Increasing prevalence of gastroschisis in Europe 1980-2002: a phenomenon restricted to younger mothers?

Maria Loane, Helen Dolk, I Bradbury, Working Group EUROCAT

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Abstract

Gastroschisis is an abdominal wall defect more prevalent in offspring of young mothers. It is known to be increasing in prevalence despite the general decrease in the proportion of births to young European women. We investigated whether the increase in prevalence was restricted to the high-risk younger mothers. We analysed 936 cases of gastroschisis from 25 population-based registries in 15 European countries, 1980-2002. We fitted a Bayesian Hierarchical Model which allowed us to estimate trend, to estimate which registries were significantly different from the common distribution, and to adjust simultaneously for maternal age, time (in grouped years) and the random variation between registries.The maternal age-standardised prevalence (standardised to the year 2000 European maternal age structure) increased almost fourfold from 0.54 [95% Credible Interval (CrI) 0.37, 0.75] per 10 000 births in 1980-84 to 2.12 [95% CrI 1.85, 2.40] per 10 000 births in 2000-02. The relative risk of gastroschisis for mothers
LanguageEnglish
Pages363-369
JournalPaediatric and Perinatal Epidemiology
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 2007

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Gastroschisis
Maternal Age
Registries
Mothers
Parturition
Abdominal Wall
Population

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title = "Increasing prevalence of gastroschisis in Europe 1980-2002: a phenomenon restricted to younger mothers?",
abstract = "Gastroschisis is an abdominal wall defect more prevalent in offspring of young mothers. It is known to be increasing in prevalence despite the general decrease in the proportion of births to young European women. We investigated whether the increase in prevalence was restricted to the high-risk younger mothers. We analysed 936 cases of gastroschisis from 25 population-based registries in 15 European countries, 1980-2002. We fitted a Bayesian Hierarchical Model which allowed us to estimate trend, to estimate which registries were significantly different from the common distribution, and to adjust simultaneously for maternal age, time (in grouped years) and the random variation between registries.The maternal age-standardised prevalence (standardised to the year 2000 European maternal age structure) increased almost fourfold from 0.54 [95{\%} Credible Interval (CrI) 0.37, 0.75] per 10 000 births in 1980-84 to 2.12 [95{\%} CrI 1.85, 2.40] per 10 000 births in 2000-02. The relative risk of gastroschisis for mothers",
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Increasing prevalence of gastroschisis in Europe 1980-2002: a phenomenon restricted to younger mothers? / Loane, Maria; Dolk, Helen; Bradbury, I; EUROCAT, Working Group.

Vol. 21, No. 4, 07.2007, p. 363-369.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increasing prevalence of gastroschisis in Europe 1980-2002: a phenomenon restricted to younger mothers?

AU - Loane, Maria

AU - Dolk, Helen

AU - Bradbury, I

AU - EUROCAT, Working Group

PY - 2007/7

Y1 - 2007/7

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AB - Gastroschisis is an abdominal wall defect more prevalent in offspring of young mothers. It is known to be increasing in prevalence despite the general decrease in the proportion of births to young European women. We investigated whether the increase in prevalence was restricted to the high-risk younger mothers. We analysed 936 cases of gastroschisis from 25 population-based registries in 15 European countries, 1980-2002. We fitted a Bayesian Hierarchical Model which allowed us to estimate trend, to estimate which registries were significantly different from the common distribution, and to adjust simultaneously for maternal age, time (in grouped years) and the random variation between registries.The maternal age-standardised prevalence (standardised to the year 2000 European maternal age structure) increased almost fourfold from 0.54 [95% Credible Interval (CrI) 0.37, 0.75] per 10 000 births in 1980-84 to 2.12 [95% CrI 1.85, 2.40] per 10 000 births in 2000-02. The relative risk of gastroschisis for mothers

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