INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES

E CLARKE, Daniel Quinn, SR MCCANN

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Cyclosporin A is used to prevent graft-versus-host disease (GvHD) following bone marrow transplantation (BMT) and it has been implicated in reducing the time to engraftment for leukaemia and aplastic anaemia patients. To evaluate the effect of cyclosporin A on engraftment, the proliferative capacity of bone marrow progenitors (CFU-E, CFU-F and CFU-C) was assessed both in vitro and following treatment with cyclosporin A over a 9-week period using an animal model. Cyclosporin had a differential effect on the haemopoietic progenitors, with the myeloid series unaffected at therapeutic concentrations. Both erythroid and stromal progenitors were significantly inhibited at similar concentrations. The mechanism by which cyclosporin A enhances engraftment remains unclear; however, it is not mediated by enhancing any of the haemopoietic progenitors.
    Original languageEnglish
    Pages (from-to)282-286
    JournalEuropean Journal of Haematology
    Volume47
    Issue number4
    Publication statusPublished - Oct 1991

    Fingerprint Dive into the research topics of 'INHIBITORY EFFECT OF CYCLOSPORINE-A ON ERYTHROID AND STROMAL COLONIES'. Together they form a unique fingerprint.

  • Cite this