Isolation and structure of guinea pig gastric and pancreatic somatostatin

J. Michael Conlon

doi:10.1016/0024-3205(84)90142-5

Isolation and structure of guinea pig gastric and pancreatic somatostatin

J. Michael Conlon

School of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Somatostatin-14 has been isolated from guinea pig pancreas and stomach and purified to homogeneity by gel filtration, ion-exchange chromatography and reverse phase HPLC. Amino acid composition and sequence analysis indicated that guinea pig somatostatin from both tissues has the same structure as somatostatin-14 from all other mammalian species yet studied. The study has demonstrated that somatostatin-14 from gastric tissue has the same structure as the peptide from hypothalamus and pancreas.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Life Sciences
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(84)90142-5
Publication status	Published (in print/issue) - 9 Jul 1984

Funding

We thank the Volkswagen Stiftung for financial support and Professor Norbert Hilschmann, Max-Planck-Institut f6r Experimentelle Medizin, G6ttingen, for providing the facilities for amino acid analysis.

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10.1016/0024-3205(84)90142-5

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abstract = "Somatostatin-14 has been isolated from guinea pig pancreas and stomach and purified to homogeneity by gel filtration, ion-exchange chromatography and reverse phase HPLC. Amino acid composition and sequence analysis indicated that guinea pig somatostatin from both tissues has the same structure as somatostatin-14 from all other mammalian species yet studied. The study has demonstrated that somatostatin-14 from gastric tissue has the same structure as the peptide from hypothalamus and pancreas.",

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AB - Somatostatin-14 has been isolated from guinea pig pancreas and stomach and purified to homogeneity by gel filtration, ion-exchange chromatography and reverse phase HPLC. Amino acid composition and sequence analysis indicated that guinea pig somatostatin from both tissues has the same structure as somatostatin-14 from all other mammalian species yet studied. The study has demonstrated that somatostatin-14 from gastric tissue has the same structure as the peptide from hypothalamus and pancreas.

UR - https://www.scopus.com/pages/publications/0021259182

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ER -

Isolation and structure of guinea pig gastric and pancreatic somatostatin

Abstract

Funding

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