The present book includes extended and revised versions of a set of selected papers from the International Conference on Information and Communication Technologies for Ageing Well and e-Health (ICT4AWE 2021 and 2022), which were exceptionally held as online events, due to COVID-19. ICT4AWE 2021 received 33 paper submissions from 23 countries, of which 15% were included in this book. ICT4AWE 2022 received 50 paper submissions from 24 countries, of which 32% were included in this book. The papers were selected by the event chairs and their selection is based on a number of quality criteria that include the classifications and comments provided by the program committee members, the session chairs’ assessment and also the program chairs’ general assessment of all papers included in the technical program. The authors of selected papers were then invited to submit a revised and extended version of their papers having at least 30% innovative material. The International Conference on Information and Communication Technologies for Ageing Well and e-Health fosters close exchange and collaboration in the field of digital assistive technologies in the health care domain. The conference aims to be a meeting point for those that study age and health-related quality of life and apply information and communication technologies to help people stay healthier, more independent and active at work or in their community. ICT4AWE facilitates the exchange of information and dissemination of best practices, innovation and technical improvements in the fields of age and health care, education, psychology, social coordination and ambient assisted living. From e-Health to intelligent systems and ICT devices, the conference is a vibrant discussion and collaboration platform for all those that work in research and development or in companies involved in promoting the quality of life and well-being of people, by providing room for research and industrial presentations, demos and project descriptions. The papers selected to be included in this book contribute to the understanding of relevant trends of current research on Information and Communication Technologies for Ageing Well and e-Health, including: Decision Support Systems, Home Care Monitoring Systems, Systems to Encourage Healthy Lifestyles, Diagnostic Support, Acceptance of Ambient Technology, Internet of Things and Smart Devices for Independent Living, Mobile Health Monitoring, Psychological Dimension of Aging Population, Privacy and Ethical Issues, Open Data and Health Information, Inclusive Design, Human Communication and Behavioural Studies of Senior Citizens, Health Information Systems, Game-Based Approaches towards Health Awareness, Electronic Health Records, Case Studies in eHealth and Autonomy and Active Ageing. We would like to thank all the authors for their contributions and also the reviewers who have helped to ensure the quality of this publication.