In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer

Hamid Bakshi, Murtaza M Tambuwala

Research output: Contribution to journalArticle

24 Downloads (Pure)

Abstract

Background: Colon cancer is aggressive and it causes 0.5 million deaths per year. Practicing natural medicines for cancer treatment is safer than conventional drugs. World health organization emphasizes on the importance of
practicing natural medicines and developing natural product based drugs for cancer treatment. Recently we reported an anti colon cancer activity associated with pyrogallol isolated from medicinal plant Acacia nilotica in HT-29 cells in
vitro. To extend our observation in this study we evaluated in vivo colon tumor remission property of acetone extract of A. nilotica (ACE) and pyrogallol. Materials and Methods: In vivo toxicity of ACE and pyrogallol was assessed and
In vivo tumor remission activity of ACE and pyrogallol was determined in murine model. Results: Mice were tolerated different doses of ACE and pyrogallol. Tumor size was considerably reduced in pyrogallol treated mice similar to
doxorubicin. Tumor bearing mice treated with ACE and pyrogallol showed mild decline in body weight. Conclusion: Pyrogallol was found to be an effective anti colon cancer agent with less toxicity.
Original languageEnglish
Pages (from-to)2645-2651
Number of pages7
JournalAsian Pac J Cancer Prev
Volume20
Issue number9
Early online date2 Sep 2019
DOIs
Publication statusE-pub ahead of print - 2 Sep 2019

Keywords

  • Acacia nilotica
  • Colon cancer
  • Helicobacter pylori
  • Pyrogallol
  • Toxicity

Fingerprint Dive into the research topics of 'In Vivo Anti Cancer Potential of Pyrogallol in Murine Model of Colon Cancer'. Together they form a unique fingerprint.

  • Cite this