Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus

SW Choi, IFF Benzie, CSY Lam, SWS Chat, J Lam, CH Yiu, JJ Kwan, YH Tang, GSP Yeung, VTF Yeung, GC Woo, BM Hannigan, JJ Strain

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Abstract

Aims The onset of complications in Type 2 diabetes mellitus (DM) patients cannot be predicted in individuals. Evidence suggests a link between complications and hyperglycaemia, oxidative stress and antioxidants, but causality is unclear. This study investigated baseline (entry) fasting plasma ascorbic acid, lymphocytic DNA damage and glycaemic control in Type 2 DM as part of a long-term study, the aim of which is to explore a biomarker profiling approach to identify and improve outcome in high-risk subjects. Methods A cross-sectional study, in which DNA damage, glycated haemoglobin (HbA(1c)), fasting plasma glucose (FPG) and ascorbic acid (AA) were measured on fasting blood samples collected from 427 Type 2 DM subjects. Results DNA damage was significantly (P < 0.0001) and directly correlated to both FPG (r = 0.540) and HbA(1c) (r = 0.282), and was significantly (P < 0.0001), independently and inversely correlated to plasma AA (r = -0.449). In those subjects with both poor glycaemic control and low AA (< 48 mu M, the overall mean value for the study group), DNA damage was significantly (P < 0.005) higher compared with those subjects with a similar degree of hyperglycaemia but with AA above the mean. Conclusions The novel finding of a significant inverse relationship between plasma AA and DNA damage in Type 2 DM indicates that poorly controlled diabetic subjects might benefit from increased dietary vitamin C. The data also have important implications for biomarker profiling to identify those subjects who might benefit most from intensive therapy. Longer-term follow-up is underway.
LanguageEnglish
Pages1347-1353
JournalDiabetic medicine
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2005

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Type 2 Diabetes Mellitus
Ascorbic Acid
DNA Damage
Fasting
Hyperglycemia
Biomarkers
Glucose
Glycosylated Hemoglobin A
Causality
Oxidative Stress
Cross-Sectional Studies
Antioxidants

Cite this

Choi, SW ; Benzie, IFF ; Lam, CSY ; Chat, SWS ; Lam, J ; Yiu, CH ; Kwan, JJ ; Tang, YH ; Yeung, GSP ; Yeung, VTF ; Woo, GC ; Hannigan, BM ; Strain, JJ. / Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus. In: Diabetic medicine. 2005 ; Vol. 22, No. 10. pp. 1347-1353.
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abstract = "Aims The onset of complications in Type 2 diabetes mellitus (DM) patients cannot be predicted in individuals. Evidence suggests a link between complications and hyperglycaemia, oxidative stress and antioxidants, but causality is unclear. This study investigated baseline (entry) fasting plasma ascorbic acid, lymphocytic DNA damage and glycaemic control in Type 2 DM as part of a long-term study, the aim of which is to explore a biomarker profiling approach to identify and improve outcome in high-risk subjects. Methods A cross-sectional study, in which DNA damage, glycated haemoglobin (HbA(1c)), fasting plasma glucose (FPG) and ascorbic acid (AA) were measured on fasting blood samples collected from 427 Type 2 DM subjects. Results DNA damage was significantly (P < 0.0001) and directly correlated to both FPG (r = 0.540) and HbA(1c) (r = 0.282), and was significantly (P < 0.0001), independently and inversely correlated to plasma AA (r = -0.449). In those subjects with both poor glycaemic control and low AA (< 48 mu M, the overall mean value for the study group), DNA damage was significantly (P < 0.005) higher compared with those subjects with a similar degree of hyperglycaemia but with AA above the mean. Conclusions The novel finding of a significant inverse relationship between plasma AA and DNA damage in Type 2 DM indicates that poorly controlled diabetic subjects might benefit from increased dietary vitamin C. The data also have important implications for biomarker profiling to identify those subjects who might benefit most from intensive therapy. Longer-term follow-up is underway.",
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Choi, SW, Benzie, IFF, Lam, CSY, Chat, SWS, Lam, J, Yiu, CH, Kwan, JJ, Tang, YH, Yeung, GSP, Yeung, VTF, Woo, GC, Hannigan, BM & Strain, JJ 2005, 'Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus', Diabetic medicine, vol. 22, no. 10, pp. 1347-1353. https://doi.org/10.1111/j.1464-5491.2005.01647.x

Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus. / Choi, SW; Benzie, IFF; Lam, CSY; Chat, SWS; Lam, J; Yiu, CH; Kwan, JJ; Tang, YH; Yeung, GSP; Yeung, VTF; Woo, GC; Hannigan, BM; Strain, JJ.

In: Diabetic medicine, Vol. 22, No. 10, 10.2005, p. 1347-1353.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus

AU - Choi, SW

AU - Benzie, IFF

AU - Lam, CSY

AU - Chat, SWS

AU - Lam, J

AU - Yiu, CH

AU - Kwan, JJ

AU - Tang, YH

AU - Yeung, GSP

AU - Yeung, VTF

AU - Woo, GC

AU - Hannigan, BM

AU - Strain, JJ

PY - 2005/10

Y1 - 2005/10

N2 - Aims The onset of complications in Type 2 diabetes mellitus (DM) patients cannot be predicted in individuals. Evidence suggests a link between complications and hyperglycaemia, oxidative stress and antioxidants, but causality is unclear. This study investigated baseline (entry) fasting plasma ascorbic acid, lymphocytic DNA damage and glycaemic control in Type 2 DM as part of a long-term study, the aim of which is to explore a biomarker profiling approach to identify and improve outcome in high-risk subjects. Methods A cross-sectional study, in which DNA damage, glycated haemoglobin (HbA(1c)), fasting plasma glucose (FPG) and ascorbic acid (AA) were measured on fasting blood samples collected from 427 Type 2 DM subjects. Results DNA damage was significantly (P < 0.0001) and directly correlated to both FPG (r = 0.540) and HbA(1c) (r = 0.282), and was significantly (P < 0.0001), independently and inversely correlated to plasma AA (r = -0.449). In those subjects with both poor glycaemic control and low AA (< 48 mu M, the overall mean value for the study group), DNA damage was significantly (P < 0.005) higher compared with those subjects with a similar degree of hyperglycaemia but with AA above the mean. Conclusions The novel finding of a significant inverse relationship between plasma AA and DNA damage in Type 2 DM indicates that poorly controlled diabetic subjects might benefit from increased dietary vitamin C. The data also have important implications for biomarker profiling to identify those subjects who might benefit most from intensive therapy. Longer-term follow-up is underway.

AB - Aims The onset of complications in Type 2 diabetes mellitus (DM) patients cannot be predicted in individuals. Evidence suggests a link between complications and hyperglycaemia, oxidative stress and antioxidants, but causality is unclear. This study investigated baseline (entry) fasting plasma ascorbic acid, lymphocytic DNA damage and glycaemic control in Type 2 DM as part of a long-term study, the aim of which is to explore a biomarker profiling approach to identify and improve outcome in high-risk subjects. Methods A cross-sectional study, in which DNA damage, glycated haemoglobin (HbA(1c)), fasting plasma glucose (FPG) and ascorbic acid (AA) were measured on fasting blood samples collected from 427 Type 2 DM subjects. Results DNA damage was significantly (P < 0.0001) and directly correlated to both FPG (r = 0.540) and HbA(1c) (r = 0.282), and was significantly (P < 0.0001), independently and inversely correlated to plasma AA (r = -0.449). In those subjects with both poor glycaemic control and low AA (< 48 mu M, the overall mean value for the study group), DNA damage was significantly (P < 0.005) higher compared with those subjects with a similar degree of hyperglycaemia but with AA above the mean. Conclusions The novel finding of a significant inverse relationship between plasma AA and DNA damage in Type 2 DM indicates that poorly controlled diabetic subjects might benefit from increased dietary vitamin C. The data also have important implications for biomarker profiling to identify those subjects who might benefit most from intensive therapy. Longer-term follow-up is underway.

U2 - 10.1111/j.1464-5491.2005.01647.x

DO - 10.1111/j.1464-5491.2005.01647.x

M3 - Article

VL - 22

SP - 1347

EP - 1353

JO - Diabetes Medicine

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JF - Diabetes Medicine

SN - 0742-3071

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