Intravital Ca2+ imaging of pancreatic β cell function after bariatric surgery

Philip Tröster, Per-Olof Berggren

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    Abstract

    Bariatric surgery has long become an appropriate and common treatment for patients with severe obesity and many related conditions such as type 2 diabetes. However, the exact mechanism leading to improved metabolism shortly after surgery, most notably independent of weight loss, has not yet been fully elucidated. Akalestou's recent publication, "Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice," provides the first detailed insight into the progression of pancreatic islet function after bariatric surgery. By transplanting pancreatic islets equipped with a genetically encoded calcium indicator into the anterior chamber of the eye, improvements in Ca2+ dynamics and a more potent β cell network were observed over an extended time course after the surgical procedure. In the following sections, we will take the opportunity to briefly outline the association between bariatric surgery and diabetes, highlight the issue of anesthesia during intravital Ca2+ imaging, and finally comment on some biological relationships related to β cell function.

    Original languageEnglish
    Article number102566
    Number of pages4
    JournalCell Calcium
    Volume104
    Early online date4 Mar 2022
    DOIs
    Publication statusE-pub ahead of print - 4 Mar 2022

    Bibliographical note

    Funding Information:
    Familjen Erling-Perssons Stiftelse, Stichting af Jochnick Foundation, Diabetesfonden, European Research Council (ERC) ?Advanced Grant? (EYELETS), SSF Stiftelsen f?r Strategisk Forskning (Rambidrag MED-X 2018), KI Fonder, Vetenskapsr?det (The Swedisch Research Council), Berth von Kantzows Stiftelse, Novo Nordisk Foundation.

    Publisher Copyright:
    © 2022

    Keywords

    • Bariatric surgery
    • Calcium imaging
    • Diabetes mellitus
    • Intravital microscopy
    • Isoflurane anesthesia
    • Pancreatic β cells

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