TY - JOUR
T1 - Isolation and primary structure of urotensin II from the brain of a tetrapod, the frog Rana ridibunda
AU - Conlon, J. Michael
AU - O'Harte, Finbarr
AU - Smith, D. David
AU - Tonon, Marie Christine
AU - Vaudry, Hubert
PY - 1992/10/30
Y1 - 1992/10/30
N2 - A peptide related to urotensin II has been isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the peptide was established as Ala-Gly-Asn-Leu-Ser-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Val and this sequence was confirmed by chemical synthesis. Frog urotensin II contains an additional amino acid residue compared with fish urotensin II peptides but the structure of the cyclic region of the molecule has been fully conserved. The data show that urotensin II is not confined to the caudal neurosecretory system of fish but is present in the central nervous system of a tetrapod.
AB - A peptide related to urotensin II has been isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the peptide was established as Ala-Gly-Asn-Leu-Ser-Glu-Cys-Phe-Trp-Lys-Tyr-Cys-Val and this sequence was confirmed by chemical synthesis. Frog urotensin II contains an additional amino acid residue compared with fish urotensin II peptides but the structure of the cyclic region of the molecule has been fully conserved. The data show that urotensin II is not confined to the caudal neurosecretory system of fish but is present in the central nervous system of a tetrapod.
UR - http://www.scopus.com/inward/record.url?scp=0026438883&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(92)91095-8
DO - 10.1016/0006-291X(92)91095-8
M3 - Article
C2 - 1445302
AN - SCOPUS:0026438883
SN - 0006-291X
VL - 188
SP - 578
EP - 583
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -