Integration of Riboflavin-Modified Carbon Fiber Mesh Electrode Systems in a 3D-Printed Catheter Hub

Charnete Casimero, Robert B. Smith, James Davis

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Abstract

Background: Catheter line infection is a common complication within clinical environments, and there is a pressing need for technological options to aid in reducing the possibility of sepsis. The early identification of contamination could be pivotal in reducing cases and improving outcomes. Method: A sensing rationale based on a riboflavin-modified electrode system integrated within a modified 3D-printed catheter needle-free connector is proposed, which can monitor changes in pH brought about by bacterial contamination. Results: Riboflavin, vitamin B2, is a biocompatible chemical that possesses a redox-active flavin core that is pH dependent. The oxidation peak potential of the adsorbed riboflavin responds linearly to changes in pH with a near-Nernstian behavior of 63 mV/pH unit and is capable of accurately monitoring the pH of an authentic IV infusate. Conclusions: The proof of principle is demonstrated with an electrode-printed hub design offering a valuable foundation from which to explore bacterial interactions within the catheter lumen with the potential of providing an early warning of contamination.
Original languageEnglish
Article number79
Pages (from-to)1-13
Number of pages13
JournalMicromachines
Volume15
Issue number1
Early online date30 Dec 2023
DOIs
Publication statusPublished online - 30 Dec 2023

Keywords

  • catheter
  • CLABSI
  • infection
  • sensor
  • screen-printed electrode
  • SPE
  • riboflavin
  • total parenteral nutrition
  • TPN

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