INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES

E CLARKE, Daniel Quinn, SR MCCANN

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Cyclosporin A is used to prevent graft-versus-host disease (GvHD) following bone marrow transplantation (BMT) and it has been implicated in reducing the time to engraftment for leukaemia and aplastic anaemia patients. To evaluate the effect of cyclosporin A on engraftment, the proliferative capacity of bone marrow progenitors (CFU-E, CFU-F and CFU-C) was assessed both in vitro and following treatment with cyclosporin A over a 9-week period using an animal model. Cyclosporin had a differential effect on the haemopoietic progenitors, with the myeloid series unaffected at therapeutic concentrations. Both erythroid and stromal progenitors were significantly inhibited at similar concentrations. The mechanism by which cyclosporin A enhances engraftment remains unclear; however, it is not mediated by enhancing any of the haemopoietic progenitors.
    LanguageEnglish
    Pages282-286
    JournalEuropean Journal of Haematology
    Volume47
    Issue number4
    Publication statusPublished - Oct 1991

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    Cyclosporine
    Erythroid Precursor Cells
    Aplastic Anemia
    Graft vs Host Disease
    Bone Marrow Transplantation
    Leukemia
    Animal Models
    Bone Marrow
    Therapeutics

    Cite this

    CLARKE, E ; Quinn, Daniel ; MCCANN, SR. / INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES. In: European Journal of Haematology. 1991 ; Vol. 47, No. 4. pp. 282-286.
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    abstract = "Cyclosporin A is used to prevent graft-versus-host disease (GvHD) following bone marrow transplantation (BMT) and it has been implicated in reducing the time to engraftment for leukaemia and aplastic anaemia patients. To evaluate the effect of cyclosporin A on engraftment, the proliferative capacity of bone marrow progenitors (CFU-E, CFU-F and CFU-C) was assessed both in vitro and following treatment with cyclosporin A over a 9-week period using an animal model. Cyclosporin had a differential effect on the haemopoietic progenitors, with the myeloid series unaffected at therapeutic concentrations. Both erythroid and stromal progenitors were significantly inhibited at similar concentrations. The mechanism by which cyclosporin A enhances engraftment remains unclear; however, it is not mediated by enhancing any of the haemopoietic progenitors.",
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    CLARKE, E, Quinn, D & MCCANN, SR 1991, 'INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES', European Journal of Haematology, vol. 47, no. 4, pp. 282-286.

    INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES. / CLARKE, E; Quinn, Daniel; MCCANN, SR.

    In: European Journal of Haematology, Vol. 47, No. 4, 10.1991, p. 282-286.

    Research output: Contribution to journalArticle

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    AB - Cyclosporin A is used to prevent graft-versus-host disease (GvHD) following bone marrow transplantation (BMT) and it has been implicated in reducing the time to engraftment for leukaemia and aplastic anaemia patients. To evaluate the effect of cyclosporin A on engraftment, the proliferative capacity of bone marrow progenitors (CFU-E, CFU-F and CFU-C) was assessed both in vitro and following treatment with cyclosporin A over a 9-week period using an animal model. Cyclosporin had a differential effect on the haemopoietic progenitors, with the myeloid series unaffected at therapeutic concentrations. Both erythroid and stromal progenitors were significantly inhibited at similar concentrations. The mechanism by which cyclosporin A enhances engraftment remains unclear; however, it is not mediated by enhancing any of the haemopoietic progenitors.

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