Integrated urate sensors for detecting wound infection

D Sharp, J Davis

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    The applicability of employing a carbon fibre mesh as the sensing element within a "smart bandage" for assessing urate transformations within wound exudates is evaluated and a novel strategy for the detection of bacterial contamination presented. Prototype sensor assemblies have been designed and their response characteristics towards the periodic monitoring of uric acid within whole blood, serum, blister fluid and microbial culture has been evaluated. The rapid and selective metabolism of urate by Pseudomonas aeruginosa, the bacteria responsible for most adventitious wound infections, has been investigated. A preliminary evaluation of the efficacy of utilizing the microbial response to endogenous wound urate as means of detecting the onset of infection is presented.
    LanguageEnglish
    Pages709-713
    JournalElectrochemistry Communications
    Volume10
    Issue number5
    DOIs
    Publication statusPublished - May 2008

    Fingerprint

    Uric Acid
    Metabolism
    Carbon fibers
    Bacteria
    Contamination
    Blood
    Fluids
    Acids
    Monitoring
    Sensors

    Keywords

    • carbon fibre
    • smart bandage
    • urate
    • bacteria
    • wound
    • microbial
    • Pseudomonas aeruginosa

    Cite this

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    abstract = "The applicability of employing a carbon fibre mesh as the sensing element within a {"}smart bandage{"} for assessing urate transformations within wound exudates is evaluated and a novel strategy for the detection of bacterial contamination presented. Prototype sensor assemblies have been designed and their response characteristics towards the periodic monitoring of uric acid within whole blood, serum, blister fluid and microbial culture has been evaluated. The rapid and selective metabolism of urate by Pseudomonas aeruginosa, the bacteria responsible for most adventitious wound infections, has been investigated. A preliminary evaluation of the efficacy of utilizing the microbial response to endogenous wound urate as means of detecting the onset of infection is presented.",
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    Integrated urate sensors for detecting wound infection. / Sharp, D; Davis, J.

    In: Electrochemistry Communications, Vol. 10, No. 5, 05.2008, p. 709-713.

    Research output: Contribution to journalArticle

    TY - JOUR

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    AU - Sharp, D

    AU - Davis, J

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    AB - The applicability of employing a carbon fibre mesh as the sensing element within a "smart bandage" for assessing urate transformations within wound exudates is evaluated and a novel strategy for the detection of bacterial contamination presented. Prototype sensor assemblies have been designed and their response characteristics towards the periodic monitoring of uric acid within whole blood, serum, blister fluid and microbial culture has been evaluated. The rapid and selective metabolism of urate by Pseudomonas aeruginosa, the bacteria responsible for most adventitious wound infections, has been investigated. A preliminary evaluation of the efficacy of utilizing the microbial response to endogenous wound urate as means of detecting the onset of infection is presented.

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    KW - smart bandage

    KW - urate

    KW - bacteria

    KW - wound

    KW - microbial

    KW - Pseudomonas aeruginosa

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    DO - 10.1016/j.elecom.2008.02.025

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    JF - Electrochemistry Communications

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