TY - JOUR
T1 - In Vitro and Ex Vivo Evaluation of Tablets Containing Piroxicam-Cyclodextrin Complexes for Buccal Delivery
AU - Kontogiannidou, Eleni
AU - Ferrari, Martina
AU - Deligianni, Asteria-danai
AU - Bouropoulos, Nikolaos
AU - Andreadis, Dimitrios A.
AU - Sorrenti, Milena
AU - Catenacci, Laura
AU - Nazari, Kazem
AU - Arshad, Muhammad Sohail
AU - Chang, Ming-wei
AU - Ahmad, Zeeshan
AU - Fatouros, Dimitrios G.
PY - 2019/8/8
Y1 - 2019/8/8
N2 - In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.
AB - In the current study, the development of mucoadhesive tablets for buccal delivery of a non-steroidal anti-inflammatory drug was investigated. Binary complexes with piroxicam and cyclodextrins (β-cyclodextrin (β-CD), methylated-β-cyclodextrin (Me-β-CD), and hydroxypropyl-β-cyclodextrin (HP-β-CD)) were prepared by the co-evaporation method. All formulations were characterized by means of differential scanning calorimetry, infrared spectroscopy and powder X-ray diffractometry. Mucoadhesive tablets of binary systems were formulated by direct compression using chitosan as mucoadhesive polymer. The in vitro release profiles of tablets were conducted in simulated saliva and, the drug permeation studies, across porcine buccal mucosa. The results suggest that the rank order effect of cyclodextrins for the drug release was Me-β-CD > HP-β-CD > β-CD, whereas the ex vivo studies showed that the tablets containing chitosan significantly increased the transport of the drug compared to their free complexes. Finally, histological assessment revealed loss of the superficial cell layers, which might be attributed to the presence of cyclodextrins.
KW - cyclodextrins
KW - in vitro studies
KW - ex vivo buccal permeation
KW - Ex vivo buccal permeation
KW - Cyclodextrins
KW - In vitro studies
UR - http://www.scopus.com/inward/record.url?scp=85070819591&partnerID=8YFLogxK
U2 - 10.3390/pharmaceutics11080398
DO - 10.3390/pharmaceutics11080398
M3 - Article
C2 - 31398833
SN - 1999-4923
VL - 11
SP - 1
EP - 12
JO - Pharmaceutics
JF - Pharmaceutics
IS - 8
M1 - 398
ER -