Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Late potential (LP) analysis in the signal-averaged ECG is a useful clinical tool in the detection of patients at risk after myocardial infarction (Mi). The presence of abnormal LP activity has been correlated with inducible ventricular tachycardia (VT) at programmed electrical stimulation in post-MI patients. A novel and reliable approach which quantifies the chaotic-like nature of LP activity in the time domain is presented here. By establishing the basin of attraction of the LP attractor in the microvoltage, 3-dimensional space, and then computing the fractal dimension (delta) of the attractor's trajectory, the strangeness of the dynamical behaviour of late potentials was quantified. Thus, the parameter delta provides an index of the chaotic behaviour of the terminal dynamic of the ventricular depolarization process which could reflect the patient's susceptibility to VT. In order to study this relationship, the parameter delta was evaluated in a control group of 30 healthy subjects (Group 1) and in 30 post-MI patients which were VT inducibles as a result of programmed electrical stimulation (Group 2). The results of the study indicated that the value of delta was significantly higher (a more chaotic attractor) in Group 2 than in Group 1 (p < 0.001). Thus, these results suggest a close correlation between the chaotic nature of late potentials and the subject's susceptibility to enter into a catastrophic arrhythmia such as VT. A value of delta > 1.3 may be considered as the criterion for discriminating post-MI patients that are at risk or as having chaotic LP activity.
LanguageEnglish
Title of host publicationUnknown Host Publication
EditorsM Cerrolaza, D Jugo, CA Brebbia
Place of PublicationASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA
Pages281-290
Number of pages10
Volume1
Publication statusPublished - 15 Dec 1996
EventInternational Conference on Simulation Modelling in Bioengineering, BIOSIM 96 - Merida, Venezuela
Duration: 15 Dec 1996 → …

Conference

ConferenceInternational Conference on Simulation Modelling in Bioengineering, BIOSIM 96
Period15/12/96 → …

Fingerprint

Cardiac Arrhythmias
Ventricular Tachycardia
Incidence
Electric Stimulation
Fractals
Healthy Volunteers
Electrocardiography
Myocardial Infarction
Control Groups

Keywords

  • Computational methods
  • Computer simulation
  • Fractals
  • Patient monitoring
  • Time domain analysis
  • Catastrophic arrhythmia
  • Late potential (LP) analysis
  • Myocardial infarction (MI)
  • Ventricular tachycardia (VT)
  • Electrocardiography
  • high-resolution ECG.

Cite this

Escalona, OJ. (1996). Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia. In M. Cerrolaza, D. Jugo, & CA. Brebbia (Eds.), Unknown Host Publication (Vol. 1, pp. 281-290). ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA.
Escalona, OJ. / Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia. Unknown Host Publication. editor / M Cerrolaza ; D Jugo ; CA Brebbia. Vol. 1 ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA, 1996. pp. 281-290
@inproceedings{2ca0676754d045a49ad23f8f4db1d056,
title = "Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia",
abstract = "Late potential (LP) analysis in the signal-averaged ECG is a useful clinical tool in the detection of patients at risk after myocardial infarction (Mi). The presence of abnormal LP activity has been correlated with inducible ventricular tachycardia (VT) at programmed electrical stimulation in post-MI patients. A novel and reliable approach which quantifies the chaotic-like nature of LP activity in the time domain is presented here. By establishing the basin of attraction of the LP attractor in the microvoltage, 3-dimensional space, and then computing the fractal dimension (delta) of the attractor's trajectory, the strangeness of the dynamical behaviour of late potentials was quantified. Thus, the parameter delta provides an index of the chaotic behaviour of the terminal dynamic of the ventricular depolarization process which could reflect the patient's susceptibility to VT. In order to study this relationship, the parameter delta was evaluated in a control group of 30 healthy subjects (Group 1) and in 30 post-MI patients which were VT inducibles as a result of programmed electrical stimulation (Group 2). The results of the study indicated that the value of delta was significantly higher (a more chaotic attractor) in Group 2 than in Group 1 (p < 0.001). Thus, these results suggest a close correlation between the chaotic nature of late potentials and the subject's susceptibility to enter into a catastrophic arrhythmia such as VT. A value of delta > 1.3 may be considered as the criterion for discriminating post-MI patients that are at risk or as having chaotic LP activity.",
keywords = "Computational methods, Computer simulation, Fractals, Patient monitoring, Time domain analysis, Catastrophic arrhythmia, Late potential (LP) analysis, Myocardial infarction (MI), Ventricular tachycardia (VT), Electrocardiography, high-resolution ECG.",
author = "OJ Escalona",
year = "1996",
month = "12",
day = "15",
language = "English",
volume = "1",
pages = "281--290",
editor = "M Cerrolaza and D Jugo and CA Brebbia",
booktitle = "Unknown Host Publication",

}

Escalona, OJ 1996, Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia. in M Cerrolaza, D Jugo & CA Brebbia (eds), Unknown Host Publication. vol. 1, ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA, pp. 281-290, International Conference on Simulation Modelling in Bioengineering, BIOSIM 96, 15/12/96.

Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia. / Escalona, OJ.

Unknown Host Publication. ed. / M Cerrolaza; D Jugo; CA Brebbia. Vol. 1 ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA, 1996. p. 281-290.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia

AU - Escalona, OJ

PY - 1996/12/15

Y1 - 1996/12/15

N2 - Late potential (LP) analysis in the signal-averaged ECG is a useful clinical tool in the detection of patients at risk after myocardial infarction (Mi). The presence of abnormal LP activity has been correlated with inducible ventricular tachycardia (VT) at programmed electrical stimulation in post-MI patients. A novel and reliable approach which quantifies the chaotic-like nature of LP activity in the time domain is presented here. By establishing the basin of attraction of the LP attractor in the microvoltage, 3-dimensional space, and then computing the fractal dimension (delta) of the attractor's trajectory, the strangeness of the dynamical behaviour of late potentials was quantified. Thus, the parameter delta provides an index of the chaotic behaviour of the terminal dynamic of the ventricular depolarization process which could reflect the patient's susceptibility to VT. In order to study this relationship, the parameter delta was evaluated in a control group of 30 healthy subjects (Group 1) and in 30 post-MI patients which were VT inducibles as a result of programmed electrical stimulation (Group 2). The results of the study indicated that the value of delta was significantly higher (a more chaotic attractor) in Group 2 than in Group 1 (p < 0.001). Thus, these results suggest a close correlation between the chaotic nature of late potentials and the subject's susceptibility to enter into a catastrophic arrhythmia such as VT. A value of delta > 1.3 may be considered as the criterion for discriminating post-MI patients that are at risk or as having chaotic LP activity.

AB - Late potential (LP) analysis in the signal-averaged ECG is a useful clinical tool in the detection of patients at risk after myocardial infarction (Mi). The presence of abnormal LP activity has been correlated with inducible ventricular tachycardia (VT) at programmed electrical stimulation in post-MI patients. A novel and reliable approach which quantifies the chaotic-like nature of LP activity in the time domain is presented here. By establishing the basin of attraction of the LP attractor in the microvoltage, 3-dimensional space, and then computing the fractal dimension (delta) of the attractor's trajectory, the strangeness of the dynamical behaviour of late potentials was quantified. Thus, the parameter delta provides an index of the chaotic behaviour of the terminal dynamic of the ventricular depolarization process which could reflect the patient's susceptibility to VT. In order to study this relationship, the parameter delta was evaluated in a control group of 30 healthy subjects (Group 1) and in 30 post-MI patients which were VT inducibles as a result of programmed electrical stimulation (Group 2). The results of the study indicated that the value of delta was significantly higher (a more chaotic attractor) in Group 2 than in Group 1 (p < 0.001). Thus, these results suggest a close correlation between the chaotic nature of late potentials and the subject's susceptibility to enter into a catastrophic arrhythmia such as VT. A value of delta > 1.3 may be considered as the criterion for discriminating post-MI patients that are at risk or as having chaotic LP activity.

KW - Computational methods

KW - Computer simulation

KW - Fractals

KW - Patient monitoring

KW - Time domain analysis

KW - Catastrophic arrhythmia

KW - Late potential (LP) analysis

KW - Myocardial infarction (MI)

KW - Ventricular tachycardia (VT)

KW - Electrocardiography

KW - high-resolution ECG.

UR - https://www.scopus.com

UR - https://www.scopus.com

M3 - Conference contribution

VL - 1

SP - 281

EP - 290

BT - Unknown Host Publication

A2 - Cerrolaza, M

A2 - Jugo, D

A2 - Brebbia, CA

CY - ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA

ER -

Escalona OJ. Incidence of chaotic behaviour of ventricular late potentials on patient's susceptibility to a catastrophic arrhythmia. In Cerrolaza M, Jugo D, Brebbia CA, editors, Unknown Host Publication. Vol. 1. ASHURST LODGE, SOUTHAMPTON, HANTS, ENGLAND S04 2AA. 1996. p. 281-290