In vivo NIRS monitoring in pig Spinal Cord tissues

Olivier Tsiakaka; Mehdi Terosiet; Olivier Romain; Aymeric Histace; Habib Benali; Pierre Franois Pradat; Farouk Vallette; Michael Feher; Sylvain Feruglio

doi:10.1109/EMBC.2015.7319336

In vivo NIRS monitoring in pig Spinal Cord tissues

Olivier Tsiakaka, Mehdi Terosiet, Olivier Romain, Aymeric Histace, Habib Benali, Pierre Franois Pradat, Farouk Vallette, Michael Feher, Sylvain Feruglio

School of Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

Little is known about the processes occurring after Spinal Cord damage. Whether permanent or recoverable, those processes have not been precisely characterized because their mechanism is complex and information on the functioning of this organ are partial. This study demonstrates the feasibility of Spinal Cord activity monitoring using Near Infra-Red Spectroscopy in a pig animal model. This animal has been chosen because of its comparable size and its similarities with humans. In the first step, optical characterization of the Spinal Cord tissues was performed in different conditions using a spectrophotometer. Optical Density was evaluated between 3.5 and 6.5 in the [500; 950] nm range. Secondly, adapted light sources with custom probes were used to observe autonomic functions in the spine. Results on the measured haemodynamics at rest and under stimulation show in real time the impact of a global stimulus on a local section of the Spinal Cord. The photoplethysmogram signal of the Spinal Cord showed low AC-to-DC ratio (below to 1 %).

Original language	English
Title of host publication	2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Publisher	IEEE
Pages	4262-4265
Number of pages	4
Volume	2015-November
ISBN (Electronic)	9781424492718
DOIs	https://doi.org/10.1109/EMBC.2015.7319336
Publication status	Published (in print/issue) - 4 Nov 2015
Event	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy Duration: 25 Aug 2015 → 29 Aug 2015

Conference

Conference	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Country/Territory	Italy
City	Milan
Period	25/08/15 → 29/08/15

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10.1109/EMBC.2015.7319336

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Tsiakaka, O., Terosiet, M., Romain, O., Histace, A., Benali, H., Pradat, P. F., Vallette, F., Feher, M., & Feruglio, S. (2015). In vivo NIRS monitoring in pig Spinal Cord tissues. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 (Vol. 2015-November, pp. 4262-4265). Article 7319336 IEEE. https://doi.org/10.1109/EMBC.2015.7319336

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title = "In vivo NIRS monitoring in pig Spinal Cord tissues",

abstract = "Little is known about the processes occurring after Spinal Cord damage. Whether permanent or recoverable, those processes have not been precisely characterized because their mechanism is complex and information on the functioning of this organ are partial. This study demonstrates the feasibility of Spinal Cord activity monitoring using Near Infra-Red Spectroscopy in a pig animal model. This animal has been chosen because of its comparable size and its similarities with humans. In the first step, optical characterization of the Spinal Cord tissues was performed in different conditions using a spectrophotometer. Optical Density was evaluated between 3.5 and 6.5 in the [500; 950] nm range. Secondly, adapted light sources with custom probes were used to observe autonomic functions in the spine. Results on the measured haemodynamics at rest and under stimulation show in real time the impact of a global stimulus on a local section of the Spinal Cord. The photoplethysmogram signal of the Spinal Cord showed low AC-to-DC ratio (below to 1 %).",

author = "Olivier Tsiakaka and Mehdi Terosiet and Olivier Romain and Aymeric Histace and Habib Benali and Pradat, {Pierre Franois} and Farouk Vallette and Michael Feher and Sylvain Feruglio",

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Tsiakaka, O, Terosiet, M, Romain, O, Histace, A, Benali, H, Pradat, PF, Vallette, F, Feher, M & Feruglio, S 2015, In vivo NIRS monitoring in pig Spinal Cord tissues. in 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. vol. 2015-November, 7319336, IEEE, pp. 4262-4265, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 25/08/15. https://doi.org/10.1109/EMBC.2015.7319336

In vivo NIRS monitoring in pig Spinal Cord tissues. / Tsiakaka, Olivier; Terosiet, Mehdi; Romain, Olivier et al.
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Vol. 2015-November IEEE, 2015. p. 4262-4265 7319336.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Tsiakaka, Olivier

AU - Terosiet, Mehdi

AU - Romain, Olivier

AU - Histace, Aymeric

AU - Benali, Habib

AU - Pradat, Pierre Franois

AU - Vallette, Farouk

AU - Feher, Michael

AU - Feruglio, Sylvain

PY - 2015/11/4

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N2 - Little is known about the processes occurring after Spinal Cord damage. Whether permanent or recoverable, those processes have not been precisely characterized because their mechanism is complex and information on the functioning of this organ are partial. This study demonstrates the feasibility of Spinal Cord activity monitoring using Near Infra-Red Spectroscopy in a pig animal model. This animal has been chosen because of its comparable size and its similarities with humans. In the first step, optical characterization of the Spinal Cord tissues was performed in different conditions using a spectrophotometer. Optical Density was evaluated between 3.5 and 6.5 in the [500; 950] nm range. Secondly, adapted light sources with custom probes were used to observe autonomic functions in the spine. Results on the measured haemodynamics at rest and under stimulation show in real time the impact of a global stimulus on a local section of the Spinal Cord. The photoplethysmogram signal of the Spinal Cord showed low AC-to-DC ratio (below to 1 %).

AB - Little is known about the processes occurring after Spinal Cord damage. Whether permanent or recoverable, those processes have not been precisely characterized because their mechanism is complex and information on the functioning of this organ are partial. This study demonstrates the feasibility of Spinal Cord activity monitoring using Near Infra-Red Spectroscopy in a pig animal model. This animal has been chosen because of its comparable size and its similarities with humans. In the first step, optical characterization of the Spinal Cord tissues was performed in different conditions using a spectrophotometer. Optical Density was evaluated between 3.5 and 6.5 in the [500; 950] nm range. Secondly, adapted light sources with custom probes were used to observe autonomic functions in the spine. Results on the measured haemodynamics at rest and under stimulation show in real time the impact of a global stimulus on a local section of the Spinal Cord. The photoplethysmogram signal of the Spinal Cord showed low AC-to-DC ratio (below to 1 %).

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ER -

In vivo NIRS monitoring in pig Spinal Cord tissues

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