Increasing prevalence of gastroschisis in Europe 1980-2002: a phenomenon restricted to younger mothers?

Maria Loane, Helen Dolk, I Bradbury, Working Group EUROCAT

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129 Citations (Scopus)

Abstract

Gastroschisis is an abdominal wall defect more prevalent in offspring of young mothers. It is known to be increasing in prevalence despite the general decrease in the proportion of births to young European women. We investigated whether the increase in prevalence was restricted to the high-risk younger mothers. We analysed 936 cases of gastroschisis from 25 population-based registries in 15 European countries, 1980-2002. We fitted a Bayesian Hierarchical Model which allowed us to estimate trend, to estimate which registries were significantly different from the common distribution, and to adjust simultaneously for maternal age, time (in grouped years) and the random variation between registries.The maternal age-standardised prevalence (standardised to the year 2000 European maternal age structure) increased almost fourfold from 0.54 [95% Credible Interval (CrI) 0.37, 0.75] per 10 000 births in 1980-84 to 2.12 [95% CrI 1.85, 2.40] per 10 000 births in 2000-02. The relative risk of gastroschisis for mothers
Original languageEnglish
Pages (from-to)363-369
JournalPaediatric and Perinatal Epidemiology
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 2007

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