Integrated space–frequency–time domain feature extraction for MEG-based Alzheimer’s disease classification

Scott Yang, Jose Sanchez Bornot, Ricardo Fernandez, Farzin Deravi, KongFatt Wong-Lin, Girijesh Prasad

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
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Magnetoencephalography (MEG) has been combined with machine learning techniques, to recognize the Alzheimer’s disease (AD), one of the most common forms of dementia. However, most of the previous studies are limited to binary classification and do not fully utilize the two available MEG modalities (extracted using magnetometer and gradiometer sensors). AD consists of several stages of progression, this study addresses this limitation by using both magnetometer and gradiometer data to discriminate between participants with AD, AD-related mild cognitive impairment (MCI), and healthy control (HC) participants in the form of a three-class classification problem. A series of wavelet-based biomarkers are developed and evaluated, which concurrently leverage the spatial, frequency and time domain characteristics of the signal. A bimodal recognition system based on an improved score-level fusion approach is proposed to reinforce interpretation of the brain activity captured by magnetometers and gradiometers. In this preliminary study, it was found that the markers derived from gradiometer tend to outperform the magnetometer-based markers. Interestingly, out of the total 10 regions of interest, left-frontal lobe demonstrates about 8% higher mean recognition rate than the second-best performing region (left temporal lobe) for AD/MCI/HC classification. Among the four types of markers proposed in this work, the spatial marker developed using wavelet coefficients provided the best recognition performance for the three-way classification. Overall, the proposed approach provides promising results for the potential of AD/MCI/HC three-way classification utilizing the bimodal MEG data.
Original languageEnglish
Article number24 (2021)
Pages (from-to)1-11
Number of pages11
JournalBrain Informatics
Early online date2 Nov 2021
Publication statusPublished online - 2 Nov 2021

Bibliographical note

Funding Information:
This work was supported by the Northern Ireland Functional Brain Mapping Project Facility (1303/101154803), funded by Invest Northern Ireland and the University of Ulster, Alzheimer’s Research UK (ARUK) NI Pump Priming, EU’s INTERREG VA Programme, managed by the Special EU Programs Body (SEUPB), Ulster University Research Challenge Fund.

Publisher Copyright:
© 2021, The Author(s).


  • MEG
  • Alzheimer’s disease (AD)
  • wavelet-based biomarkers
  • space–frequency–time domain feature
  • bi-modal
  • Multi-domain
  • Alzheimer’s disease
  • Magnetoencephalography
  • Mild cognitive impairment
  • Biomarkers
  • Spatio-temporal features


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