Integrated urate sensors for detecting wound infection

D Sharp, J Davis

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    The applicability of employing a carbon fibre mesh as the sensing element within a "smart bandage" for assessing urate transformations within wound exudates is evaluated and a novel strategy for the detection of bacterial contamination presented. Prototype sensor assemblies have been designed and their response characteristics towards the periodic monitoring of uric acid within whole blood, serum, blister fluid and microbial culture has been evaluated. The rapid and selective metabolism of urate by Pseudomonas aeruginosa, the bacteria responsible for most adventitious wound infections, has been investigated. A preliminary evaluation of the efficacy of utilizing the microbial response to endogenous wound urate as means of detecting the onset of infection is presented.
    Original languageEnglish
    Pages (from-to)709-713
    JournalElectrochemistry Communications
    Volume10
    Issue number5
    DOIs
    Publication statusPublished - May 2008

    Keywords

    • carbon fibre
    • smart bandage
    • urate
    • bacteria
    • wound
    • microbial
    • Pseudomonas aeruginosa

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