Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival

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Abstract

BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p
Original languageEnglish
Pages (from-to)749-758
JournalBiochimica et Biophysica Acta (BBA) - General Subjects
Volume1861
Issue number4
Early online date7 Jan 2017
DOIs
Publication statusE-pub ahead of print - 7 Jan 2017

Keywords

  • Beta-cell
  • Islets
  • Neuropeptide Y
  • Pancreatic polypeptide
  • NPYR
  • Insulin secretion
  • Proliferation
  • Apoptosis

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