In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery

Eleni Kontogiannidou, Martina Ferrari, Asteria-danai Deligianni, Nikolaos Bouropoulos, Dimitrios A. Andreadis, Milena Sorrenti, Laura Catenacci, Kazem Nazari, Muhammad Sohail Arshad, Ming-wei Chang, Zeeshan Ahmad, Dimitrios G. Fatouros

Research output: Contribution to journalArticle

Abstract

In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.
LanguageEnglish
Article number398
Pages1-12
Number of pages12
JournalPharmaceutics
Volume11
Issue number8
DOIs
Publication statusPublished - 8 Aug 2019

Fingerprint

Piroxicam
Cheek
Cyclodextrins
Tablets
Chitosan
Pharmaceutical Preparations
Differential Scanning Calorimetry
Mouth Mucosa
Saliva
Powders
Spectrum Analysis
Polymers
Anti-Inflammatory Agents
Swine
X-Rays
In Vitro Techniques
betadex
2-hydroxypropyl-beta-cyclodextrin

Keywords

  • cyclodextrins
  • in vitro studies
  • ex vivo buccal permeation
  • Ex vivo buccal permeation
  • Cyclodextrins
  • In vitro studies

Cite this

Kontogiannidou, E., Ferrari, M., Deligianni, A., Bouropoulos, N., Andreadis, D. A., Sorrenti, M., ... Fatouros, D. G. (2019). In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery. Pharmaceutics, 11(8), 1-12. [398]. https://doi.org/10.3390/pharmaceutics11080398
Kontogiannidou, Eleni ; Ferrari, Martina ; Deligianni, Asteria-danai ; Bouropoulos, Nikolaos ; Andreadis, Dimitrios A. ; Sorrenti, Milena ; Catenacci, Laura ; Nazari, Kazem ; Arshad, Muhammad Sohail ; Chang, Ming-wei ; Ahmad, Zeeshan ; Fatouros, Dimitrios G. / In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery. In: Pharmaceutics. 2019 ; Vol. 11, No. 8. pp. 1-12.
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Kontogiannidou, E, Ferrari, M, Deligianni, A, Bouropoulos, N, Andreadis, DA, Sorrenti, M, Catenacci, L, Nazari, K, Arshad, MS, Chang, M, Ahmad, Z & Fatouros, DG 2019, 'In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery', Pharmaceutics, vol. 11, no. 8, 398, pp. 1-12. https://doi.org/10.3390/pharmaceutics11080398

In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery. / Kontogiannidou, Eleni; Ferrari, Martina; Deligianni, Asteria-danai; Bouropoulos, Nikolaos; Andreadis, Dimitrios A.; Sorrenti, Milena; Catenacci, Laura; Nazari, Kazem; Arshad, Muhammad Sohail; Chang, Ming-wei; Ahmad, Zeeshan; Fatouros, Dimitrios G.

In: Pharmaceutics, Vol. 11, No. 8, 398, 08.08.2019, p. 1-12.

Research output: Contribution to journalArticle

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AU - Kontogiannidou, Eleni

AU - Ferrari, Martina

AU - Deligianni, Asteria-danai

AU - Bouropoulos, Nikolaos

AU - Andreadis, Dimitrios A.

AU - Sorrenti, Milena

AU - Catenacci, Laura

AU - Nazari, Kazem

AU - Arshad, Muhammad Sohail

AU - Chang, Ming-wei

AU - Ahmad, Zeeshan

AU - Fatouros, Dimitrios G.

N1 - Fully open access - final published version uploaded

PY - 2019/8/8

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Kontogiannidou E, Ferrari M, Deligianni A, Bouropoulos N, Andreadis DA, Sorrenti M et al. In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery. Pharmaceutics. 2019 Aug 8;11(8):1-12. 398. https://doi.org/10.3390/pharmaceutics11080398