Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: a structure-activity study

D Srinivasan, Opeolu Ojo, Yasser Abdel-Wahab, Peter Flatt, L Guilhaudis, JM Conlon

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

insulin release and cytotoxicity of changes in cationicity and hydrophobicity produced by selected substitutions of amino acids by l-arginine, l-lysine and l-tryptophan. The [A5W], [L8W] and [I10W] analogs produced a significant (P
LanguageEnglish
Pages23-31
JournalPeptides
Volume55
Publication statusPublished - 12 Feb 2014

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Amino Acid Substitution
Cytotoxicity
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Tryptophan
Anura
Lysine
Arginine
Skin
Substitution reactions
Insulin
Amino Acids
Peptides

Cite this

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Insulin-releasing and cytotoxic properties of the frog skin peptide, tigerinin-1R: a structure-activity study. / Srinivasan, D; Ojo, Opeolu; Abdel-Wahab, Yasser; Flatt, Peter; Guilhaudis, L; Conlon, JM.

Vol. 55, 12.02.2014, p. 23-31.

Research output: Contribution to journalArticle

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AU - Srinivasan, D

AU - Ojo, Opeolu

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AU - Flatt, Peter

AU - Guilhaudis, L

AU - Conlon, JM

PY - 2014/2/12

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