TY - JOUR
T1 - Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases
AU - Tew, Xin Nee
AU - Xin Lau, Natalie Jia
AU - Chellappan, Dinesh Kumar
AU - Madheswaran, Thiagarajan
AU - Zeeshan, Farrukh
AU - Tambuwala, Murtaza M.
AU - Aljabali, Alaa A
AU - Balusamy, Sri Renukadevi
AU - Perumalsamy, Haribalan
AU - Gupta, Gaurav
AU - Oliver, Brian G.
AU - Hus, Alan
AU - Wark, Peter
AU - Reddy, Karosham
AU - Wadhwa, Ridhima
AU - Hansbro, Philip Michael
AU - Dua, Kamal
N1 - Funding Information: The authors would like to thank International Medical University (IMU), Malaysia for providing the financial support for the project. Also, thanks to the Hunter Medical Research Institute (HMRI), The University of Newcastle, NSW 2308, Australia and the Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia for providing necessary support. Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.
AB - Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.
KW - Asthma
KW - Berberine
KW - COPD
KW - Inflammatory diseases
KW - Lung cancer
KW - Pulmonary fibrosis
KW - Respiratory diseases
UR - http://www.scopus.com/inward/record.url?scp=85078137548&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S0009279719318587
U2 - 10.1016/j.cbi.2020.108947
DO - 10.1016/j.cbi.2020.108947
M3 - Article
C2 - 31968208
VL - 317
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
SN - 0009-2797
M1 - 108947
ER -
