Improved recording of atrial activity by modified bipolar leads derived from the 12-lead electrocardiogram

Kennedy Alan, Dewar Finlay, Daniel Guldenring, Raymond Bond, McEneaney David, Aaron Peace, James McLaughlin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study investigates the use of multivariate linear regression to estimate three bipolar ECG leads from the 12-lead ECG in order to improve P-wave signal strength. The study population consisted of body surface potential maps recorded from 229 healthy subjects. P-waves were then isolated and population based transformation weights developed. A derived P-lead (measured between the right sternoclavicular joint and midway along the costal margin in line with the seventh intercostal space) demonstrated significant improvement in median P-wave root mean square (RMS) signal strength when compared to lead II (94 μV vs. 76 μV, p <0.001). A derived ES lead (from the EASI lead system) also showed small but significant improvement in median P-wave RMS (79 μV vs. 76 μV, p = 0.0054). Finally, a derived modified Lewis lead did not improve median P-wave RMS when compared to lead II. However, this derived lead improved atrioventricular RMS ratio. P-wave leads derived from the 12-lead ECG can improve signal-to-noise ratio of the P-wave; this may improve the performance of detection algorithms that rely on P-wave analysis.
LanguageEnglish
Pages1017-1021
JournalJournal of Electrocardiology
Volume48
Issue number6
DOIs
Publication statusPublished - 1 Nov 2015

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P-wave
signal-to-noise ratio

Keywords

  • ECG
  • data science
  • health informatics

Cite this

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title = "Improved recording of atrial activity by modified bipolar leads derived from the 12-lead electrocardiogram",
abstract = "This study investigates the use of multivariate linear regression to estimate three bipolar ECG leads from the 12-lead ECG in order to improve P-wave signal strength. The study population consisted of body surface potential maps recorded from 229 healthy subjects. P-waves were then isolated and population based transformation weights developed. A derived P-lead (measured between the right sternoclavicular joint and midway along the costal margin in line with the seventh intercostal space) demonstrated significant improvement in median P-wave root mean square (RMS) signal strength when compared to lead II (94 μV vs. 76 μV, p <0.001). A derived ES lead (from the EASI lead system) also showed small but significant improvement in median P-wave RMS (79 μV vs. 76 μV, p = 0.0054). Finally, a derived modified Lewis lead did not improve median P-wave RMS when compared to lead II. However, this derived lead improved atrioventricular RMS ratio. P-wave leads derived from the 12-lead ECG can improve signal-to-noise ratio of the P-wave; this may improve the performance of detection algorithms that rely on P-wave analysis.",
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Improved recording of atrial activity by modified bipolar leads derived from the 12-lead electrocardiogram. / Alan, Kennedy; Finlay, Dewar; Guldenring, Daniel; Bond, Raymond; David, McEneaney; Peace, Aaron; McLaughlin, James.

In: Journal of Electrocardiology, Vol. 48, No. 6, 01.11.2015, p. 1017-1021.

Research output: Contribution to journalArticle

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T1 - Improved recording of atrial activity by modified bipolar leads derived from the 12-lead electrocardiogram

AU - Alan, Kennedy

AU - Finlay, Dewar

AU - Guldenring, Daniel

AU - Bond, Raymond

AU - David, McEneaney

AU - Peace, Aaron

AU - McLaughlin, James

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N2 - This study investigates the use of multivariate linear regression to estimate three bipolar ECG leads from the 12-lead ECG in order to improve P-wave signal strength. The study population consisted of body surface potential maps recorded from 229 healthy subjects. P-waves were then isolated and population based transformation weights developed. A derived P-lead (measured between the right sternoclavicular joint and midway along the costal margin in line with the seventh intercostal space) demonstrated significant improvement in median P-wave root mean square (RMS) signal strength when compared to lead II (94 μV vs. 76 μV, p <0.001). A derived ES lead (from the EASI lead system) also showed small but significant improvement in median P-wave RMS (79 μV vs. 76 μV, p = 0.0054). Finally, a derived modified Lewis lead did not improve median P-wave RMS when compared to lead II. However, this derived lead improved atrioventricular RMS ratio. P-wave leads derived from the 12-lead ECG can improve signal-to-noise ratio of the P-wave; this may improve the performance of detection algorithms that rely on P-wave analysis.

AB - This study investigates the use of multivariate linear regression to estimate three bipolar ECG leads from the 12-lead ECG in order to improve P-wave signal strength. The study population consisted of body surface potential maps recorded from 229 healthy subjects. P-waves were then isolated and population based transformation weights developed. A derived P-lead (measured between the right sternoclavicular joint and midway along the costal margin in line with the seventh intercostal space) demonstrated significant improvement in median P-wave root mean square (RMS) signal strength when compared to lead II (94 μV vs. 76 μV, p <0.001). A derived ES lead (from the EASI lead system) also showed small but significant improvement in median P-wave RMS (79 μV vs. 76 μV, p = 0.0054). Finally, a derived modified Lewis lead did not improve median P-wave RMS when compared to lead II. However, this derived lead improved atrioventricular RMS ratio. P-wave leads derived from the 12-lead ECG can improve signal-to-noise ratio of the P-wave; this may improve the performance of detection algorithms that rely on P-wave analysis.

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