Impaired mechanical strength of bone in experimental copper deficiency

J Jonas, J Burns, EW Abel, MJ Cresswell, JJ Strain, CR Paterson

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Copper, through its role as cofactor for lysyl oxidase, is essential for intra- and inter-molecular cross-links in collagen. Copper deficiency, in man and in animals, is associated with bone fragility ascribed to defective cross-links. To assess bone strength in copper-deficient animals, we designed a sensitive torsion-testing apparatus according to biomechanical considerations. Femora from 7 copper-deficient rats and from their pair-fed controls were tested in torsional loading until fracture. Significant decreases in the maximal sustained torque (t = 2.93, p < 0.05), in the ultimate angular deformation (t = 2.52, p < 0.05) and in the toughness (t = 2.88, p < 0.05) were demonstrated. In a complementary study, it was shown that the ash weight and the calcium content of the femora from the copper-deficient animals did not differ from those of the controls. It was likely, therefore, that the impaired mechanical strength was related to defects in the collagen component of bone.
LanguageEnglish
Pages245-252
JournalAnnals of Nutrition and Metabolism
Volume37
Issue number5
Publication statusPublished - Sep 1993

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Copper
Bone and Bones
Femur
Collagen
Protein-Lysine 6-Oxidase
Torque
Calcium
Weights and Measures

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Jonas, J., Burns, J., Abel, EW., Cresswell, MJ., Strain, JJ., & Paterson, CR. (1993). Impaired mechanical strength of bone in experimental copper deficiency. Annals of Nutrition and Metabolism, 37(5), 245-252.
Jonas, J ; Burns, J ; Abel, EW ; Cresswell, MJ ; Strain, JJ ; Paterson, CR. / Impaired mechanical strength of bone in experimental copper deficiency. In: Annals of Nutrition and Metabolism. 1993 ; Vol. 37, No. 5. pp. 245-252.
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Jonas, J, Burns, J, Abel, EW, Cresswell, MJ, Strain, JJ & Paterson, CR 1993, 'Impaired mechanical strength of bone in experimental copper deficiency', Annals of Nutrition and Metabolism, vol. 37, no. 5, pp. 245-252.

Impaired mechanical strength of bone in experimental copper deficiency. / Jonas, J; Burns, J; Abel, EW; Cresswell, MJ; Strain, JJ; Paterson, CR.

In: Annals of Nutrition and Metabolism, Vol. 37, No. 5, 09.1993, p. 245-252.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impaired mechanical strength of bone in experimental copper deficiency

AU - Jonas, J

AU - Burns, J

AU - Abel, EW

AU - Cresswell, MJ

AU - Strain, JJ

AU - Paterson, CR

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AB - Copper, through its role as cofactor for lysyl oxidase, is essential for intra- and inter-molecular cross-links in collagen. Copper deficiency, in man and in animals, is associated with bone fragility ascribed to defective cross-links. To assess bone strength in copper-deficient animals, we designed a sensitive torsion-testing apparatus according to biomechanical considerations. Femora from 7 copper-deficient rats and from their pair-fed controls were tested in torsional loading until fracture. Significant decreases in the maximal sustained torque (t = 2.93, p < 0.05), in the ultimate angular deformation (t = 2.52, p < 0.05) and in the toughness (t = 2.88, p < 0.05) were demonstrated. In a complementary study, it was shown that the ash weight and the calcium content of the femora from the copper-deficient animals did not differ from those of the controls. It was likely, therefore, that the impaired mechanical strength was related to defects in the collagen component of bone.

M3 - Article

VL - 37

SP - 245

EP - 252

JO - Annals of Nutrition and Metabolism

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Jonas J, Burns J, Abel EW, Cresswell MJ, Strain JJ, Paterson CR. Impaired mechanical strength of bone in experimental copper deficiency. Annals of Nutrition and Metabolism. 1993 Sep;37(5):245-252.