Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults

Martina Rooney; Catherine F Hughes; J J Strain; Michelle Clements; Helene McNulty; Mary Ward

doi:10.1111/jhn.13061

Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults

Martina Rooney, Catherine F Hughes, J J Strain, Michelle Clements, Helene McNulty, Mary Ward

Research output: Contribution to journal › Article › peer-review

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Abstract

BACKGROUND: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk of hypertension and cardiovascular disease. Riboflavin, the MTHFR cofactor, is an important modulator of blood pressure (BP) in adults homozygous for this polymorphism (TT genotype). The effect of this genetic variant on BP and related central haemodynamic parameters in healthy adults has not been previously investigated and was examined in this study.

METHODS: Brachial BP, central BP and pulse wave velocity (PWV, SphygmoCor XCEL) were measured in adults aged 18-65 years prescreened for MTHFR genotype. Riboflavin status was assessed using the erythrocyte glutathione reductase activation coefficient assay.

RESULTS: Two hundred and forty-two adults with the MTHFR 677TT genotype and age-matched non-TT (CC/CT) genotype controls were identified from a total cohort of 2546 adults prescreened for MTHFR genotype. The TT genotype was found to be an independent determinant of hypertension (p = 0.010), along with low-riboflavin status (p = 0.002). Brachial systolic and diastolic BP were higher in TT versus non-TT adults by 5.5 ± 1.2 and 2.4 ± 0.9 mmHg, respectively (both p < 0.001). A stronger phenotype was observed in women, with an almost 10 mmHg difference in mean systolic BP in TT versus non-TT genotype groups: 134.9 (95% confidence interval [CI] 132.1-137.6) versus 125.2 (95% CI 122.3-128.0) mmHg; p < 0.001. In addition, PWV was faster in women with the TT genotype (p = 0.043).

CONCLUSION: This study provides the first evidence that brachial and central BP are significantly higher in adults with the variant MTHFR 677TT genotype and that the BP phenotype is more pronounced in women.

Original language	English
Pages (from-to)	689-700
Number of pages	12
Journal	Journal of Human Nutrition and Dietetics
Volume	35
Issue number	4
Early online date	12 Jul 2022
DOIs	https://doi.org/10.1111/jhn.13061
Publication status	Published (in print/issue) - 2 Aug 2022

Bibliographical note

Funding Information:
This work was supported, in part, by Ulster University funding from the Vice Chancellors Research Fund, which funded PhD studentship for Martina Rooney, and the Northern Ireland Clinical Research Facility. None of these entities were involved in the design, implementation, analysis or interpretation of the data.

Publisher Copyright:
© 2022 The Authors. Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association.

Keywords

blood pressure
personalised nutrition
methylenetetrahydrofolate reductase
hypertension
haemodynamics
riboflavin
Medicine (miscellaneous)
Nutrition and Dietetics
Hypertension/genetics
Pulse Wave Analysis
Humans
Genotype
Riboflavin/genetics
Blood Pressure/genetics
Methylenetetrahydrofolate Reductase (NADPH2)/genetics
Female

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jhn.13061

J Human Nutrition Diet - 2022 - Rooney - Impact of the MTHFR C677T polymorphism on blood pressure and related central (1)Final published version, 984 KBLicence: CC BY

Cite this

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title = "Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults",

abstract = "BACKGROUND: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk of hypertension and cardiovascular disease. Riboflavin, the MTHFR cofactor, is an important modulator of blood pressure (BP) in adults homozygous for this polymorphism (TT genotype). The effect of this genetic variant on BP and related central haemodynamic parameters in healthy adults has not been previously investigated and was examined in this study.METHODS: Brachial BP, central BP and pulse wave velocity (PWV, SphygmoCor XCEL) were measured in adults aged 18-65 years prescreened for MTHFR genotype. Riboflavin status was assessed using the erythrocyte glutathione reductase activation coefficient assay.RESULTS: Two hundred and forty-two adults with the MTHFR 677TT genotype and age-matched non-TT (CC/CT) genotype controls were identified from a total cohort of 2546 adults prescreened for MTHFR genotype. The TT genotype was found to be an independent determinant of hypertension (p = 0.010), along with low-riboflavin status (p = 0.002). Brachial systolic and diastolic BP were higher in TT versus non-TT adults by 5.5 ± 1.2 and 2.4 ± 0.9 mmHg, respectively (both p < 0.001). A stronger phenotype was observed in women, with an almost 10 mmHg difference in mean systolic BP in TT versus non-TT genotype groups: 134.9 (95% confidence interval [CI] 132.1-137.6) versus 125.2 (95% CI 122.3-128.0) mmHg; p < 0.001. In addition, PWV was faster in women with the TT genotype (p = 0.043).CONCLUSION: This study provides the first evidence that brachial and central BP are significantly higher in adults with the variant MTHFR 677TT genotype and that the BP phenotype is more pronounced in women.",

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author = "Martina Rooney and Hughes, {Catherine F} and Strain, {J J} and Michelle Clements and Helene McNulty and Mary Ward",

note = "Funding Information: This work was supported, in part, by Ulster University funding from the Vice Chancellors Research Fund, which funded PhD studentship for Martina Rooney, and the Northern Ireland Clinical Research Facility. None of these entities were involved in the design, implementation, analysis or interpretation of the data. Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association.",

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pages = "689--700",

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T1 - Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults

AU - Rooney, Martina

AU - Hughes, Catherine F

AU - Strain, J J

AU - Clements, Michelle

AU - McNulty, Helene

AU - Ward, Mary

N1 - Funding Information: This work was supported, in part, by Ulster University funding from the Vice Chancellors Research Fund, which funded PhD studentship for Martina Rooney, and the Northern Ireland Clinical Research Facility. None of these entities were involved in the design, implementation, analysis or interpretation of the data. Publisher Copyright: © 2022 The Authors. Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association.

PY - 2022/8/2

Y1 - 2022/8/2

N2 - BACKGROUND: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk of hypertension and cardiovascular disease. Riboflavin, the MTHFR cofactor, is an important modulator of blood pressure (BP) in adults homozygous for this polymorphism (TT genotype). The effect of this genetic variant on BP and related central haemodynamic parameters in healthy adults has not been previously investigated and was examined in this study.METHODS: Brachial BP, central BP and pulse wave velocity (PWV, SphygmoCor XCEL) were measured in adults aged 18-65 years prescreened for MTHFR genotype. Riboflavin status was assessed using the erythrocyte glutathione reductase activation coefficient assay.RESULTS: Two hundred and forty-two adults with the MTHFR 677TT genotype and age-matched non-TT (CC/CT) genotype controls were identified from a total cohort of 2546 adults prescreened for MTHFR genotype. The TT genotype was found to be an independent determinant of hypertension (p = 0.010), along with low-riboflavin status (p = 0.002). Brachial systolic and diastolic BP were higher in TT versus non-TT adults by 5.5 ± 1.2 and 2.4 ± 0.9 mmHg, respectively (both p < 0.001). A stronger phenotype was observed in women, with an almost 10 mmHg difference in mean systolic BP in TT versus non-TT genotype groups: 134.9 (95% confidence interval [CI] 132.1-137.6) versus 125.2 (95% CI 122.3-128.0) mmHg; p < 0.001. In addition, PWV was faster in women with the TT genotype (p = 0.043).CONCLUSION: This study provides the first evidence that brachial and central BP are significantly higher in adults with the variant MTHFR 677TT genotype and that the BP phenotype is more pronounced in women.

AB - BACKGROUND: The C677T polymorphism in the gene-encoding methylenetetrahydrofolate reductase (MTHFR) is associated with an increased risk of hypertension and cardiovascular disease. Riboflavin, the MTHFR cofactor, is an important modulator of blood pressure (BP) in adults homozygous for this polymorphism (TT genotype). The effect of this genetic variant on BP and related central haemodynamic parameters in healthy adults has not been previously investigated and was examined in this study.METHODS: Brachial BP, central BP and pulse wave velocity (PWV, SphygmoCor XCEL) were measured in adults aged 18-65 years prescreened for MTHFR genotype. Riboflavin status was assessed using the erythrocyte glutathione reductase activation coefficient assay.RESULTS: Two hundred and forty-two adults with the MTHFR 677TT genotype and age-matched non-TT (CC/CT) genotype controls were identified from a total cohort of 2546 adults prescreened for MTHFR genotype. The TT genotype was found to be an independent determinant of hypertension (p = 0.010), along with low-riboflavin status (p = 0.002). Brachial systolic and diastolic BP were higher in TT versus non-TT adults by 5.5 ± 1.2 and 2.4 ± 0.9 mmHg, respectively (both p < 0.001). A stronger phenotype was observed in women, with an almost 10 mmHg difference in mean systolic BP in TT versus non-TT genotype groups: 134.9 (95% confidence interval [CI] 132.1-137.6) versus 125.2 (95% CI 122.3-128.0) mmHg; p < 0.001. In addition, PWV was faster in women with the TT genotype (p = 0.043).CONCLUSION: This study provides the first evidence that brachial and central BP are significantly higher in adults with the variant MTHFR 677TT genotype and that the BP phenotype is more pronounced in women.

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KW - personalised nutrition

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KW - haemodynamics

KW - riboflavin

KW - Medicine (miscellaneous)

KW - Nutrition and Dietetics

KW - Hypertension/genetics

KW - Pulse Wave Analysis

KW - Humans

KW - Genotype

KW - Riboflavin/genetics

KW - Blood Pressure/genetics

KW - Methylenetetrahydrofolate Reductase (NADPH2)/genetics

KW - Female

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DO - 10.1111/jhn.13061

M3 - Article

C2 - 35821207

SN - 0952-3871

VL - 35

SP - 689

EP - 700

JO - Journal of Human Nutrition and Dietetics

JF - Journal of Human Nutrition and Dietetics

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ER -

Impact of the MTHFR C677T polymorphism on blood pressure and related central haemodynamic parameters in healthy adults

Abstract

Bibliographical note

Keywords

UN SDGs

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