Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide

Neville McClenaghan, AJ Ball, Peter Flatt

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

1 Acute and chronic mechanisms of action of novel insulinotropic antidiabetic drug, BTS 67 582 (1,1-dimethyl-2-(2-morpholinophenyl)guanidin fumarate), were examined in the stable cultured BRIN-BD11 cell line. 2 BTS67582 (100-400 mu M) stimulated a concentration-dependent increase (P
Original languageEnglish
Pages (from-to)478-484
JournalBritish Journal of Pharmacology
Volume130
Issue number2
Publication statusPublished - May 2000

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