Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p
LanguageEnglish
Pages749-758
JournalBiochimica et Biophysica Acta (BBA) - General Subjects
Volume1861
Issue number4
Early online date7 Jan 2017
DOIs
Publication statusE-pub ahead of print - 7 Jan 2017

Fingerprint

Pancreatic Polypeptide
Neuropeptide Y
Cell Survival
Neuropeptide Y Receptors
Peptides
Streptozocin
Islets of Langerhans
Hydrocortisone
Cell Proliferation
Insulin
Apoptosis
Glucose

Keywords

  • Beta-cell
  • Islets
  • Neuropeptide Y
  • Pancreatic polypeptide
  • NPYR
  • Insulin secretion
  • Proliferation
  • Apoptosis

Cite this

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abstract = "BACKGROUND: In the present study we assessed the impact of neuropeptide Y receptor (NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet function and beta-cell survival.METHODS: The effects of NPY and PP on beta-cell function were examined in BRIN BD11 and 1.1B4 beta-cells, as well as isolated mouse islets. Involvement of both peptides in pancreatic islet adaptations to streptozotocin and hydrocortisone, as well as effects on beta-cell proliferation and apoptosis was also evaluated.RESULTS: Neither NPY nor PP affected in vivo glucose disposal or insulin secretion in mice. However, both peptides inhibited (p",
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Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. / Khan, Dawood; Vasu, Srividya; Moffett, Charlotte; Irwin, Nigel; Flatt, Peter.

Vol. 1861, No. 4, 07.01.2017, p. 749-758.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Khan, Dawood

AU - Vasu, Srividya

AU - Moffett, Charlotte

AU - Irwin, Nigel

AU - Flatt, Peter

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