Improved transdermal delivery of cetirizine hydrochloride using polymeric microneedles

Muhammad Sohail Arshad, Sana Hassan, Amjad Hussain, Nasir Abbas, Israfil Kucuk, Kazem Nazari, Radeyah Ali, Suleman Ramzan, Ali Alqahtani, Eleftherios G. Andriotis, Dimitris G. Fatouros, Ming Wei Chang, Zeeshan Ahmad

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    3 Citations (Scopus)

    Abstract

    Purpose: The aim of this study was to design and characterize microneedle patch formulation containing cetirizine hydrochloride. Methods: Chitosan was co-formulated with cetirizine hydrochloride. Transdermal patches were prepared by casting this solution to microneedle molds. Control patches were formulated by casting this solution to a plain cuvet of same area as mold but lacking microneedles. An array of methods namely; differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) were employed for the characterization of the films and the microneedles accordingly whereas in vitro permeation studies were conducted across rat skin. Light microscopy was performed to assess any histological changes upon microneedles application onto the rat skin. Results: The patches had a reproducible thickness (0.86 ± 0.06 mm) and folding endurance. Both the blank and drug loaded patches had 100 microneedles each of 300 micrometre length. In addition, the microneedle patches were ascribed with a two-fold increase in drug permeation across rat skin in the presence of microneedles as compared to the control formulations. Histological examination confirms a minimal invasion of the skin conferred by the microneedles. Conclusion: The microneedle patches serve as an alternate route of drug administration in patients with nausea and swelling difficulties. [Figure not available: see fulltext.].

    Original languageEnglish
    Pages (from-to)673-681
    Number of pages9
    JournalDARU, Journal of Pharmaceutical Sciences
    Volume27
    Issue number2
    DOIs
    Publication statusPublished - 1 Dec 2019

    Keywords

    • Cetirizine Hydrochloride
    • Microneedles
    • Transdermal Drug delivery

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  • Cite this

    Arshad, M. S., Hassan, S., Hussain, A., Abbas, N., Kucuk, I., Nazari, K., Ali, R., Ramzan, S., Alqahtani, A., Andriotis, E. G., Fatouros, D. G., Chang, M. W., & Ahmad, Z. (2019). Improved transdermal delivery of cetirizine hydrochloride using polymeric microneedles. DARU, Journal of Pharmaceutical Sciences, 27(2), 673-681. https://doi.org/10.1007/s40199-019-00301-3