IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes

D Dao, D Frank, NF Qian, D O'Keefe, RJ Vosatka, CP Walsh, B Tycko

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Human chromosome 11p15.5 and distal mouse chromosome 7 include a megabase-scale chromosomal domain with multiple genes subject to parental imprinting, Here we describe mouse and human versions of a novel imprinted gene, IMPT1, which lies between IPL and p57(KIP2) and which encodes a predicted multi-membrane-spanning protein similar to bacterial and eukaryotic polyspecific metabolite transporter and multi-drug resistance pumps. Mouse Impt1 and human IMPT1 mRNAs are highly expressed in tissues with metabolite transport functions, including liver, kidney, intestine, extra-embryonic membranes and placenta, and there is strongly preferential expression of the maternal allele in various mouse tissues at fetal stages. In post-natal tissues there is persistent expression, but the allelic bias attenuates. An allelic expression bias is also observed in human fetal and postnatal tissues, but there is significant interindividual variation and rare somatic allele switching. The fact that Impt1 is relatively repressed on the paternal allele, together with data from other imprinted genes, allows a statistical conclusion that the primary effect of human chromosome 11p15.5/mouse distal chromosome 7 imprinting is domain-wide relative repression of genes on the paternal homolog. Dosage regulation of the metabolite transporter gene(s) by imprinting might regulate placental and fetal growth.
LanguageEnglish
Pages597-608
JournalHuman Molecular Genetics
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 1998

Fingerprint

Multiple Drug Resistance
Chromosomes, Human, Pair 7
Genes
Alleles
Human Chromosomes
Fetus
Genomic Imprinting
Extraembryonic Membranes
Fetal Development
Placenta
Intestines
Membrane Proteins
Mothers
Kidney
Messenger RNA
Liver

Cite this

Dao, D ; Frank, D ; Qian, NF ; O'Keefe, D ; Vosatka, RJ ; Walsh, CP ; Tycko, B. / IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. In: Human Molecular Genetics. 1998 ; Vol. 7, No. 4. pp. 597-608.
@article{a612c3e48292419abaff72faaa65aec4,
title = "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes",
abstract = "Human chromosome 11p15.5 and distal mouse chromosome 7 include a megabase-scale chromosomal domain with multiple genes subject to parental imprinting, Here we describe mouse and human versions of a novel imprinted gene, IMPT1, which lies between IPL and p57(KIP2) and which encodes a predicted multi-membrane-spanning protein similar to bacterial and eukaryotic polyspecific metabolite transporter and multi-drug resistance pumps. Mouse Impt1 and human IMPT1 mRNAs are highly expressed in tissues with metabolite transport functions, including liver, kidney, intestine, extra-embryonic membranes and placenta, and there is strongly preferential expression of the maternal allele in various mouse tissues at fetal stages. In post-natal tissues there is persistent expression, but the allelic bias attenuates. An allelic expression bias is also observed in human fetal and postnatal tissues, but there is significant interindividual variation and rare somatic allele switching. The fact that Impt1 is relatively repressed on the paternal allele, together with data from other imprinted genes, allows a statistical conclusion that the primary effect of human chromosome 11p15.5/mouse distal chromosome 7 imprinting is domain-wide relative repression of genes on the paternal homolog. Dosage regulation of the metabolite transporter gene(s) by imprinting might regulate placental and fetal growth.",
author = "D Dao and D Frank and NF Qian and D O'Keefe and RJ Vosatka and CP Walsh and B Tycko",
year = "1998",
month = "4",
doi = "10.1093/hmg/7.4.597",
language = "English",
volume = "7",
pages = "597--608",
journal = "Human Molecular Genetics",
issn = "0964-6906",
number = "4",

}

IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. / Dao, D; Frank, D; Qian, NF; O'Keefe, D; Vosatka, RJ; Walsh, CP; Tycko, B.

In: Human Molecular Genetics, Vol. 7, No. 4, 04.1998, p. 597-608.

Research output: Contribution to journalArticle

TY - JOUR

T1 - IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes

AU - Dao, D

AU - Frank, D

AU - Qian, NF

AU - O'Keefe, D

AU - Vosatka, RJ

AU - Walsh, CP

AU - Tycko, B

PY - 1998/4

Y1 - 1998/4

N2 - Human chromosome 11p15.5 and distal mouse chromosome 7 include a megabase-scale chromosomal domain with multiple genes subject to parental imprinting, Here we describe mouse and human versions of a novel imprinted gene, IMPT1, which lies between IPL and p57(KIP2) and which encodes a predicted multi-membrane-spanning protein similar to bacterial and eukaryotic polyspecific metabolite transporter and multi-drug resistance pumps. Mouse Impt1 and human IMPT1 mRNAs are highly expressed in tissues with metabolite transport functions, including liver, kidney, intestine, extra-embryonic membranes and placenta, and there is strongly preferential expression of the maternal allele in various mouse tissues at fetal stages. In post-natal tissues there is persistent expression, but the allelic bias attenuates. An allelic expression bias is also observed in human fetal and postnatal tissues, but there is significant interindividual variation and rare somatic allele switching. The fact that Impt1 is relatively repressed on the paternal allele, together with data from other imprinted genes, allows a statistical conclusion that the primary effect of human chromosome 11p15.5/mouse distal chromosome 7 imprinting is domain-wide relative repression of genes on the paternal homolog. Dosage regulation of the metabolite transporter gene(s) by imprinting might regulate placental and fetal growth.

AB - Human chromosome 11p15.5 and distal mouse chromosome 7 include a megabase-scale chromosomal domain with multiple genes subject to parental imprinting, Here we describe mouse and human versions of a novel imprinted gene, IMPT1, which lies between IPL and p57(KIP2) and which encodes a predicted multi-membrane-spanning protein similar to bacterial and eukaryotic polyspecific metabolite transporter and multi-drug resistance pumps. Mouse Impt1 and human IMPT1 mRNAs are highly expressed in tissues with metabolite transport functions, including liver, kidney, intestine, extra-embryonic membranes and placenta, and there is strongly preferential expression of the maternal allele in various mouse tissues at fetal stages. In post-natal tissues there is persistent expression, but the allelic bias attenuates. An allelic expression bias is also observed in human fetal and postnatal tissues, but there is significant interindividual variation and rare somatic allele switching. The fact that Impt1 is relatively repressed on the paternal allele, together with data from other imprinted genes, allows a statistical conclusion that the primary effect of human chromosome 11p15.5/mouse distal chromosome 7 imprinting is domain-wide relative repression of genes on the paternal homolog. Dosage regulation of the metabolite transporter gene(s) by imprinting might regulate placental and fetal growth.

U2 - 10.1093/hmg/7.4.597

DO - 10.1093/hmg/7.4.597

M3 - Article

VL - 7

SP - 597

EP - 608

JO - Human Molecular Genetics

T2 - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 4

ER -