Imprint stability and plasticity during development

Sarah Jayne Mackin, Avinash Thakur, Colum P. Walsh

    Research output: Contribution to journalReview article

    1 Citation (Scopus)

    Abstract

    There have been a number of recent insights in the area of genomic imprinting, the phenomenon whereby one of two autosomal alleles is selected for expression based on the parent of origin. This is due in part to a proliferation of new techniques for interrogating the genome that are leading researchers working on organisms other than mouse and human, where imprinting has been most studied, to become interested in looking for potential imprinting effects. Here, we recap what is known about the importance of imprints for growth and body size, as well as the main types of locus control. Interestingly, work from a number of labs has now shown that maintenance of the imprint post implantation appears to be a more crucial step than previously appreciated. We ask whether imprints can be reprogrammed somatically, how many loci there are and how conserved imprinted regions are in other species. Finally, we survey some of the methods available for examining DNA methylation genome-wide and look to the future of this burgeoning field.

    LanguageEnglish
    PagesR43-R55
    JournalReproduction
    Volume156
    Issue number2
    DOIs
    Publication statusPublished - 1 Jan 2018

    Fingerprint

    Genome
    Genomic Imprinting
    Internal-External Control
    Body Size
    DNA Methylation
    Alleles
    Maintenance
    Research Personnel
    Growth
    Imprinting (Psychology)
    Surveys and Questionnaires

    Cite this

    Mackin, Sarah Jayne ; Thakur, Avinash ; Walsh, Colum P. / Imprint stability and plasticity during development. In: Reproduction. 2018 ; Vol. 156, No. 2. pp. R43-R55.
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    Imprint stability and plasticity during development. / Mackin, Sarah Jayne; Thakur, Avinash; Walsh, Colum P.

    In: Reproduction, Vol. 156, No. 2, 01.01.2018, p. R43-R55.

    Research output: Contribution to journalReview article

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