Abstract
| Language | English |
|---|---|
| Pages | 245-252 |
| Journal | Annals of Nutrition and Metabolism |
| Volume | 37 |
| Issue number | 5 |
| Publication status | Published - Sep 1993 |
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Impaired mechanical strength of bone in experimental copper deficiency. / Jonas, J; Burns, J; Abel, EW; Cresswell, MJ; Strain, JJ; Paterson, CR.
In: Annals of Nutrition and Metabolism, Vol. 37, No. 5, 09.1993, p. 245-252.Research output: Contribution to journal › Article
TY - JOUR
T1 - Impaired mechanical strength of bone in experimental copper deficiency
AU - Jonas, J
AU - Burns, J
AU - Abel, EW
AU - Cresswell, MJ
AU - Strain, JJ
AU - Paterson, CR
PY - 1993/9
Y1 - 1993/9
N2 - Copper, through its role as cofactor for lysyl oxidase, is essential for intra- and inter-molecular cross-links in collagen. Copper deficiency, in man and in animals, is associated with bone fragility ascribed to defective cross-links. To assess bone strength in copper-deficient animals, we designed a sensitive torsion-testing apparatus according to biomechanical considerations. Femora from 7 copper-deficient rats and from their pair-fed controls were tested in torsional loading until fracture. Significant decreases in the maximal sustained torque (t = 2.93, p < 0.05), in the ultimate angular deformation (t = 2.52, p < 0.05) and in the toughness (t = 2.88, p < 0.05) were demonstrated. In a complementary study, it was shown that the ash weight and the calcium content of the femora from the copper-deficient animals did not differ from those of the controls. It was likely, therefore, that the impaired mechanical strength was related to defects in the collagen component of bone.
AB - Copper, through its role as cofactor for lysyl oxidase, is essential for intra- and inter-molecular cross-links in collagen. Copper deficiency, in man and in animals, is associated with bone fragility ascribed to defective cross-links. To assess bone strength in copper-deficient animals, we designed a sensitive torsion-testing apparatus according to biomechanical considerations. Femora from 7 copper-deficient rats and from their pair-fed controls were tested in torsional loading until fracture. Significant decreases in the maximal sustained torque (t = 2.93, p < 0.05), in the ultimate angular deformation (t = 2.52, p < 0.05) and in the toughness (t = 2.88, p < 0.05) were demonstrated. In a complementary study, it was shown that the ash weight and the calcium content of the femora from the copper-deficient animals did not differ from those of the controls. It was likely, therefore, that the impaired mechanical strength was related to defects in the collagen component of bone.
M3 - Article
VL - 37
SP - 245
EP - 252
JO - Annals of Nutrition and Metabolism
T2 - Annals of Nutrition and Metabolism
JF - Annals of Nutrition and Metabolism
SN - 0250-6807
IS - 5
ER -