Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival

Dawood Khan; Srividya Vasu; Charlotte Moffett; Nigel Irwin; Peter Flatt

doi:10.1016/j.bbagen.2017.01.005

Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival

Dawood Khan, Srividya Vasu, Charlotte Moffett, Nigel Irwin, Peter Flatt

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

74 Downloads (Pure)

Abstract

BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p

Original language	English
Pages (from-to)	749-758
Journal	Biochimica et Biophysica Acta (BBA) - General Subjects
Volume	1861
Issue number	4
Early online date	7 Jan 2017
DOIs	https://doi.org/10.1016/j.bbagen.2017.01.005
Publication status	Published online - 7 Jan 2017

Keywords

Beta-cell
Islets
Neuropeptide Y
Pancreatic polypeptide
NPYR
Insulin secretion
Proliferation
Apoptosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bbagen.2017.01.005

BBA Text revised CLEANAuthor Accepted Manuscript, 1.29 MB

Cite this

@article{21cf69991d6045a69b909687dfcfd1f5,

title = "Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival",

abstract = "BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p",

keywords = "Beta-cell, Islets, Neuropeptide Y, Pancreatic polypeptide, NPYR, Insulin secretion, Proliferation, Apoptosis",

author = "Dawood Khan and Srividya Vasu and Charlotte Moffett and Nigel Irwin and Peter Flatt",

year = "2017",

month = jan,

day = "7",

doi = "10.1016/j.bbagen.2017.01.005",

language = "English",

volume = "1861",

pages = "749--758",

journal = "Biochimica et Biophysica Acta (BBA) - General Subjects",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival

AU - Khan, Dawood

AU - Vasu, Srividya

AU - Moffett, Charlotte

AU - Irwin, Nigel

AU - Flatt, Peter

PY - 2017/1/7

Y1 - 2017/1/7

N2 - BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p

AB - BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p

KW - Beta-cell

KW - Islets

KW - Neuropeptide Y

KW - Pancreatic polypeptide

KW - NPYR

KW - Insulin secretion

KW - Proliferation

KW - Apoptosis

UR - https://pure.ulster.ac.uk/en/publications/influence-of-neuropeptide-y-and-pancreatic-polypeptide-on-islet-f-3

U2 - 10.1016/j.bbagen.2017.01.005

DO - 10.1016/j.bbagen.2017.01.005

M3 - Article

C2 - 28069397

VL - 1861

SP - 749

EP - 758

JO - Biochimica et Biophysica Acta (BBA) - General Subjects

JF - Biochimica et Biophysica Acta (BBA) - General Subjects

IS - 4

ER -

Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this