Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration: Summation in Age-Related Macular Degeneration

Aoife Hunter; RS Anderson; Tony Redmond; David F. Garway-Heath; Padraig Mulholland

doi:10.1167/tvst.12.11.37

Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration: Summation in Age-Related Macular Degeneration

Aoife Hunter
, RS Anderson
, Tony Redmond
, David F. Garway-Heath
, Padraig Mulholland

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose. To measure achromatic spatial, temporal and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls, under conditions of photopic gaze-contingent perimetry.

Methods. Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco’s area (RA) at 2.5° and 5° eccentricity along the 0º, 90º, 180º, and 270º meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7-190.4 ms) with a Goldmann-III stimulus (GIII, 0.43º) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal (using GIII stimulus) and spatiotemporal summation (using RA stimulus) was estimated using iterative two-phase regression analysis.

Results. Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09 – 0.41] deg²; 5°: 0.32 [0.15 – 0.65 deg²]) compared to healthy controls (2.5°: 0.08 [0.05 – 0.13] deg²; 5°: 0.15 [0.08 – 0.22] deg²) at all test locations (all P<0.05). No significant difference in median (IQR) critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9 – 30.4] ms) and RA-scaled stimuli (22.9 [13.9 – 40.3] ms) compared to healthy controls (GIII, 17.0 [11.3 – 24.0] ms; RA-scaled, 22.4 [14.3 – 33.1] ms) at all test locations (all P > 0.05).

Conclusions. Spatial summation is altered in dry AMD, without commensurate changes in temporal summation.

Translational Relevance. The sensitivity of perimetry to AMD may be improved by utilising stimuli that probe alterations in spatial summation in the disease.

Original language	English
Article number	37
Pages (from-to)	1-17
Number of pages	17
Journal	Translational Vision Science & Technology
Volume	12
Issue number	11
Early online date	29 Nov 2023
DOIs	https://doi.org/10.1167/tvst.12.11.37
Publication status	Published online - 29 Nov 2023

Bibliographical note

Funding Information:
Supported by a PhD studentship from the Macular Society, United Kingdom (AMLH) and by the National Institute for Health Research Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology (RSA, DFG-H, PJM). DFG-H’s chair at University College London is supported by funding from Glaucoma UK. The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health. Conference presentation of this work at the 24th International Visual Field & Imaging Symposium (August 2022; Berkeley, CA) was supported by the Imaging and Perimetry Society in the form of a travel grant (AMLH).

Publisher Copyright:
© 2023 The Authors.

Funding

Funding Information: Supported by a PhD studentship from the Macular Society, United Kingdom (AMLH) and by the National Institute for Health Research Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology (RSA, DFG-H, PJM). DFG-H’s chair at University College London is supported by funding from Glaucoma UK. The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health. Conference presentation of this work at the 24th International Visual Field & Imaging Symposium (August 2022; Berkeley, CA) was supported by the Imaging and Perimetry Society in the form of a travel grant (AMLH). Publisher Copyright: © 2023 The Authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Spatial summation
Temporal summation
Age-related macular degeneration
Microperimetry
Perimetry
Ricco's area
ricco’s area
spatial summation
temporal summation
microperimetry
age-related macular degeneration
perimetry

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10.1167/tvst.12.11.37Licence: CC BY-NC-ND

i2164-2591-12-11-37_1701253531.42251Final published version, 1.72 MBLicence: CC BY-NC-ND

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Hunter, A., Anderson, RS., Redmond, T., Garway-Heath, D. F., & Mulholland, P. (2023). Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration: Summation in Age-Related Macular Degeneration . Translational Vision Science & Technology, 12(11), 1-17. Article 37. Advance online publication. https://doi.org/10.1167/tvst.12.11.37

@article{b47300c2245b4c1297eec566c21aa928,

title = "Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration: Summation in Age-Related Macular Degeneration ",

abstract = "Purpose. To measure achromatic spatial, temporal and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls, under conditions of photopic gaze-contingent perimetry. Methods. Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco{\textquoteright}s area (RA) at 2.5° and 5° eccentricity along the 0º, 90º, 180º, and 270º meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7-190.4 ms) with a Goldmann-III stimulus (GIII, 0.43º) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal (using GIII stimulus) and spatiotemporal summation (using RA stimulus) was estimated using iterative two-phase regression analysis. Results. Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09 – 0.41] deg2; 5°: 0.32 [0.15 – 0.65 deg2]) compared to healthy controls (2.5°: 0.08 [0.05 – 0.13] deg2; 5°: 0.15 [0.08 – 0.22] deg2) at all test locations (all P<0.05). No significant difference in median (IQR) critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9 – 30.4] ms) and RA-scaled stimuli (22.9 [13.9 – 40.3] ms) compared to healthy controls (GIII, 17.0 [11.3 – 24.0] ms; RA-scaled, 22.4 [14.3 – 33.1] ms) at all test locations (all P > 0.05). Conclusions. Spatial summation is altered in dry AMD, without commensurate changes in temporal summation. Translational Relevance. The sensitivity of perimetry to AMD may be improved by utilising stimuli that probe alterations in spatial summation in the disease. ",

keywords = "Spatial summation, Temporal summation, Age-related macular degeneration, Microperimetry, Perimetry, Ricco's area, ricco{\textquoteright}s area, spatial summation, temporal summation, microperimetry, age-related macular degeneration, perimetry",

author = "Aoife Hunter and RS Anderson and Tony Redmond and Garway-Heath, \{David F.\} and Padraig Mulholland",

note = "Funding Information: Supported by a PhD studentship from the Macular Society, United Kingdom (AMLH) and by the National Institute for Health Research Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology (RSA, DFG-H, PJM). DFG-H{\textquoteright}s chair at University College London is supported by funding from Glaucoma UK. The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health. Conference presentation of this work at the 24th International Visual Field \& Imaging Symposium (August 2022; Berkeley, CA) was supported by the Imaging and Perimetry Society in the form of a travel grant (AMLH). Publisher Copyright: {\textcopyright} 2023 The Authors.",

year = "2023",

month = nov,

day = "29",

doi = "10.1167/tvst.12.11.37",

language = "English",

volume = "12",

pages = "1--17",

journal = "Translational Vision Science \& Technology",

publisher = "Association for Research in Vision and Ophthalmology",

number = "11",

}

TY - JOUR

T1 - Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration

T2 - Summation in Age-Related Macular Degeneration

AU - Hunter, Aoife

AU - Anderson, RS

AU - Redmond, Tony

AU - Garway-Heath, David F.

AU - Mulholland, Padraig

N1 - Funding Information: Supported by a PhD studentship from the Macular Society, United Kingdom (AMLH) and by the National Institute for Health Research Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology (RSA, DFG-H, PJM). DFG-H’s chair at University College London is supported by funding from Glaucoma UK. The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research, or the Department of Health. Conference presentation of this work at the 24th International Visual Field & Imaging Symposium (August 2022; Berkeley, CA) was supported by the Imaging and Perimetry Society in the form of a travel grant (AMLH). Publisher Copyright: © 2023 The Authors.

PY - 2023/11/29

Y1 - 2023/11/29

N2 - Purpose. To measure achromatic spatial, temporal and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls, under conditions of photopic gaze-contingent perimetry. Methods. Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco’s area (RA) at 2.5° and 5° eccentricity along the 0º, 90º, 180º, and 270º meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7-190.4 ms) with a Goldmann-III stimulus (GIII, 0.43º) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal (using GIII stimulus) and spatiotemporal summation (using RA stimulus) was estimated using iterative two-phase regression analysis. Results. Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09 – 0.41] deg2; 5°: 0.32 [0.15 – 0.65 deg2]) compared to healthy controls (2.5°: 0.08 [0.05 – 0.13] deg2; 5°: 0.15 [0.08 – 0.22] deg2) at all test locations (all P<0.05). No significant difference in median (IQR) critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9 – 30.4] ms) and RA-scaled stimuli (22.9 [13.9 – 40.3] ms) compared to healthy controls (GIII, 17.0 [11.3 – 24.0] ms; RA-scaled, 22.4 [14.3 – 33.1] ms) at all test locations (all P > 0.05). Conclusions. Spatial summation is altered in dry AMD, without commensurate changes in temporal summation. Translational Relevance. The sensitivity of perimetry to AMD may be improved by utilising stimuli that probe alterations in spatial summation in the disease.

AB - Purpose. To measure achromatic spatial, temporal and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls, under conditions of photopic gaze-contingent perimetry. Methods. Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco’s area (RA) at 2.5° and 5° eccentricity along the 0º, 90º, 180º, and 270º meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7-190.4 ms) with a Goldmann-III stimulus (GIII, 0.43º) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal (using GIII stimulus) and spatiotemporal summation (using RA stimulus) was estimated using iterative two-phase regression analysis. Results. Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09 – 0.41] deg2; 5°: 0.32 [0.15 – 0.65 deg2]) compared to healthy controls (2.5°: 0.08 [0.05 – 0.13] deg2; 5°: 0.15 [0.08 – 0.22] deg2) at all test locations (all P<0.05). No significant difference in median (IQR) critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9 – 30.4] ms) and RA-scaled stimuli (22.9 [13.9 – 40.3] ms) compared to healthy controls (GIII, 17.0 [11.3 – 24.0] ms; RA-scaled, 22.4 [14.3 – 33.1] ms) at all test locations (all P > 0.05). Conclusions. Spatial summation is altered in dry AMD, without commensurate changes in temporal summation. Translational Relevance. The sensitivity of perimetry to AMD may be improved by utilising stimuli that probe alterations in spatial summation in the disease.

KW - Spatial summation

KW - Temporal summation

KW - Age-related macular degeneration

KW - Microperimetry

KW - Perimetry

KW - Ricco's area

KW - ricco’s area

KW - spatial summation

KW - temporal summation

KW - microperimetry

KW - age-related macular degeneration

KW - perimetry

UR - https://www.scopus.com/pages/publications/85178493589

U2 - 10.1167/tvst.12.11.37

DO - 10.1167/tvst.12.11.37

M3 - Article

C2 - 38019498

VL - 12

SP - 1

EP - 17

JO - Translational Vision Science & Technology

JF - Translational Vision Science & Technology

IS - 11

M1 - 37

ER -

Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration: Summation in Age-Related Macular Degeneration

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

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