Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

Xin Nee Tew; Natalie Jia Xin Lau; Dinesh Kumar Chellappan; Thiagarajan Madheswaran; Farrukh Zeeshan; Murtaza M. Tambuwala; Alaa A Aljabali; Sri Renukadevi Balusamy; Haribalan Perumalsamy; Gaurav Gupta; Brian G. Oliver; Alan Hus; Peter Wark; Karosham Reddy; Ridhima Wadhwa; Philip Michael Hansbro; Kamal Dua

doi:10.1016/j.cbi.2020.108947

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

Xin Nee Tew, Natalie Jia Xin Lau, Dinesh Kumar Chellappan, Thiagarajan Madheswaran, Farrukh Zeeshan, Murtaza M. Tambuwala, Alaa A Aljabali, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Gaurav Gupta, Brian G. Oliver, Alan Hus, Peter Wark, Karosham Reddy, Ridhima Wadhwa, Philip Michael Hansbro, Kamal Dua

School of Pharm. & Pharmaceut. Sc.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

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Abstract

Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.

Original language	English
Article number	108947
Number of pages	46
Journal	Chemico-Biological Interactions
Volume	317
Early online date	20 Jan 2020
DOIs	https://doi.org/10.1016/j.cbi.2020.108947
Publication status	Published (in print/issue) - 1 Feb 2020

Bibliographical note

Funding Information: The authors would like to thank International Medical University (IMU), Malaysia for providing the financial support for the project. Also, thanks to the Hunter Medical Research Institute (HMRI), The University of Newcastle, NSW 2308, Australia and the Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia for providing necessary support. Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Asthma
Berberine
COPD
Inflammatory diseases
Lung cancer
Pulmonary fibrosis
Respiratory diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cbi.2020.108947

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Tew, X. N., Xin Lau, N. J., Chellappan, D. K., Madheswaran, T., Zeeshan, F., Tambuwala, M. M., Aljabali, A. A., Balusamy, S. R., Perumalsamy, H., Gupta, G., Oliver, B. G., Hus, A., Wark, P., Reddy, K., Wadhwa, R., Hansbro, P. M., & Dua, K. (2020). Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases. Chemico-Biological Interactions, 317, Article 108947. Advance online publication. https://doi.org/10.1016/j.cbi.2020.108947

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title = "Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases",

abstract = "Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.",

keywords = "Asthma, Berberine, COPD, Inflammatory diseases, Lung cancer, Pulmonary fibrosis, Respiratory diseases",

author = "Tew, {Xin Nee} and {Xin Lau}, {Natalie Jia} and Chellappan, {Dinesh Kumar} and Thiagarajan Madheswaran and Farrukh Zeeshan and Tambuwala, {Murtaza M.} and Aljabali, {Alaa A} and Balusamy, {Sri Renukadevi} and Haribalan Perumalsamy and Gaurav Gupta and Oliver, {Brian G.} and Alan Hus and Peter Wark and Karosham Reddy and Ridhima Wadhwa and Hansbro, {Philip Michael} and Kamal Dua",

note = "Funding Information: The authors would like to thank International Medical University (IMU), Malaysia for providing the financial support for the project. Also, thanks to the Hunter Medical Research Institute (HMRI), The University of Newcastle, NSW 2308, Australia and the Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia for providing necessary support. Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.cbi.2020.108947",

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Tew, XN, Xin Lau, NJ, Chellappan, DK, Madheswaran, T, Zeeshan, F, Tambuwala, MM, Aljabali, AA, Balusamy, SR, Perumalsamy, H, Gupta, G, Oliver, BG, Hus, A, Wark, P, Reddy, K, Wadhwa, R, Hansbro, PM & Dua, K 2020, 'Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases', Chemico-Biological Interactions, vol. 317, 108947. https://doi.org/10.1016/j.cbi.2020.108947

TY - JOUR

T1 - Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

AU - Tew, Xin Nee

AU - Xin Lau, Natalie Jia

AU - Chellappan, Dinesh Kumar

AU - Madheswaran, Thiagarajan

AU - Zeeshan, Farrukh

AU - Tambuwala, Murtaza M.

AU - Aljabali, Alaa A

AU - Balusamy, Sri Renukadevi

AU - Perumalsamy, Haribalan

AU - Gupta, Gaurav

AU - Oliver, Brian G.

AU - Hus, Alan

AU - Wark, Peter

AU - Reddy, Karosham

AU - Wadhwa, Ridhima

AU - Hansbro, Philip Michael

AU - Dua, Kamal

N1 - Funding Information: The authors would like to thank International Medical University (IMU), Malaysia for providing the financial support for the project. Also, thanks to the Hunter Medical Research Institute (HMRI), The University of Newcastle, NSW 2308, Australia and the Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia for providing necessary support. Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.

AB - Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.

KW - Asthma

KW - Berberine

KW - COPD

KW - Inflammatory diseases

KW - Lung cancer

KW - Pulmonary fibrosis

KW - Respiratory diseases

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UR - https://www.sciencedirect.com/science/article/pii/S0009279719318587

U2 - 10.1016/j.cbi.2020.108947

DO - 10.1016/j.cbi.2020.108947

M3 - Article

C2 - 31968208

SN - 0009-2797

VL - 317

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

M1 - 108947

ER -

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases

Abstract

Bibliographical note

Keywords

UN SDGs

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