TY - JOUR
T1 - Isolation of [Pro2,Met13]Somatostatin-14 and somatostatin-14 from the frog brain reveals the existence of a somatostatin gene family in a tetrapod
AU - Vaudry, Hubert
AU - Chartrel, Nicolas
AU - Conlon, J. Michael
PY - 1992/10/15
Y1 - 1992/10/15
N2 - Two somatostatin-related peptides were isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the most abundant component was identical to that of mammalian somatostatin-14. The primary structure of the second component, present in approximately 5% of the abundance of somatostatin-14, was established as Ala-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Met-Cys. This sequence shows two substitutions (Pro for Gly2 and Met for Ser13) compared with mammalian somatostatin-14. The data provide evidence for a somatostatin gene family in tetrapods as well as in teleost fish.
AB - Two somatostatin-related peptides were isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the most abundant component was identical to that of mammalian somatostatin-14. The primary structure of the second component, present in approximately 5% of the abundance of somatostatin-14, was established as Ala-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Met-Cys. This sequence shows two substitutions (Pro for Gly2 and Met for Ser13) compared with mammalian somatostatin-14. The data provide evidence for a somatostatin gene family in tetrapods as well as in teleost fish.
UR - http://www.scopus.com/inward/record.url?scp=0026613765&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(92)92409-Q
DO - 10.1016/0006-291X(92)92409-Q
M3 - Article
C2 - 1358069
AN - SCOPUS:0026613765
SN - 0006-291X
VL - 188
SP - 477
EP - 482
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -