Abstract
BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p
| Original language | English |
|---|---|
| Pages (from-to) | 749-758 |
| Journal | Biochimica et Biophysica Acta (BBA) - General Subjects |
| Volume | 1861 |
| Issue number | 4 |
| Early online date | 7 Jan 2017 |
| DOIs | |
| Publication status | Published online - 7 Jan 2017 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Beta-cell
- Islets
- Neuropeptide Y
- Pancreatic polypeptide
- NPYR
- Insulin secretion
- Proliferation
- Apoptosis
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