Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide

Neville McClenaghan; AJ Ball; Peter Flatt

Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide

Neville McClenaghan, AJ Ball, Peter Flatt

Research output: Contribution to journal › Article › peer-review

Abstract

1 Acute and chronic mechanisms of action of novel insulinotropic antidiabetic drug, BTS 67 582 (1,1-dimethyl-2-(2-morpholinophenyl)guanidin fumarate), were examined in the stable cultured BRIN-BD11 cell line. 2 BTS67582 (100-400 mu M) stimulated a concentration-dependent increase (P

Original language	English
Pages (from-to)	478-484
Journal	British Journal of Pharmacology
Volume	130
Issue number	2
Publication status	Published (in print/issue) - May 2000

Cite this

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title = "Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide",

abstract = "1 Acute and chronic mechanisms of action of novel insulinotropic antidiabetic drug, BTS 67 582 (1,1-dimethyl-2-(2-morpholinophenyl)guanidin fumarate), were examined in the stable cultured BRIN-BD11 cell line. 2 BTS67582 (100-400 mu M) stimulated a concentration-dependent increase (P",

author = "Neville McClenaghan and AJ Ball and Peter Flatt",

year = "2000",

month = may,

language = "English",

volume = "130",

pages = "478--484",

journal = "British Journal of Pharmacology",

issn = "1476-5381",

publisher = "John Wiley & Sons, Inc.",

number = "2",

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TY - JOUR

T1 - Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide

AU - McClenaghan, Neville

AU - Ball, AJ

AU - Flatt, Peter

PY - 2000/5

Y1 - 2000/5

N2 - 1 Acute and chronic mechanisms of action of novel insulinotropic antidiabetic drug, BTS 67 582 (1,1-dimethyl-2-(2-morpholinophenyl)guanidin fumarate), were examined in the stable cultured BRIN-BD11 cell line. 2 BTS67582 (100-400 mu M) stimulated a concentration-dependent increase (P

AB - 1 Acute and chronic mechanisms of action of novel insulinotropic antidiabetic drug, BTS 67 582 (1,1-dimethyl-2-(2-morpholinophenyl)guanidin fumarate), were examined in the stable cultured BRIN-BD11 cell line. 2 BTS67582 (100-400 mu M) stimulated a concentration-dependent increase (P

M3 - Article

SN - 1476-5381

VL - 130

SP - 478

EP - 484

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 2

ER -

Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide

Abstract

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