TY - JOUR
T1 - Incremental Cholecalciferol Supplementation up to 15 μg/d Throughout Winter at 51–55° N Has No Effect on Biomarkers of Cardiovascular Risk in Healthy Young and Older Adults
AU - Muldowney, Siobhan
AU - Lucey, Alice J.
AU - Hill, Tom R.
AU - Seamans, Kelly M.
AU - Taylor, Nicola
AU - Wallace, Julie M.W.
AU - Horigan, Geraldine
AU - Barnes, Maria S.
AU - Bonham, Maxine P.
AU - Duffy, Emeir M.
AU - Strain, J. J.
AU - Cashman, Kevin D.
AU - Kiely, Mairead
PY - 2012/6/27
Y1 - 2012/6/27
N2 - Two separate, identical, double-blind, randomized, placebo-controlled intervention studies were carried out in the south and north of Ireland (51-557deg;N). Men and women aged 20-40 y (n = 202) and ≥64 y (n = 192) received cholecalciferol at doses of 0 (P), 5 (D3-5), 10 (D3-10), or 15 (D3-15) μg/d (0-600 IU) during wintertime. Serum 25-hydroxyvitamin D [s25(OH)D], intact parathyroid hormone, systolic and diastolic blood pressure, fasting lipids, glucose and insulin, HOMA-IR, high-sensitivity CRP, matrix metalloproteinase-9, and its inhibitor (tissue inhibitor metalloproteinase-1) were measured at baseline (October) and 22wk later at endpoint (March). Vitamin D receptor Fok I and Taq I genotypes were analyzed and dietary intakes of vitamin D and calcium were assessed. In young adults, s25(OH)D decreased from baseline to endpoint (P < 0.001), except in the D3-15 group, who maintained the baseline concentration of ̃70 nmol/L. Older adults had lower s25(OH)D at baseline (median, 54.2 nmol/L) and concentrations increased in the D3-10 and D3-15 groups (P < 0.001). There were no significant effects of supplementation on cardiovascular disease (CVD) risk biomarkers in either age group. Fasting glucose and total and HDL cholesterolwere lower (P,<0.05) in older adults with the Fok 1 ff genotype than in thosewith FF or Ff. Putative effects of vitamin D on cardio-metabolic health will only be evident at higher intakes than the current RDA and possibly in individuals at particular risk of low s25(OH)D and/or CVD risk.
AB - Two separate, identical, double-blind, randomized, placebo-controlled intervention studies were carried out in the south and north of Ireland (51-557deg;N). Men and women aged 20-40 y (n = 202) and ≥64 y (n = 192) received cholecalciferol at doses of 0 (P), 5 (D3-5), 10 (D3-10), or 15 (D3-15) μg/d (0-600 IU) during wintertime. Serum 25-hydroxyvitamin D [s25(OH)D], intact parathyroid hormone, systolic and diastolic blood pressure, fasting lipids, glucose and insulin, HOMA-IR, high-sensitivity CRP, matrix metalloproteinase-9, and its inhibitor (tissue inhibitor metalloproteinase-1) were measured at baseline (October) and 22wk later at endpoint (March). Vitamin D receptor Fok I and Taq I genotypes were analyzed and dietary intakes of vitamin D and calcium were assessed. In young adults, s25(OH)D decreased from baseline to endpoint (P < 0.001), except in the D3-15 group, who maintained the baseline concentration of ̃70 nmol/L. Older adults had lower s25(OH)D at baseline (median, 54.2 nmol/L) and concentrations increased in the D3-10 and D3-15 groups (P < 0.001). There were no significant effects of supplementation on cardiovascular disease (CVD) risk biomarkers in either age group. Fasting glucose and total and HDL cholesterolwere lower (P,<0.05) in older adults with the Fok 1 ff genotype than in thosewith FF or Ff. Putative effects of vitamin D on cardio-metabolic health will only be evident at higher intakes than the current RDA and possibly in individuals at particular risk of low s25(OH)D and/or CVD risk.
UR - http://www.scopus.com/inward/record.url?scp=84866269480&partnerID=8YFLogxK
U2 - 10.3945/jn.111.154005
DO - 10.3945/jn.111.154005
M3 - Article
C2 - 22739371
AN - SCOPUS:84866269480
SN - 0022-3166
VL - 142
SP - 1519
EP - 1525
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 8
ER -
