Innovative Applications of Plant Viruses in Drug Targeting and Molecular Imaging- A review

Alaa A A Aljabali, Mazhar S. Al Zoubi, Khalid M. Al-batayneh, Dinesh M. Pardhi, Kamal Dua, Kaushik Pal, Murtaza M. Tambuwala

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
5 Downloads (Pure)


Background: Nature had already engineered various types of nanoparticles (NPs), especially viruses, which can deliver their cargo to the host/targeted cells. The ability to selectively target specific cells offers a significant advantage over the conventional approach. Numerous organic NPs, including native protein cages, virus-like pieces, polymeric saccharides, and liposomes, have been used for the preparation of nanoparticulate. Such nanomaterials have demonstrated better performance and as well as improved biocompatible, devoid of side effects, and stable without any deterioration.

Objective: This review discusses current clinical and scientific research on naturally occurring nanomaterials. The review illustrates and updates the tailor-made approaches for selective delivery and targeted medications that require a high-affinity interconnection to the targeted cells.

Method: A comprehensive search was performed using keywords for viral nanoparticles, viral particles for drug delivery, viral nanoparticles for molecular imaging, theranostics applications of viral nanoparticles and plant viruses in nanomedicine. We searched in Google Scholar, PubMed, Springer, Medline, and Elsevier from 2000 to till date and by the bibliographic review of all identified articles.

Results: The findings demonstrated that structures dependent on nanomaterials might have potential applications in diagnostics, cell marking, comparing agents (computed tomography and magnetic resonance imaging), and antimicrobial drugs, as well as drug delivery structures. However, measures should be taken in order to prevent or mitigate in pharmaceutical or medical applications the toxic impact or incompatibility of nanoparticle-based structures with biological systems.

Conclusion: The review provided an overview of the latest advances in nanotechnology, outlining the difficulties and the advantages of in vivo and in vitro structures that are focused on a specific subset of the natural nanomaterials.
Original languageEnglish
Pages (from-to)491-506
Number of pages16
JournalCurrent Medical Imaging Formerly Current Medical Imaging Reviews
Issue number4
Publication statusPublished (in print/issue) - 7 Oct 2020


  • Radiology Nuclear Medicine and imaging


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