In vitro Modulation of Pancreatic Insulin Secretion and Extra Pancreatic Insulin Action, Enzymatic Starch Digestion and Protein Glycation by Terminalia chebula Extracts

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Abstract

Aim: Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Study Design: Using multiple in vitro models; this study was designed to investigate the efficacy and mode of action of Terminalia chebula Retz. (Combretaceae) used traditionally for treatment of diabetes. Place and Duration of Study: School of Biomedical Sciences, University of Ulster, 2001-2004. Results: T. chebula aqueous extract stimulated basal insulin output and potentiated glucose-stimulated insulin secretion concentration-dependently in the clonal pancreatic beta cell line, BRIN-BD11 (p
LanguageEnglish
Pages771-782
JournalEuropean Journal of Medicinal Plants
Volume4
Issue number7
DOIs
Publication statusPublished - 20 Mar 2014

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Terminalia
Starch
Proteolysis
Combretaceae
Insulin
Insulin-Secreting Cells
Diabetes Mellitus
Glucose
Cell Line
In Vitro Techniques
Therapeutics

Keywords

  • Terminilia chebula Retz. (Combretaceae)
  • insulin secretion
  • insulin action
  • starch digestion
  • peptide glycation.

Cite this

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title = "In vitro Modulation of Pancreatic Insulin Secretion and Extra Pancreatic Insulin Action, Enzymatic Starch Digestion and Protein Glycation by Terminalia chebula Extracts",
abstract = "Aim: Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Study Design: Using multiple in vitro models; this study was designed to investigate the efficacy and mode of action of Terminalia chebula Retz. (Combretaceae) used traditionally for treatment of diabetes. Place and Duration of Study: School of Biomedical Sciences, University of Ulster, 2001-2004. Results: T. chebula aqueous extract stimulated basal insulin output and potentiated glucose-stimulated insulin secretion concentration-dependently in the clonal pancreatic beta cell line, BRIN-BD11 (p",
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author = "V Kasabri and Peter Flatt and YHA Abdel-Wahab",
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AU - Flatt, Peter

AU - Abdel-Wahab, YHA

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AB - Aim: Traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. Study Design: Using multiple in vitro models; this study was designed to investigate the efficacy and mode of action of Terminalia chebula Retz. (Combretaceae) used traditionally for treatment of diabetes. Place and Duration of Study: School of Biomedical Sciences, University of Ulster, 2001-2004. Results: T. chebula aqueous extract stimulated basal insulin output and potentiated glucose-stimulated insulin secretion concentration-dependently in the clonal pancreatic beta cell line, BRIN-BD11 (p

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KW - insulin action

KW - starch digestion

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