Importance of STAT3 signalling in cancer, metastasis and therapeutic interventions

Mohamed El-tanani, Arwa Omar Al Khatib, Safwan Mahmoud Aladwan, Ahmed Abuelhana, Paul A. Mccarron, Murtaza M. Tambuwala

Research output: Contribution to journalArticlepeer-review

Abstract

The Signal Transducer and Activator of Transcription 3 (STAT3) protein is encoded on chromosome 17q21. The SH2 and the DNA binding domains are critical structural components of the protein, together with tyrosine and serine residues that initiate phosphorylation. STAT3 interacts with DNA directly and functions in cells as both a signal transducer and a transcription factor. Its cytoplasmic activation results in dimerisation and nuclear translocation, where it is involved in the transcription of a large number of target genes. STAT3 is hyperactive in cancer cells as a result of upstream STAT3 mutations or enhanced cytokine production in the tumour environment. The STAT3 signalling pathway promotes many hallmarks of carcinogenesis and metastasis, including enhanced cell proliferation and survival, as well as migration and invasion into the extracellular matrix. Recent investigations into novel STAT3-based therapies describe a range of innovative approaches, such as the use of novel oligonucleotide drugs. These limit STAT3 binding to its target genes by attaching to SH2 and DNA-binding domains. Yet, despite these significant steps in understanding the underpinning mechanisms, there are currently no therapeutic agents that addresses STAT3 signalling in a clinically relevant manner.
Original languageEnglish
Article number110275
Pages (from-to)1-7
Number of pages7
JournalCellular Signalling
Volume92
Early online date3 Feb 2022
DOIs
Publication statusPublished - 30 Apr 2022

Bibliographical note

Publisher Copyright:
© 2022

Keywords

  • stat3
  • Cancer
  • cellular signalling
  • therapeutic interventions
  • Angiogenesis
  • STAT3 inhibitors
  • STAT
  • Cell invasion
  • Cancer & metastasis
  • Cell migration

Fingerprint

Dive into the research topics of 'Importance of STAT3 signalling in cancer, metastasis and therapeutic interventions'. Together they form a unique fingerprint.

Cite this