INVIVO STUDIES OF THE ACTION SPECTRUM AND TIME COURSE FOR RELEASE OF TRANSFORMING GROWTH FACTOR-ALPHA BY ULTRAVIOLET-IRRADIATION IN MAN

GM MURPHY, Daniel Quinn, RDR CAMP, JLM HAWK, MW GREAVES

    Research output: Contribution to journalArticle

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    Abstract

    Transforming growth factor-alpha (TGF-alpha) is a growth-promoting cytokine which enhances epithelial proliferation and is secreted by a wide variety of tumour cells. It is also present in normal human epidermis and its overproduction may be responsible for epidermal hyperproliferation in psoriasis. Ultraviolet (UV) B irradiation of human skin leads to epidermal damage and significant subsequent hyperplasia after approximately 24 h, whereas UVA irradiation has little such effect and predominantly damages the dermis. The relative efficacies of UVB and UVA in releasing TGF-alpha were studied in 10 subjects of skin types I and II using a skin-chamber technique and a specific TGF-alpha radioimmunoassay. Significantly elevated concentrations of immunoreactive TGF-alpha were detected in samples after 24 h in UVB-irradiated compared with unirradiated skin. Samples at earlier time points from UVB- and UVA-exposed skin contained measurable levels of TGF-alpha but these were not significantly elevated above the levels found in samples from unirradiated areas. These results, which suggest that UVB irradiation increases release of TGF-alpha from human skin at 24 h, indicate that TGF-alpha may be implicated in UVB-induced epidermal hyperplasia.
    LanguageEnglish
    Pages566-568
    JournalBritish Journal of Dermatology
    Volume125
    Issue number6
    DOIs
    Publication statusPublished - Dec 1991

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    Transforming Growth Factor alpha
    Skin
    Hyperplasia
    Dermis
    Psoriasis
    Epidermis
    Radioimmunoassay
    Action Spectrum
    Cytokines
    Growth
    Neoplasms

    Cite this

    MURPHY, GM ; Quinn, Daniel ; CAMP, RDR ; HAWK, JLM ; GREAVES, MW. / INVIVO STUDIES OF THE ACTION SPECTRUM AND TIME COURSE FOR RELEASE OF TRANSFORMING GROWTH FACTOR-ALPHA BY ULTRAVIOLET-IRRADIATION IN MAN. In: British Journal of Dermatology. 1991 ; Vol. 125, No. 6. pp. 566-568.
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    abstract = "Transforming growth factor-alpha (TGF-alpha) is a growth-promoting cytokine which enhances epithelial proliferation and is secreted by a wide variety of tumour cells. It is also present in normal human epidermis and its overproduction may be responsible for epidermal hyperproliferation in psoriasis. Ultraviolet (UV) B irradiation of human skin leads to epidermal damage and significant subsequent hyperplasia after approximately 24 h, whereas UVA irradiation has little such effect and predominantly damages the dermis. The relative efficacies of UVB and UVA in releasing TGF-alpha were studied in 10 subjects of skin types I and II using a skin-chamber technique and a specific TGF-alpha radioimmunoassay. Significantly elevated concentrations of immunoreactive TGF-alpha were detected in samples after 24 h in UVB-irradiated compared with unirradiated skin. Samples at earlier time points from UVB- and UVA-exposed skin contained measurable levels of TGF-alpha but these were not significantly elevated above the levels found in samples from unirradiated areas. These results, which suggest that UVB irradiation increases release of TGF-alpha from human skin at 24 h, indicate that TGF-alpha may be implicated in UVB-induced epidermal hyperplasia.",
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    INVIVO STUDIES OF THE ACTION SPECTRUM AND TIME COURSE FOR RELEASE OF TRANSFORMING GROWTH FACTOR-ALPHA BY ULTRAVIOLET-IRRADIATION IN MAN. / MURPHY, GM; Quinn, Daniel; CAMP, RDR; HAWK, JLM; GREAVES, MW.

    In: British Journal of Dermatology, Vol. 125, No. 6, 12.1991, p. 566-568.

    Research output: Contribution to journalArticle

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