In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer

Hamid Bakshi, Murtaza M Tambuwala

Research output: Contribution to journalArticle

Abstract

Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines for cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance of
practicing natural medicines and developing natural product based drugs for cancer treatment. Recently we reported an anti colon cancer activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells in
vitro. To extend our observation in this study we evaluated in vivo colon tumor remission property of acetone extract of A. nilotica (ACE) and pyrogallol. Materials and Methods: In vivo toxicity of ACE and pyrogallol was assessed and
In vivo tumor remission activity of ACE and pyrogallol was determined in murine model. Results: Mice were tolerated different doses of ACE and pyrogallol. Tumor size was considerably reduced in pyrogallol treated mice similar to
doxorubicin. Tumor bearing mice treated with ACE and pyrogallol showed mild decline in body weight. Conclusion: Pyrogallol was found to be an effective anti colon cancer agent with less toxicity.
LanguageEnglish
JournalAsian Pac J Cancer Prev
Volume20
Early online date2 Sep 2019
Publication statusE-pub ahead of print - 2 Sep 2019

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Pyrogallol
Colonic Neoplasms
Neoplasms
Acacia
HT29 Cells
Medicinal Plants
Acetone
Biological Products
Pharmaceutical Preparations
Colon
Body Weight
Observation

Cite this

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title = "In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer",
abstract = "Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines for cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance ofpracticing natural medicines and developing natural product based drugs for cancer treatment. Recently we reported an anti colon cancer activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells invitro. To extend our observation in this study we evaluated in vivo colon tumor remission property of acetone extract of A. nilotica (ACE) and pyrogallol. Materials and Methods: In vivo toxicity of ACE and pyrogallol was assessed andIn vivo tumor remission activity of ACE and pyrogallol was determined in murine model. Results: Mice were tolerated different doses of ACE and pyrogallol. Tumor size was considerably reduced in pyrogallol treated mice similar todoxorubicin. Tumor bearing mice treated with ACE and pyrogallol showed mild decline in body weight. Conclusion: Pyrogallol was found to be an effective anti colon cancer agent with less toxicity.",
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In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer. / Bakshi, Hamid ; Tambuwala, Murtaza M.

In: Asian Pac J Cancer Prev, Vol. 20, 02.09.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer

AU - Bakshi, Hamid

AU - Tambuwala, Murtaza M

PY - 2019/9/2

Y1 - 2019/9/2

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AB - Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines for cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance ofpracticing natural medicines and developing natural product based drugs for cancer treatment. Recently we reported an anti colon cancer activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells invitro. To extend our observation in this study we evaluated in vivo colon tumor remission property of acetone extract of A. nilotica (ACE) and pyrogallol. Materials and Methods: In vivo toxicity of ACE and pyrogallol was assessed andIn vivo tumor remission activity of ACE and pyrogallol was determined in murine model. Results: Mice were tolerated different doses of ACE and pyrogallol. Tumor size was considerably reduced in pyrogallol treated mice similar todoxorubicin. Tumor bearing mice treated with ACE and pyrogallol showed mild decline in body weight. Conclusion: Pyrogallol was found to be an effective anti colon cancer agent with less toxicity.

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