords

    • juvenile arthritis
    • synovial histopathology
    • synovial biopsy

    Cite this

    Pascoli, L., Blelock, S., McAllister, C., Clarke, S., Gibson, D., & Rooney, M. (2008). Juvenile idiopathic arthritis: Synovial predictors of outcome. In Unknown Host Publication (Vol. 47, pp. ii26)
    Pascoli, Laura ; Blelock, Sarah ; McAllister, Catherine ; Clarke, Susan ; Gibson, David ; Rooney, Madeleine. / Juvenile idiopathic arthritis: Synovial predictors of outcome. Unknown Host Publication. Vol. 47 2008. pp. ii26
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    Pascoli, L, Blelock, S, McAllister, C, Clarke, S, Gibson, D & Rooney, M 2008, Juvenile idiopathic arthritis: Synovial predictors of outcome. in Unknown Host Publication. vol. 47, pp. ii26, British Society for Rheumatology, 1/01/08.

    Juvenile idiopathic arthritis: Synovial predictors of outcome. / Pascoli, Laura; Blelock, Sarah; McAllister, Catherine; Clarke, Susan; Gibson, David; Rooney, Madeleine.

    Unknown Host Publication. Vol. 47 2008. p. ii26.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

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    AU - Pascoli, Laura

    AU - Blelock, Sarah

    AU - McAllister, Catherine

    AU - Clarke, Susan

    AU - Gibson, David

    AU - Rooney, Madeleine

    PY - 2008

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    N2 - Background: Juvenile idiopathic arthritis runs an unpredictable course. Childrenwith oligoarticular disease may respond well to intra-articular steroids or haverecurrent episodes of synovitis. Children with polyarticular disease may respond toMethotrexate or require steroids and/or biologics. Currently there are no reliablepredictors of outcome in early disease, which leads to sub-optimal treatment.Methods: We are currently undertaking a five-year prospective study of childrenwith newly diagnosed and untreated JIA. All have knee involvement. At outset,we obtain synovial biopsies (N¼5) under ultrasound guidance. We then recorddetailed clinical, functional, radiological and laboratory data every 3/12 for twoyears. We are correlating outcomes at one and two years with synovial findingsrecorded at outset. Here we report on those children whom to date we havefollowed for one year.Results: Of the first 30 children, 18 had oligoarticular disease. Their diseaseactivity score fell from a mean of 3.54 to 1.12 at one year. Ten had a single episodeof swelling of the index joint while eight had 2 or more episodes.Twelve had polyarticular disease. All but two were improved at one year.The mean ESR fell from 44 to 13, and CRP from 33 to 5. Haemoglobin rose froma mean of 10.6 mg/dl to 12.5 mg/dl. The CHAQ improved in all but two.We found significantly more synovial pathology in the poly compared with oligopatients, with mean vessel score 6.9 vs. 2.6 (p

    AB - Background: Juvenile idiopathic arthritis runs an unpredictable course. Childrenwith oligoarticular disease may respond well to intra-articular steroids or haverecurrent episodes of synovitis. Children with polyarticular disease may respond toMethotrexate or require steroids and/or biologics. Currently there are no reliablepredictors of outcome in early disease, which leads to sub-optimal treatment.Methods: We are currently undertaking a five-year prospective study of childrenwith newly diagnosed and untreated JIA. All have knee involvement. At outset,we obtain synovial biopsies (N¼5) under ultrasound guidance. We then recorddetailed clinical, functional, radiological and laboratory data every 3/12 for twoyears. We are correlating outcomes at one and two years with synovial findingsrecorded at outset. Here we report on those children whom to date we havefollowed for one year.Results: Of the first 30 children, 18 had oligoarticular disease. Their diseaseactivity score fell from a mean of 3.54 to 1.12 at one year. Ten had a single episodeof swelling of the index joint while eight had 2 or more episodes.Twelve had polyarticular disease. All but two were improved at one year.The mean ESR fell from 44 to 13, and CRP from 33 to 5. Haemoglobin rose froma mean of 10.6 mg/dl to 12.5 mg/dl. The CHAQ improved in all but two.We found significantly more synovial pathology in the poly compared with oligopatients, with mean vessel score 6.9 vs. 2.6 (p

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    Pascoli L, Blelock S, McAllister C, Clarke S, Gibson D, Rooney M. Juvenile idiopathic arthritis: Synovial predictors of outcome. In Unknown Host Publication. Vol. 47. 2008. p. ii26