Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease.

Talib Abbas, Emilie Faivre, Christian Holscher

    Research output: Contribution to journalArticle

    Abstract

    Type 2 diabetes has been identified as a risk factor for Alzheimer disease (AD). Insulin signalling is often impaired in AD, contributing to the neurodegeneration seen in AD. Previous studies have shown that the incretin glucagon-like peptide 1 (GLP-1) helps to normalise insulin signalling in type 2 diabetes. GLP-1 also plays important roles in neuronal activity and brain functions. We tested the specific role of GLP-1 receptors in synaptic plasticity and cognitive processes in a GLP-1 receptor knockout (Glp1r(-/-)) mouse model. In an open field assessment, no general difference in exploratory and anxiety was found except for a small decrease in running speed was found (p
    LanguageEnglish
    Pages265-71
    JournalBehavioural Brain Research
    Volume205
    Issue number1
    Publication statusPublished - 2009

    Fingerprint

    Neuronal Plasticity
    Type 2 Diabetes Mellitus
    Alzheimer Disease
    Glucagon-Like Peptide 1
    Insulin
    Incretins
    Knockout Mice
    Running
    Anxiety
    Brain
    Glucagon-Like Peptide-1 Receptor

    Cite this

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    Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. / Abbas, Talib; Faivre, Emilie; Holscher, Christian.

    In: Behavioural Brain Research, Vol. 205, No. 1, 2009, p. 265-71.

    Research output: Contribution to journalArticle

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